The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Inosine induces axonal rewiring and improves behavioral outcome after stroke
Open accessAbstract
Cerebral infarct (stroke) often causes devastating and irreversible losses of function, in part because of the brain's limited capacity for anatomical reorganization. The purine nucleoside inosine has previously been shown to induce neurons to express a set of growth-associated proteins and to extend axons in culture and in vivo . We show here that in adult rats with unilateral cortical infarcts, inosine stimulated neurons on the undamaged side of the brain to extend new projections to denervated areas of the midbrain and spinal cord. This growth was paralleled by improved performance on several behavioral measures.
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Cites
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Cited by
Harnessing neuroplasticity for clinical applications
Cramer, S. C., Sur, M., Dobkin, B. H., O'Brien, C., Sanger, T. D., Trojanowski, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., et al. (2011) · Brain · doi:10.1093/brain/awr039 · Cited by 1,259
Self-citationCharbonneau, M. R., O’Donnell, D., Blanton, L. V., Totten, S. M., Davis, J. C. C., Barratt, M. J., Cheng, J., Guruge, J., Talcott, M., Bain, J. R., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.024 · Cited by 606
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Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain
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A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke
Overman, J. J., Clarkson, A. N., Wanner, I. B., Overman, W. T., Eckstein, I., Maguire, J. L., Dinov, I. D., Toga, A. W., & Carmichael, S. T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204386109 · Cited by 245
Metadata
- Authors
- Chen, P., Goldberg, D. E., Kolb, B., Lanser, M., & Benowitz, L. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-06-25
- Volume
- 99
- Issue
- 13
- Pages
- 9031-9036
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2115659532
- Cited by
- 263
- References
- 46
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, P., Goldberg, D. E., Kolb, B., Lanser, M., & Benowitz, L. I. (2002). Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.132076299
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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