The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
RETRACTED: Regulation of cell proliferation and migration by p62 through stabilization of Twist1
Open accessAbstract
The selective autophagy substrate p62 serves as a molecular link between autophagy and cancer. Suppression of autophagy causes p62 accumulation and thereby contributes to tumorigenesis. Here we demonstrate that autophagy deficiency promotes cell proliferation and migration through p62-dependent stabilization of the oncogenic transcription factor Twist1. p62 binds to Twist1 and inhibits degradation of Twist1. In mice, p62 up-regulation promotes tumor cell growth and metastasis in a Twist1-dependent manner. Our findings demonstrate that Twist1 is a key downstream effector of p62 in regulation of cell proliferation and migration and suggest that targeting p62-mediated Twist1 stabilization is a promising therapeutic strategy for prevention and treatment of cancer.
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Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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“The multidomain protein p62/A170/SQSTM1 (hereafter referred to as “p62”) has been shown to be both a selective autophagy substrate and an autophagy adaptor protein that acts as a link between ubiquitination and autophagy (5, 6).”
BackgroundGuidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
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Self-citationThe Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis
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Cited by
Mechanism and medical implications of mammalian autophagy
Dikic, I., & Elazar, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0003-4 · Cited by 2,771
Dual role of autophagy in hallmarks of cancer
Singh, S. S., Vats, S., Chia, A. Y.-Q., Tan, T. Z., Deng, S., Ong, M. S., Arfuso, F., Yap, C. T., Goh, B. C., Sethi, G., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0046-6 · Cited by 542
LC3-Associated Phagocytosis and Inflammation
Heckmann, B. L., Boada-Romero, E., Cunha, L. D., Magne, J., & Green, D. R. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.08.012 · Cited by 276
Cellular and metabolic functions for autophagy in cancer cells
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Metadata
- Authors
- Qiang, L., Zhao, B., Ming, M., Wang, N., He, T.-C., Hwang, S., Thorburn, A., & He, Y.-Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-06-09
- Volume
- 111
- Issue
- 25
- Pages
- 9241-9246
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2021196087
- Cited by
- 215
- References
- 7
- FWCI
- 15.95
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
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- Qiang, L., Zhao, B., Ming, M., Wang, N., He, T.-C., Hwang, S., Thorburn, A., & He, Y.-Y. (2014). RETRACTED: Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1322913111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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