The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra
Open accessAbstract
A comprehensive cellular anatomy of normal human prostate is essential for solving the cellular origins of benign prostatic hyperplasia and prostate cancer. The tools used to analyze the contribution of individual cell types are not robust. We provide a cellular atlas of the young adult human prostate and prostatic urethra using an iterative process of single-cell RNA sequencing (scRNA-seq) and flow cytometry on ∼98,000 cells taken from different anatomical regions. Immunohistochemistry with newly derived cell type-specific markers revealed the distribution of each epithelial and stromal cell type on whole mounts, revising our understanding of zonal anatomy. Based on discovered cell surface markers, flow cytometry antibody panels were designed to improve the purification of each cell type, with each gate confirmed by scRNA-seq. The molecular classification, anatomical distribution, and purification tools for each cell type in the human prostate create a powerful resource for experimental design in human prostate disease.
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Cited by
HCA Lung Biological Network, Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0868-6 · Cited by 2,501
A single–cell type transcriptomics map of human tissues
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Regenerative potential of prostate luminal cells revealed by single-cell analysis
Karthaus, W. R., Hofree, M., Choi, D., Linton, E. L., Turkekul, M., Bejnood, A., Carver, B., Gopalan, A., Abida, W., Laudone, V., et al. (2020) · Science · doi:10.1126/science.aay0267 · Cited by 283
Biological determinants of PSMA expression, regulation and heterogeneity in prostate cancer
Bakht, M. K., & Beltran, H. (2025) · Nature Reviews Urology · doi:10.1038/s41585-024-00900-z · Cited by 158
Stress relief: emerging methods to mitigate dissociation-induced artefacts
Machado, L., Relaix, F., & Mourikis, P. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.05.004 · Cited by 70
Metadata
- Authors
- Henry, G. H., Malewska, A., Joseph, D. B., Malladi, V. S., Lee, J., Torrealba, J., Mauck, R. J., Gahan, J. C., Raj, G. V., Roehrborn, C. G., Hon, G. C., MacConmara, M. P., Reese, J. C., Hutchinson, R. C., Vezina, C. M., & Strand, D. W.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 25
- Issue
- 12
- Pages
- 3530-3542.e5
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2950114058
- Cited by
- 355
- References
- 58
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- gold
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- Henry, G. H., Malewska, A., Joseph, D. B., Malladi, V. S., Lee, J., Torrealba, J., Mauck, R. J., Gahan, J. C., Raj, G. V., Roehrborn, C. G., Hon, G. C., MacConmara, M. P., Reese, J. C., Hutchinson, R. C., Vezina, C. M., & Strand, D. W. (2018). A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra. Cell Reports. https://doi.org/10.1016/j.celrep.2018.11.086
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
