The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin
Open accessAbstract
Significance: Inflammation promotes the initiation of various malignancies by inducing genetic and epigenetic changes. Here we show that bacterial infection-induced prostatitis results in microenvironmental changes that enhance the differentiation of prostate basal cells into luminal cells, a cellular process that rarely occurs under normal physiological conditions. Previously, we showed in a mouse model that disease initiation for prostate cancer with a basal cell origin requires and is limited by basal-to-luminal differentiation and that prostatic inflammation induced by bacterial infection accelerates disease initiation by enhancing basal-to-luminal differentiation. Collectively, our results show that inflammation-induced microenvironmental changes alter the prostate epithelial lineage differentiation program, and we propose this alteration as a distinct and complementary process through which inflammation promotes tumor initiation.
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Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G. V., Li, G., Roy-Burman, P., Nelson, P. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00215-0 · Cited by 1,109
Multipotent and unipotent progenitors contribute to prostate postnatal development
Ousset, M., Van Keymeulen, A., Bouvencourt, G., Sharma, N., Achouri, Y., Simons, B. D., & Blanpain, C. (2012) · Nature Cell Biology · doi:10.1038/ncb2600 · Cited by 221
Valdez, J. M., Zhang, L., Su, Q., Dakhova, O., Zhang, Y., Shahi, P., Spencer, D. M., Creighton, C. J., Ittmann, M. M., & Xin, L. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.07.003 · Cited by 86
Self-citation
Cited by
Lineage plasticity in cancer: a shared pathway of therapeutic resistance
Quintanal-Villalonga, Á., Chan, J. M., Yu, H. A., Pe’er, D., Sawyers, C. L., Sen, T., & Rudin, C. M. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0340-z · Cited by 572
The inflammatory microenvironment and microbiome in prostate cancer development
Sfanos, K. S., Yegnasubramanian, S., Nelson, W. G., & De Marzo, A. M. (2018) · Nature Reviews Urology · doi:10.1038/nrurol.2017.167 · Cited by 469
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra
Henry, G. H., Malewska, A., Joseph, D. B., Malladi, V. S., Lee, J., Torrealba, J., Mauck, R. J., Gahan, J. C., Raj, G. V., Roehrborn, C. G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.086 · Cited by 355
Munn, L. L. (2017) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1370 · Cited by 257
Fu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48
Metadata
- Authors
- Kwon, O.-J., Zhang, L., Ittmann, M. M., & Xin, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-12-23
- Volume
- 111
- Issue
- 5
- Pages
- E592-600
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1981802929
- Cited by
- 180
- References
- 3
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. https://app.cochat.ai/papers/10.1073/pnas.1318157111
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- Kwon, O.-J., Zhang, L., Ittmann, M. M., & Xin, L. (2014). Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1318157111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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