The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Transmembrane Segments of Syntaxin Line the Fusion Pore of Ca 2 +-Triggered Exocytosis
Abstract
The fusion pore of regulated exocytosis is a channel that connects and spans the vesicle and plasma membranes. The molecular composition of this important intermediate structure of exocytosis is unknown. Here, we found that mutations of some residues within the transmembrane segment of syntaxin (Syx), a plasma membrane protein essential for exocytosis, altered neurotransmitter flux through fusion pores and altered pore conductance. The residues that influenced fusion-pore flux lay along one face of an α-helical model. Thus, the fusion pore is formed at least in part by a circular arrangement of 5 to 8 Syx transmembrane segments in the plasma membrane.
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Cites
Ion Channels/Excitable Membranes
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SNAREpins: Minimal Machinery for Membrane Fusion
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Membrane Fusion and Exocytosis
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Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
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Release of secretory products during transient vesicle fusion
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Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.
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Self-citationMechanisms of Synaptic Vesicle Exocytosis
Lin, R. C., & Scheller, R. H. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.19 · Cited by 512
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
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Cited by
Membrane Hemifusion: Crossing a Chasm in Two Leaps
Chernomordik, L. V., & Kozlov, M. M. (2005) · Cell · doi:10.1016/j.cell.2005.10.015 · Cited by 376
Calcium signaling and exocytosis in adrenal chromaffin cells
García, A. G., García-De-Diego, A. M., Gandía, L., Borges, R., & García-Sancho, J. (2006) · Physiological Reviews · doi:10.1152/physrev.00039.2005 · Cited by 349
Liu, Y., Tewari, R., Ning, J., Blagborough, A. M., Garbom, S., Pei, J., Grishin, N. V., Steele, R. E., Sinden, R. E., Snell, W. J., et al. (2008) · Genes & Development · doi:10.1101/gad.1656508 · Cited by 320
Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion
Hui, E., Johnson, C. P., Yao, J., Dunning, F. M., & Chapman, E. R. (2009) · Cell · doi:10.1016/j.cell.2009.05.049 · Cited by 291
Self-citationOne SNARE complex is sufficient for membrane fusion
van den Bogaart, G., Holt, M. G., Bunt, G., Riedel, D., Wouters, F. S., & Jahn, R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1748 · Cited by 289
Metadata
- Authors
- Han, X., Wang, C.-T., Bai, J., Chapman, E. R., & Jackson, M. B.
- Venue
- Science
- Published
- 2004-04-09
- Volume
- 304
- Issue
- 5668
- Pages
- 289-292
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2154649008
- Cited by
- 346
- References
- 29
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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