The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms
Open accessAbstract
Significance: Nanoparticles are widely investigated for intracellular drug delivery and molecular imaging and should be designed to maximize cell uptake. Here the effects of particle geometry to maximize nanoparticle uptake by mammalian cells are evaluated. The findings show that uptake is governed by a combination of cell–particle adhesion, strain energy for membrane wrapping around the particle, and local particle concentration at the cell membrane, all of which are particle-shape–dependent. Under typical culture conditions, disc-shaped hydrophilic nanoparticles were internalized more efficiently than nanorods. Interestingly, larger nanodiscs and rods had higher uptake compared with the smallest particles tested. Mechanisms of uptake were also shape- and cell type-specific. These results provide important insights for rational design of nanocarriers to maximize intracellular delivery efficacy.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181
Harush-Frenkel, O., Rozentur, E., Benita, S., & Altschuler, Y. (2008) · Biomacromolecules · doi:10.1021/bm700535p · Cited by 405
Cited by
Role of nanoparticle size, shape and surface chemistry in oral drug delivery
Banerjee, A., Qi, J., Gogoi, R., Wong, J., & Mitragotri, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.051 · Cited by 773
The importance of nanoparticle shape in cancer drug delivery
Truong, N. P., Whittaker, M. R., Mak, C. W., & Davis, T. P. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.950564 · Cited by 594
Fabrication of Bioinspired Hydrogels: Challenges and Opportunities
Fan, H., & Gong, J. P. (2020) · Macromolecules · doi:10.1021/acs.macromol.0c00238 · Cited by 292
Magnetic Nanoparticles in Targeted Drug Delivery: a Review
kianfar, E. (2021) · Journal of Superconductivity and Novel Magnetism · doi:10.1007/s10948-021-05932-9 · Cited by 280
Agarwal, R., Jurney, P., Raythatha, M., Singh, V., Sreenivasan, S. V., Shi, L., & Roy, K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500441 · Cited by 169
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Metadata
- Authors
- Agarwal, R., Singh, V., Jurney, P., Shi, L., Sreenivasan, S. V., & Roy, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-10-07
- Volume
- 110
- Issue
- 43
- Pages
- 17247-17252
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2143439997
- Cited by
- 424
- References
- 4
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- green
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