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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
Open accessAbstract
To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, m urine p rostate restricted A kt k inase activity was generated in t ransgenic mice (MPAKT mice). Akt expression led to p70 S6K activation, prostatic intraepithelial neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral prostate revealed similarities to human cancer and an angiogenic signature that included three angiogenin family members, one of which was found elevated in the plasma of men with prostate cancer. Thus, the MPAKT model may be useful in studying the role of Akt in prostate epithelial cell transformation and in the discovery of molecular markers relevant to human disease.
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Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., et al. (2000) · Genes & Development · doi:10.1101/gad.14.4.391 · Cited by 840
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Luo, J., Manning, B. D., & Cantley, L. C. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00248-4 · Cited by 1,290
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Lim, E.-K., Kim, T., Paik, S., Haam, S., Huh, Y.-M., & Lee, K. (2015) · Chemical Reviews · doi:10.1021/cr300213b · Cited by 1,233
Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G. V., Li, G., Roy-Burman, P., Nelson, P. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00215-0 · Cited by 1,109
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Salmena, L., Carracedo, A., & Pandolfi, P. P. (2008) · Cell · doi:10.1016/j.cell.2008.04.013 · Cited by 1,034
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Debnath, J., & Brugge, J. S. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1695 · Cited by 1,015
Metadata
- Authors
- Majumder, P. K., Yeh, J. J., George, D. J., Febbo, P. G., Kum, J., Xue, Q., Bikoff, R., Ma, H., Kantoff, P. W., Golub, T. R., Loda, M., & Sellers, W. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-06-10
- Volume
- 100
- Issue
- 13
- Pages
- 7841-7846
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2102103107
- Cited by
- 285
- References
- 1
- FWCI
- 16.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Majumder, P. K., Yeh, J. J., George, D. J., Febbo, P. G., Kum, J., Xue, Q., Bikoff, R., Ma, H., Kantoff, P. W., Golub, T. R., Loda, M., & Sellers, W. R. (2003). Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1232229100
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