The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Three SNARE complexes cooperate to mediate membrane fusion
Open accessAbstract
Soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins of the syntaxin, SNAP-25, and VAMP families mediate intracellular membrane fusion through the formation of helical bundles that span opposing membranes. Soluble SNARE domains that lack their integral membrane anchors inhibit membrane fusion by forming nonfunctional complexes with endogenous SNARE proteins. In this study we investigate the dependence of membrane fusion on the concentration of a soluble SNARE coil domain derived from VAMP2. The increase in the inhibition of fusion observed with increasing concentration of inhibitor is best fit to a function that suggests three SNARE complexes cooperate to mediate fusion of a single vesicle. These three complexes likely contribute part of a protein and lipidic fusion pore.
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Cites
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Cited by
Membrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
Chapman, E. R. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm855 · Cited by 485
Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release
Kaeser, P. S., & Regehr, W. G. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170338 · Cited by 447
Transmembrane Segments of Syntaxin Line the Fusion Pore of Ca 2 +-Triggered Exocytosis
Han, X., Wang, C.-T., Bai, J., Chapman, E. R., & Jackson, M. B. (2004) · Science · doi:10.1126/science.1095801 · Cited by 346
Metadata
- Authors
- Hua, Y., & Scheller, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-06-26
- Volume
- 98
- Issue
- 14
- Pages
- 8065-8070
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975642381
- Cited by
- 206
- References
- 1
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Hua, Y., & Scheller, R. H. (2001). Three SNARE complexes cooperate to mediate membrane fusion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.131214798
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
