The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo
Open accessAbstract
Significance: Although the vitamin D endocrine system has been well defined and the enzyme responsible for converting 25-hydroxyvitamin D to the final hormone, 1α,25-dihydroxyvitamin D 3 , is well understood, the enzyme responsible for the conversion of vitamin D to the blood form, 25-hydroxyvitamin D, has not been clearly identified. A case has been made for vitamin D 25-hydroxylase CYP2R1 as the responsible enzyme, but proof is lacking. We have produced a null mutant mouse lacking CYP2R1. With this model, we have shown that CYP2R1 is the major but not exclusive 25-hydroxylase and that there remains another significant enzyme responsible for this step in vitamin D activation that has yet to be identified.
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Blomberg Jensen, M., Nielsen, J. E., Jorgensen, A., Rajpert-De Meyts, E., Kristensen, D. M., Jorgensen, N., Skakkebaek, N. E., Juul, A., & Leffers, H. (2010) · Human Reproduction · doi:10.1093/humrep/deq024 · Cited by 354
Cooper, J. D., Smyth, D. J., Walker, N. M., Stevens, H., Burren, O. S., Wallace, C., Greissl, C., Ramos-Lopez, E., Hyppönen, E., Dunger, D. B., et al. (2011) · Diabetes · doi:10.2337/db10-1656 · Cited by 279
Cited by
Vitamin D metabolism, mechanism of action, and clinical applications
Bikle, D. D. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.12.016 · Cited by 1,933
The serum vitamin D metabolome: what we know and what is still to discover
Tuckey, R. C., Cheng, C. Y. S., & Slominski, A. T. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.09.003 · Cited by 245
Slominski, A. T., Brożyna, A. A., Zmijewski, M. A., Jóźwicki, W., Jetten, A. M., Mason, R. S., Tuckey, R. C., & Elmets, C. A. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.3 · Cited by 136
The role of vitamin D and vitamin D binding protein in chronic liver diseases
Pop, T. L., Sîrbe, C., Benţa, G., Mititelu, A., & Grama, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810705 · Cited by 105
Obesity Represses CYP2R1 , the Vitamin D 25‐Hydroxylase, in the Liver and Extrahepatic Tissues
Elkhwanky, M., Kummu, O., Piltonen, T. T., Laru, J., Morin‐Papunen, L., Mutikainen, M., Tavi, P., & Hakkola, J. (2020) · JBMR Plus · doi:10.1002/jbm4.10397 · Cited by 80
Metadata
- Authors
- Zhu, J. G., Ochalek, J. T., Kaufmann, M., Jones, G., & DeLuca, H. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-09-09
- Volume
- 110
- Issue
- 39
- Pages
- 15650-15655
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038469606
- Cited by
- 331
- References
- 3
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhu, J. G., Ochalek, J. T., Kaufmann, M., Jones, G., & DeLuca, H. F. (2013). CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1315006110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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