The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4
Open accessAbstract
Significance: Human embryonic stem cells (hESC) exposed to the growth factor bone morphogenic protein 4 (BMP4) in the absence of FGF2 have been used to study the development of placental trophoblasts, but the soundness of this model has been challenged by others who concluded that the directional differentiation was primarily toward the mesoderm lineage rather than trophoblast. Here we identify key culture conditions necessary for BMP4 to convert hESC to an epithelium that expresses a full range of trophoblast markers, demonstrates invasive properties, and releases large quantities of placental hormones, with no evidence for mesoderm formation.
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Cites
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., et al. (2008) · Nature · doi:10.1038/nature06894 · Cited by 1,389
Feeder-independent culture of human embryonic stem cells
Ludwig, T. E., Bergendahl, V., Levenstein, M. E., Yu, J., Probasco, M. D., & Thomson, J. A. (2006) · Nature Methods · doi:10.1038/nmeth902 · Cited by 681
Hemberger, M., Udayashankar, R., Tesar, P., Moore, H., & Burton, G. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq128 · Cited by 181
Cited by
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells
Warmflash, A., Sorre, B., Etoc, F., Siggia, E. D., & Brivanlou, A. H. (2014) · Nature Methods · doi:10.1038/nmeth.3016 · Cited by 885
Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
Immune mechanisms at the maternal-fetal interface: perspectives and challenges
PrabhuDas, M., Bonney, E., Caron, K., Dey, S., Erlebacher, A., Fazleabas, A., Fisher, S., Golos, T., Matzuk, M., McCune, J. M., et al. (2015) · Nature Immunology · doi:10.1038/ni.3131 · Cited by 615
Self-citationEstablishment of porcine and human expanded potential stem cells
Gao, X., Nowak-Imialek, M., Chen, X., Chen, D., Herrmann, D., Ruan, D., Chen, A. C. H., Eckersley-Maslin, M. A., Ahmad, S., Lee, Y. L., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0333-2 · Cited by 389
Metadata
- Authors
- Amita, M., Adachi, K., Alexenko, A. P., Sinha, S., Schust, D. J., Schulz, L. C., Roberts, R. M., & Ezashi, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-03-14
- Volume
- 110
- Issue
- 13
- Pages
- E1212-21
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084358775
- Cited by
- 273
- References
- 3
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Amita, M., Adachi, K., Alexenko, A. P., Sinha, S., Schust, D. J., Schulz, L. C., Roberts, R. M., & Ezashi, T. (2013). Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1303094110
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