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Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion
Open accessAbstract
Significance: Elevated expression of matrix metalloproteinase 1 (MMP1) is associated with a poor prognosis in a wide variety of advancing tumors, and thus MMPs have emerged as attractive targets for therapeutic strategies of metastatic tumors. However, clinical trials using MMP inhibitors in cancer therapy have proved to be disappointing. These studies support the contention that the use of broad-spectrum inhibitors of MMPs is insufficient for clinical benefit, as new compensatory pathways such as continuous production of exosomes derived from the tumor will be unaffected and will enhance the MMP produced by stromal cells. Therefore, a better understanding of the mechanisms used by tumor-derived exosomes in the induction of MMPs would permit the development of successful clinical strategies for novel MMP inhibitors.
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Cited by
Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682
Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003
Ectosomes and exosomes: shedding the confusion between extracellular vesicles
Cocucci, E., & Meldolesi, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.004 · Cited by 1,435
Syn, N., Wang, L., Sethi, G., Thiery, J.-P., & Goh, B.-C. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.04.006 · Cited by 478
Self-citationHyung, S., Ko, J., Heo, Y. J., Blum, S. M., Kim, S. T., Park, S. H., Park, J. O., Kang, W. K., Lim, H. Y., Klempner, S. J., et al. (2023) · Science Advances · doi:10.1126/sciadv.adk1098 · Cited by 47
Metadata
- Authors
- Atay, S., Banskota, S., Crow, J., Sethi, G., Rink, L., & Godwin, A. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-12-30
- Volume
- 111
- Issue
- 2
- Pages
- 711-716
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2146220993
- Cited by
- 168
- References
- 0
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Atay, S., Banskota, S., Crow, J., Sethi, G., Rink, L., & Godwin, A. K. (2014). Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1310501111
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