Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
Open accessAbstract
Significance: Pertussis has reemerged as an important public health concern since current acellular pertussis vaccines (aP) replaced older whole-cell vaccines (wP). In this study, we show nonhuman primates vaccinated with aP were protected from severe symptoms but not infection and readily transmitted Bordetella pertussis to contacts. Vaccination with wP and previous infection induced a more rapid clearance compared with naïve and aP-vaccinated animals. While all groups possessed robust antibody responses, key differences in T-cell memory suggest that aP vaccination induces a suboptimal immune response that is unable to prevent infection. These data provide a plausible explanation for pertussis resurgence and suggest that attaining herd immunity will require the development of improved vaccination strategies that prevent B. pertussis colonization and transmission.
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The current pertussis vaccine prevents clinical disease but not infection, and probably not transmission.
“the current pertussis vaccine prevents clinical disease but not infection, and probably not transmission”
From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Warfel et al., 2014
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- Authors
- Warfel, J. M., Zimmerman, L. I., & Merkel, T. J.
- Affiliations
- Center for Biologics Evaluation and Research (US)
- ORCID
- Merkel, Tod J.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-11-25
- Volume
- 111
- Issue
- 2
- Pages
- 787-792
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3896208
- OpenAlex
- W2088199958
- Cited by
- 644
- References
- 59
- Citations by year
- 2026: 41 · 2025: 49 · 2024: 40 · 2023: 42 · 2022: 45 · 2021: 46 · 2020: 43 · 2019: 58 · 2018: 60 · 2017: 55 · 2016: 58 · 2015: 55 · 2014: 45 · 2013: 6 · 2012: 1
- FWCI
- 50.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P40OD010988, P40OD010431)
- National Institute of Allergy and Infectious Diseases (#Y1-AI-1727-01, Y01 AI001727, K08AI001727)
- National Center for Research Resources (R24RR016556, P40RR012317)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Diphtheria, Corynebacterium, and Tetanus
- Keywords
- pertussis, Bordetella pertussis, acellular pertussis vaccine, whole-cell pertussis vaccine, vaccine failure, bacterial colonization, transmission, pertussis resurgence, Th17 cells, Th1/Th2 immune response, T cell immunity, antibody response, secondary infection, baboons, nonhuman primate model
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Antibodies, Bacterial, Enzyme-Linked Immunosorbent Assay, Leukocytes, Mononuclear, Papio, United States, Whooping Cough, Colony Count, Microbial, Diphtheria-Tetanus-acellular Pertussis Vaccines
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