The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Visual account of protein investment in cellular functions
Open accessAbstract
Significance: Proteins, which constitute roughly half of the cell dry mass, are extremely diverse. By counting the protein copy number of each gene in the genome, we obtain the proteome—a comprehensive picture of a cell's biochemical machinery. The proteome reflects physiology, structure, metabolic capacities, and many other aspects of the cell's lifestyle. Here, we visualize quantitative proteome data using a graphical tool we call proteomaps, where proteins are shown as polygons whose sizes indicate the abundances. Proteins involved in similar cellular functions are arranged in adjacent locations, creating regions whose areas give insight into the relative investment in each functional class. Proteins or protein classes that dominate the proteomap indicate demanding cellular processes and promising targets for further research.
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Cites
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Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
Park, J. O., Rubin, S. A., Xu, Y.-F., Amador-Noguez, D., Fan, J., Shlomi, T., & Rabinowitz, J. D. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2077 · Cited by 453
Abiotic Stress in Crop Production
Kopecká, R., Kameniarová, M., Černý, M., Brzobohatý, B., & Novák, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076603 · Cited by 369
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Self-citationEssential metabolism for a minimal cell
Breuer, M., Earnest, E. E., Merryman, C., Wise, K. S., Sun, L., Lynott, M. R., Hutchison, C. A., Smith, H. O., Lapek, J. D., Gonzalez, D. J., et al. (2019) · eLife · doi:10.7554/elife.36842 · Cited by 190
“Omics scale visualization Voronoi treemaps (Figures 1, 3 and 17a) were constructed following (Liebermeister et al., 2014).”
Metadata
- Authors
- Liebermeister, W., Noor, E., Flamholz, A., Davidi, D., Bernhardt, J., & Milo, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-06-02
- Volume
- 111
- Issue
- 23
- Pages
- 8488-8493
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2018003897
- Cited by
- 416
- References
- 33
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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