The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a
Open accessAbstract
Significance: Bacterial pathogens can use a syringe-like structure to inject virulence proteins (effectors) directly into host cells. The YopJ/HopZ superfamily of effectors found in animal and plant pathogens can modify host kinase proteins to suppress host immunity. In the model plant Arabidopsis , HopZ1a is recognized by the resistance protein ZAR1 to induce a robust immune response that blocks pathogen growth. Here, we show that the HopZ1a effector from the plant pathogen Pseudomonas syringae targets the Arabidopsis nonfunctional pseudokinase ZED1 and that ZED1 is required for recognition of HopZ1a by ZAR1. We hypothesize that HopZ1a targets kinases to promote pathogen virulence, and Arabidopsis ZED1 evolved as a decoy to trap HopZ1a in the ZAR1 complex for recognition by the plant immune system.
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Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
NLRs at the intersection of cell death and immunity
Ting, J. P.-Y., Willingham, S. B., & Bergstralh, D. T. (2008) · Nature Reviews Immunology · doi:10.1038/nri2296 · Cited by 371 · cited 2×
“Effector-triggered immunity (ETI) is activated by the recognition of pathogen-derived effector proteins by intracellular NB-LRR proteins that share structural features with animal nucleotide-binding domain, leucine-rich repeat containing (NLR) proteins (3).”
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Cited by
Plant–Pathogen Warfare under Changing Climate Conditions
Velásquez, A. C., Castroverde, C. D. M., & He, S. Y. (2018) · Current Biology · doi:10.1016/j.cub.2018.03.054 · Cited by 970
Evolutionary trajectory of pattern recognition receptors in plants
(2024) · doi:10.1038/s41467-023-44408-3 · Cited by 119
Metadata
- Authors
- Lewis, J. D., Lee, A. H.-Y., Hassan, J. A., Wan, J., Hurley, B., Jhingree, J. R., Wang, P. W., Lo, T., Youn, J.-Y., Guttman, D. S., & Desveaux, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-10-29
- Volume
- 110
- Issue
- 46
- Pages
- 18722-18727
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2150069840
- Cited by
- 210
- References
- 2
- FWCI
- 11.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a. https://app.cochat.ai/papers/10.1073/pnas.1315520110
- The paper
- Lewis, J. D., Lee, A. H.-Y., Hassan, J. A., Wan, J., Hurley, B., Jhingree, J. R., Wang, P. W., Lo, T., Youn, J.-Y., Guttman, D. S., & Desveaux, D. (2013). The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1315520110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
