Targeting the PI3K-Akt pathway in human cancer

The phosphoinositide 3-kinase pathway

Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works

Specific protection against breast cancers by cyclin D1 ablation

Yu, Q., Geng, Y., & Sicinski, P. (2001) · Nature · doi:10.1038/35082500 · Cited by 934 · see citing works

Senescence, apoptosis and therapy — cutting the lifelines of cancer

Schmitt, C. A. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1044 · Cited by 295 · see citing works

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Engelman, J. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2664 · Cited by 2,445 · see citing works

Ras, PI(3)K and mTOR signalling controls tumour cell growth

Shaw, R. J., & Cantley, L. C. (2006) · Nature · doi:10.1038/nature04869 · Cited by 2,019 · see citing works

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686 · see citing works

New approaches and procedures for cancer treatment: Current perspectives

Debela, D. T., Muzazu, S. G., Heraro, K. D., Ndalama, M. T., Mesele, B. W., Haile, D. C., Kitui, S. K., & Manyazewal, T. (2021) · SAGE Open Medicine · doi:10.1177/20503121211034366 · Cited by 1,597 · see citing works

The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works

Pten Regulates Neuronal Arborization and Social Interaction in Mice

Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works

Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

Samuels, Y., Diaz, L. A., Schmidt-Kittler, O., Cummins, J. M., DeLong, L., Cheong, I., Rago, C., Huso, D. L., Lengauer, C., Kinzler, K. W., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.014 · Cited by 915 · see citing works

Dysregulation of mTOR signaling in fragile X syndrome

Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557 · see citing works

ATP citrate lyase is an important component of cell growth and transformation

Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208773 · Cited by 537 · see citing works

Neuronal Intrinsic Mechanisms of Axon Regeneration

Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458 · see citing works

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Guo, D., Reinitz, F., Youssef, M., Hong, C., Nathanson, D., Akhavan, D., Kuga, D., Amzajerdi, A. N., Soto, H., Zhu, S., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0102 · Cited by 452 · see citing works

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

Astle, M. V., Hannan, K. M., Ng, P. Y., Lee, R. S., George, A. J., Hsu, A. K., Haupt, Y., Hannan, R. D., & Pearson, R. B. (2012) · Oncogene · doi:10.1038/onc.2011.394 · Cited by 295 · see citing works

Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer

Wolpin, B. M., Hezel, A. F., Abrams, T., Blaszkowsky, L. S., Meyerhardt, J. A., Chan, J. A., Enzinger, P. C., Allen, B., Clark, J. W., Ryan, D. P., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.9514 · Cited by 297 · see citing works

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative

Molinolo, A. A., Hewitt, S. M., Amornphimoltham, P., Keelawat, S., Rangdaeng, S., Meneses García, A., Raimondi, A. R., Jufe, R., Itoiz, M., Gao, Y., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1041 · Cited by 243 · see citing works

Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck

Amornphimoltham, P., Patel, V., Sodhi, A., Nikitakis, N. G., Sauk, J. J., Sausville, E. A., Molinolo, A. A., & Gutkind, J. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0921 · Cited by 238 · see citing works

Phosphatidylinositol 3-Kinase-dependent Modulation of Carnitine Palmitoyltransferase 1A Expression Regulates Lipid Metabolism during Hematopoietic Cell Growth

DeBerardinis, R. J., Lum, J. J., & Thompson, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608372200 · Cited by 221 · see citing works

EWS–ETS oncoproteins: The linchpins of Ewing tumors

Janknecht, R. (2005) · Gene · doi:10.1016/j.gene.2005.08.007 · Cited by 173 · see citing works

Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein

Palamarchuk, A., Efanov, A., Maximov, V., Aqeilan, R. I., Croce, C. M., & Pekarsky, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3469 · Cited by 151 · see citing works

Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production

Lu, Y., Azad, N., Wang, L., Iyer, A. K. V., Castranova, V., Jiang, B.-H., & Rojanasakul, Y. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0002oc · Cited by 138 · see citing works

The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse

Hursting, S. D., Nunez, N. P., Varticovski, L., & Vinson, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4237 · Cited by 110 · see citing works

Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells

Chen, M., Sharma, A., Lin, Y., Wu, Y., He, Q., Gu, Y., Xu, Z. P., Monteiro, M., & Gu, W. (2019) · BMC Cancer · doi:10.1186/s12885-019-5364-3 · Cited by 53 · see citing works

Phosphorylation of Akt at the C-terminal tail triggers Akt Activation

Liu, P., Wang, Z., & Wei, W. (2014) · Cell Cycle · doi:10.4161/cc.29584 · Cited by 49 · see citing works

Plant-based and animal-based low-carbohydrate diets and risk of hepatocellular carcinoma among US men and women

Liu, Y., Yang, W., VoPham, T., Ma, Y., Simon, T. G., Gao, X., Chan, A. T., Meyerhardt, J. A., Giovannucci, E. L., & Zhang, X. (2021) · Hepatology · doi:10.1002/hep.31251 · Cited by 40 · see citing works

PH domain-mediated autoinhibition and oncogenic activation of Akt

Bae, H., Viennet, T., Park, E., Chu, N., Salguero, A., Eck, M. J., Arthanari, H., & Cole, P. A. (2022) · eLife · doi:10.7554/elife.80148 · Cited by 31 · see citing works

Intake of high-fat diet stimulates the risk of ultraviolet radiation-induced skin tumors and malignant progression of papillomas to carcinoma in skh-1 hairless mice

Vaid, M., Singh, T., Prasad, R., & Katiyar, S. K. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.030 · Cited by 18 · see citing works