The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis
Open accessAbstract
The balance between cell death and survival, two critical aspects of oncogenic transformation, determines the outcome of tumorigenesis. Nuclear factor-kappaB (NF-kappaB) is a critical regulator of survival; it is induced by the oncogene Ras and, when inhibited, accounts for the cell death response of Ras-transformed cells. Here, we show that the signaling adaptor p62 is induced by Ras, its levels are increased in human tumors, and it is required for Ras-induced survival and transformation. p62-/- mice are resistant to Ras-induced lung adenocarcinomas. p62 is necessary for Ras to trigger IkappaB kinase (IKK) through the polyubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), and its deficiency produces increased reactive oxygen species (ROS) levels, which account for the enhanced cell death and reduced tumorigenicity of Ras in the absence of p62.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ALS-associated mutations in TBK1, OPTN, SQSTM1, and VCP all affect autophagy as well as microglial function and innate immunity.
“ALS-associated mutations in TBK1, OPTN, SQSTM1, and VCP all affect autophagy as well as microglial function and innate immunity [192,205,206,441–443].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [442]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
ras oncogenes in human cancer: a review.
Bos, J. L. (1989) · PubMed · Cited by 5,061 · see citing works
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · see citing works
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519 · see citing works
Targeting RAS signalling pathways in cancer therapy
Downward, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc969 · Cited by 3,262 · see citing works
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433 · see citing works
RAS oncogenes: the first 30 years
Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902 · see citing works
Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792 · see citing works
Ubiquitin signalling in the NF-κB pathway
Chen, Z. J. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-758 · Cited by 1,184 · see citing works
Maeda, S., Kamata, H., Luo, J., Leffert, H. L., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2005.04.014 · Cited by 1,165 · see citing works
Ea, C.-K., Deng, L., Xia, Z.-P., Pineda, G., & Chen, Z. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.026 · Cited by 998 · see citing works
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
Luo, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26322 · Cited by 879 · see citing works
IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain
Sakurai, H., Chiba, H., Miyoshi, H., Sugita, T., & Toriumi, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30353 · Cited by 827 · see citing works
Tuveson, D. A., Shaw, A. T., Willis, N. A., Silver, D. P., Jackson, E. L., Chang, S., Mercer, K. L., Grochow, R., Hock, H., Crowley, D., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00085-6 · Cited by 798 · see citing works
Madrid, L. V., Mayo, M. W., Reuther, J. Y., & Baldwin, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101103200 · Cited by 777 · see citing works
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G. (2001) · Nature · doi:10.1038/35104560 · Cited by 732 · see citing works
Inhibition of JNK activation through NF-κB target genes
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721 · see citing works
Chang, L., Kamata, H., Solinas, G., Luo, J.-L., Maeda, S., Venuprasad, K., Liu, Y.-C., & Karin, M. (2006) · Cell · doi:10.1016/j.cell.2006.01.021 · Cited by 706 · see citing works
Pham, C. G., Bubici, C., Zazzeroni, F., Papa, S., Jones, J., Alvarez, K., Jayawardena, S., De Smaele, E., Cong, R., Beaumont, C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.017 · Cited by 663 · see citing works
Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice
Gupta, S., Ramjaun, A. R., Haiko, P., Wang, Y., Warne, P. H., Nicke, B., Nye, E. L., Stamp, G., Alitalo, K. K., & Downward, J. (2007) · Cell · doi:10.1016/j.cell.2007.03.051 · Cited by 589 · see citing works
Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88
Rakoff-Nahoum, S., & Medzhitov, R. M. (2007) · Science · doi:10.1126/science.1140488 · Cited by 584 · see citing works
Fisher, G. H., Wellen, S. L., Klimstra, D., Lenczowski, J. M., Tichelaar, J. W., Lizak, M. J., Whitsett, J. A., Koretsky, A., & Varmus, H. E. (2001) · Genes & Development · doi:10.1101/gad.947701 · Cited by 582 · see citing works
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context
Guerra, C. E., Mijimolle, N., Dhawahir, A., Dubus, P. R., Barradas, M., Serrano, M., Campuzano, V., & Barbacid, M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00191-0 · Cited by 566 · see citing works
Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras
Mayo, M. W., Wang, C.-Y., Cogswell, P. C., Rogers-Graham, K., Lowe, S. W., Der, C. J., & Baldwin, A. S. (1997) · Science · doi:10.1126/science.278.5344.1812 · Cited by 532 · see citing works
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
Zhou, H., Wertz, I. E., O’Rourke, K. M., Ultsch, M. H., Seshagiri, S., Eby, M. T., Xiao, W., & Dixit, V. M. (2003) · Nature · doi:10.1038/nature02273 · Cited by 527 · see citing works
The atypical PKC‐interacting protein p62 channels NF‐κB activation by the IL‐1–TRAF6 pathway
Sanz, L., Diaz‐Meco, M. T., Nakano, H., & Moscat, J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.7.1576 · Cited by 436 · see citing works
Self-citationRequirement for Caspase-8 in NF-κB Activation by Antigen Receptor
Su, H. C., Bidère, N., Zheng, L., Cubre, A., Sakai, K., Dale, J. K., Salmena, L., Hakem, R., Straus, S. E., & Lenardo, M. J. (2005) · Science · doi:10.1126/science.1104765 · Cited by 427 · see citing works
The interaction of p62 with RIP links the atypical PKCs to NF‐κB activation
Sanz, L., Sánchez‐Gómez, P., Lallena, M., Díaz-Meco, M. T., & Moscat, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3044 · Cited by 410 · see citing works
Self-citationp38α MAP Kinase as a Sensor of Reactive Oxygen Species in Tumorigenesis
Dolado, I., Swat, A., Ajenjo, N., Vita, G. D., Cuadrado, A., & Nebreda, Á. R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.013 · Cited by 404 · see citing works
Finco, T. S., Westwick, J. K., Norris, J. L., Beg, A. A., Der, C. J., & Baldwin, A. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24113 · Cited by 375 · see citing works
Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway
Leitges, M., Sanz, L., Martı́n, P., Durán, Á., Braun, U., García, J. F., Camacho, F., Díaz-Meco, M. T., Rennert, P. D., & Moscat, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00361-6 · Cited by 371 · see citing works
Self-citationReactive oxygen species mediate crosstalk between NF-κB and JNK
Nakano, H., Nakajima, A., Sakon-Komazawa, S., Piao, J.-H., Xue, X., & Okumura, K. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401830 · Cited by 368 · see citing works
Activation of IκB Kinase β by Protein Kinase C Isoforms
Lallena, M.-J., Díaz-Meco, M. T., Bren, G. D., Payá, C. V., & Moscat, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2180 · Cited by 360 · see citing works
Self-citationDurán, A., Serrano, M., Leitges, M., Flores, J. M., Picard, S., Brown, J. P., Moscat, J., & Diaz-Meco, M. T. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00403-9 · Cited by 316 · see citing works
Self-citationVentura, J.-J., Cogswell, P., Flavell, R. A., Baldwin, A. S., & Davis, R. J. (2004) · Genes & Development · doi:10.1101/gad.1223004 · Cited by 303 · see citing works
Wooten, M. W., Geetha, T., Seibenhener, M. L., Babu, J. R., Díaz-Meco, M. T., & Moscat, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500237200 · Cited by 225 · see citing works
Self-citationEvidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.
Díaz-Meco, M. T., Lozano, J., Municio, M. M., Berra, E., Frutos, S., Sanz, L., & Moscat, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31753-8 · Cited by 220 · see citing works
Self-citationThe atypical protein kinase Cs
Moscat, J., & Díaz-Meco, M. T. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd098 · Cited by 217 · see citing works
Self-citationCell Signaling and Function Organized by PB1 Domain Interactions
Moscat, J., Díaz-Meco, M. T., Albert, A., & Campuzano, S. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.08.002 · Cited by 195 · see citing works
Self-citationModelling cancer in human skin tissue
Khavari, P. A. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1838 · Cited by 145 · see citing works
Suppression of Ras-stimulated transformation by the JNK signal transduction pathwayPreprint
Kennedy, N. J., Sluss, H. K., Jones, S. N., Bar‐Sagi, D., Flavell, R. A., & Davis, R. J. (2003) · Genes & Development · doi:10.1101/gad.1062903 · Cited by 139 · see citing works
CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activationPreprint
Grabiner, B. C., Blonska, M., Lin, P.-C., You, Y., Wang, D., Sun, J., Darnay, B. G., Dong, C., & Lin, X. (2007) · Genes & Development · doi:10.1101/gad.1502507 · Cited by 120 · see citing works
Arsura, M., Mercurio, F., Oliver, A. L., Thorgeirsson, S. S., & Sonenshein, G. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5381-5391.2000 · Cited by 118 · see citing works
Barradas, M., Monjas, A., Díaz-Meco, M. T., Serrano, M., & Moscat, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6362 · Cited by 114 · see citing works
Self-citationAn antiapoptotic protein, c‐FLIPL, directly binds to MKK7 and inhibits the JNK pathway
Nakajima, A., Komazawa‐Sakon, S., Takekawa, M., Sasazuki, T., Yeh, W., Yagita∥, H., Okumura, K., & Nakano, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601423 · Cited by 94 · see citing works
Ras regulation of NF-KB and apoptosis
Mayo, M. W., Norris, J. L., & Baldwin, A. S. (2001) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(01)33046-x · Cited by 75 · see citing works
Caspase-8 and c-FLIPL Associate in Lipid Rafts with NF-κB Adaptors during T Cell Activation
Misra, R. S., Russell, J. Q., Koenig, A., Hinshaw-Makepeace, J. A., Wen, R., Wang, D., Huo, H., Littman, D. R., Ferch, U., Ruland, J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610610200 · Cited by 73 · see citing works
Genetic inactivation of Par4 results in hyperactivation of NF‐κB and impairment of JNK and p38
Garcı́a-Cao, I., Lafuente, M. J., Criado, L. M., Díaz-Meco, M. T., Serrano, M., & Moscat, J. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor769 · Cited by 61 · see citing works
Self-citationMartı́n, P., Díaz-Meco, M. T., & Moscat, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601250 · Cited by 58 · see citing works
Self-citationPromoters, Co-Carcinogens and Inhibitors of Pulmonary Carcinogenesis in Mice: An Overview
Malkinson, A. M. (1991) · Experimental Lung Research · doi:10.3109/01902149109064430 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154 · see citing works
Autophagy: cellular and molecular mechanisms
Glick, D. R., Barth, S., & Macleod, K. F. (2010) · The Journal of Pathology · doi:10.1002/path.2697 · Cited by 3,815 · see citing works
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679 · see citing works
Selective autophagy mediated by autophagic adapter proteins
Johansen, T., & Lamark, T. (2011) · Autophagy · doi:10.4161/auto.7.3.14487 · Cited by 1,730 · see citing works
Autophagy Suppresses Tumorigenesis through Elimination of p62
Mathew, R., Karp, C. M., Beaudoin, B., Vuong, N., Chen, G., Chen, H.-Y., Bray, K., Reddy, A., Bhanot, G. V., Gélinas, C., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.048 · Cited by 1,723 · see citing works
Deconvoluting the context-dependent role for autophagy in cancer
White, E. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3262 · Cited by 1,698 · see citing works
Jain, A., Lamark, T., Sjøttem, E., Bowitz Larsen, K., Atesoh Awuh, J., Øvervatn, A., McMahon, M., Hayes, J. D., & Johansen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118976 · Cited by 1,472 · see citing works
Autophagy modulation as a potential therapeutic target for diverse diseases
Rubinsztein, D. C., Codogno, P., & Levine, B. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3802 · Cited by 1,429 · see citing works
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Guo, J. Y., Chen, H.-Y., Mathew, R., Fan, J., Strohecker, A. M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemons, J. M. S., Karantza, V., et al. (2011) · Genes & Development · doi:10.1101/gad.2016311 · Cited by 1,323 · see citing works
The role for autophagy in cancer
White, E. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73941 · Cited by 1,332 · see citing works
The Role of Autophagy in Cancer: Therapeutic Implications
Yang, Z. J., Chee, C. E., Huang, S., & Sinicrope, F. A. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0047 · Cited by 1,217 · see citing works
NF-κB, an Active Player in Human Cancers
Xia, Y., Shen, S., & Verma, I. M. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0112 · Cited by 1,213 · see citing works
Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.003 · Cited by 1,205 · see citing works
Autophagy in malignant transformation and cancer progression
Galluzzi, L., Pietrocola, F., Bravo‐San Pedro, J. M., Amaravadi, R. K., Baehrecke, E. H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D. A., Karantza, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490784 · Cited by 1,182 · see citing works
p62 at the crossroads of autophagy, apoptosis, and cancer
Moscat, J., & Diaz-Meco, M. T. (2009) · Cell · doi:10.1016/j.cell.2009.05.023 · Cited by 1,073 · see citing works
Self-citationTargeting Autophagy in Cancer: Recent Advances and Future Directions
Amaravadi, R. K., Kimmelman, A. C., & Debnath, J. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0292 · Cited by 928 · see citing works
Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M., & Nukina, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.039 · Cited by 692 · see citing works
Autophagy, Metabolism, and Cancer
White, E., Mehnert, J. M., & Chan, C. S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0490 · Cited by 669 · see citing works
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Ando, J., Iwadate, M., Yamamoto, M. P., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201102031 · Cited by 602 · see citing works
Physiological significance of selective degradation of p62 by autophagy
Komatsu, M., & Ichimura, Y. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.017 · Cited by 516 · see citing works
Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy
Poillet-Perez, L., Despouy, G., Delage-Mourroux, R., & Boyer-Guittaut, M. (2015) · Redox Biology · doi:10.1016/j.redox.2014.12.003 · Cited by 503 · see citing works
Autophagy in the liver: functions in health and disease
Ueno, T., & Komatsu, M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.185 · Cited by 500 · see citing works
p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
Durán, Á., Amanchy, R., Linares, J. F., Joshi, J. P., Abu‐Baker, S., Porollo, A., Hansen, M., Moscat, J., & Díaz-Meco, M. T. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.038 · Cited by 502 · see citing works
Self-citationLing, J., Kang, Y., Zhao, R., Xia, Q., Lee, D.-F., Chang, Z., Li, J., Peng, B., Fleming, J. B., Wang, H., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.12.006 · Cited by 513 · see citing works
A Small Molecule Inhibitor of Inducible Heat Shock Protein 70
Leu, J. I.-J., Pimkina, J. S., Frank, A. K., Murphy, M. E., & George, D. L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.023 · Cited by 442 · see citing works
Functions of autophagy in normal and diseased liver
Czaja, M. J., Ding, W., Donohue, T. M., Friedman, S. L., Js, K., Komatsu, M., Lemasters, J. J., Lemoine, A., Lin, J. D., Ou, J. J., et al. (2013) · Autophagy · doi:10.4161/auto.25063 · Cited by 435 · see citing works
Autophagy in tumour immunity and therapy
Xia, H., Green, D. R., & Zou, W. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00344-2 · Cited by 411 · see citing works
Maycotte, P., & Thorburn, A. M. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.14627 · Cited by 394 · see citing works
Autophagy as a molecular target for cancer treatment
Kocatürk, N. M., Akkoç, Y., Kığ, C., Bayraktar, O., Gözüaçık, D., & Kutlu, Ö. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.04.011 · Cited by 388 · see citing works
Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life
Chun, Y., & Kim, J. (2018) · Cells · doi:10.3390/cells7120278 · Cited by 385 · see citing works
Puissant, A., Robert, G., Fenouille, N., Luciano, F., Cassuto, J., Raynaud, S., & Auberger, P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3537 · Cited by 375 · see citing works
Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms12030 · Cited by 364 · see citing works
Life, death, and autophagy in cancer: NF-κB turns up everywhere
Verzella, D., Pescatore, A., Capece, D., Vecchiotti, D., Ursini, M. V., Franzoso, G., Alesse, E., & Zazzeroni, F. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2399-y · Cited by 348 · see citing works
Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy
Mortezaee, K., Salehi, E., Mirtavoos‐Mahyari, H., Motevaseli, E., Najafi, M., Farhood, B., Rosengren, R. J., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28122 · Cited by 342 · see citing works
Role of autophagy in suppression of inflammation and cancer
White, E., Karp, C. M., Strohecker, A. M., Guo, Y., & Mathew, R. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.008 · Cited by 330 · see citing works
The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy
Lippai, M., & Lőw, P. (2014) · BioMed Research International · doi:10.1155/2014/832704 · Cited by 324 · see citing works
Autolysosomal β‐catenin degradation regulates Wnt‐autophagy‐p62 crosstalk
Petherick, K. J., Williams, A. C., Lane, J. D., Ordóñez‐Morán, P., Huelsken, J., Collard, T. J., Smartt, H. J. M., Batson, J., Malik, K. T. A., Paraskeva, C., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.123 · Cited by 318 · see citing works
Valencia, T., Kim, J. Y., Abu-Baker, S., Moscat-Pardos, J., Ahn, C. S., Reina-Campos, M., Duran, A., Castilla, E. A., Metallo, C. M., Diaz-Meco, M. T., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.004 · Cited by 304 · see citing works
Self-citationp62/SQSTM1/A170: Physiology and pathology
Komatsu, M., Kageyama, S., & Ichimura, Y. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.07.004 · Cited by 301 · see citing works
The multiple roles of autophagy in cancer
Rosenfeldt, M. T., & Ryan, K. M. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr031 · Cited by 302 · see citing works
Full-coverage regulations of autophagy by ROS: from induction to maturation
Zhou, J., Li, X., Liu, Y. J., Ji, F., Wu, Y., Shen, H., & Lu, G. (2021) · Autophagy · doi:10.1080/15548627.2021.1984656 · Cited by 300 · see citing works
The IKK complex contributes to the induction of autophagy
Criollo, A., Senovilla, L., Authier, H., Maiuri, M. C., Morselli, E., Vitale, I., Kepp, O., Tasdemir, E., Galluzzi, L., Shen, S., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.364 · Cited by 296 · see citing works
Metabolism shapes the tumor microenvironment
Reina‐Campos, M., Moscat, J., & Díaz-Meco, M. T. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.05.006 · Cited by 295 · see citing works
Self-citationChang, Y., Yan, W., He, X., Zhang, L., Li, C., Huang, H., Nace, G., Geller, D. A., Lin, J., & Tsung, A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.009 · Cited by 288 · see citing works
p62/SQSTM1 – steering the cell through health and disease
Sánchez‐Martín, P., & Komatsu, M. (2018) · Journal of Cell Science · doi:10.1242/jcs.222836 · Cited by 280 · see citing works
Baldwin, A. S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01095.x · Cited by 277 · see citing works
Chourasia, A. H., Boland, M. L., & Macleod, K. F. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0130-8 · Cited by 271 · see citing works
Regulation of autophagy by stress-responsive transcription factors
Pietrocola, F., Izzo, V., Niso‐Santano, M., Vacchelli, E., Galluzzi, L., Maiuri, M. C., & Kroemer, G. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.05.008 · Cited by 270 · see citing works
Autophagy: shaping the tumor microenvironment and therapeutic response
Maes, H., Rubio, N., Garg, A. D., & Agostinis, P. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.04.005 · Cited by 266 · see citing works
Pankiv, S., Lamark, T., Bruun, J., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.039925 · Cited by 266 · see citing works
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis
Pan, J.-A., Sun, Y., Jiang, Y.-P., Bott, A. J., Jaber, N. L., Dou, Z., Yang, B., Chen, J.-S., Catanzaro, J. M., Du, C., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.02.007 · Cited by 266 · see citing works
Self-citationCytoprotective roles for autophagy
Moreau, K., Luo, S., & Rubinsztein, D. C. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.002 · Cited by 260 · see citing works
Cellular and metabolic functions for autophagy in cancer cells
Kenific, C. M., & Debnath, J. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.09.001 · Cited by 261 · see citing works
K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells
Linares, J. F., Durán, Á., Yajima, T., Pasparakis, M., Moscat, J., & Díaz-Meco, M. T. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.020 · Cited by 256 · see citing works
Self-citationAutophagy regulation and its role in cancer
Lorin, S., Hamaï, A., Mehrpour, M., & Codogno, P. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.06.007 · Cited by 247 · see citing works
Selective degradation of p62 by autophagy
Ichimura, Y., & Komatsu, M. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0220-1 · Cited by 242 · see citing works
p62/ SQSTM 1: ‘Jack of all trades’ in health and cancer
Sánchez‐Martín, P., Saito, T., & Komatsu, M. (2018) · FEBS Journal · doi:10.1111/febs.14712 · Cited by 242 · see citing works
p62: a versatile multitasker takes on cancer
Moscat, J., & Díaz-Meco, M. T. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.02.008 · Cited by 239 · see citing works
Self-citationDurán, Á., Hernandez, E. D., Reina‐Campos, M., Castilla, E. A., Subramaniam, S., Raghunandan, S., Roberts, L. R., Kisseleva, T., Karin, M., Díaz-Meco, M. T., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.09.004 · Cited by 240 · see citing works
Self-citationTargeting autophagy during cancer therapy to improve clinical outcomes
Levy, J. M. M., & Thorburn, A. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.009 · Cited by 237 · see citing works
Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
Sung, B., Chung, H. Y., & Kim, N. D. (2016) · Journal of Cancer Prevention · doi:10.15430/jcp.2016.21.4.216 · Cited by 238 · see citing works
When autophagy meets cancer through p62/SQSTM1.
Puissant, A., Fenouille, N., & Auberger, P. (2012) · Europe PMC (PubMed Central) · Cited by 236 · see citing works
Autophagic Regulation of p62 is Critical for Cancer Therapy
Islam, M. A., Sooro, M. A., & Zhang, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051405 · Cited by 234 · see citing works
Chloroquine and hydroxychloroquine for cancer therapy
Manic, G., Obrist, F., Kroemer, G., Vitale, I., & Galluzzi, L. (2014) · Molecular & Cellular Oncology · doi:10.4161/mco.29911 · Cited by 223 · see citing works
Autophagy and cancer – issues we need to digest
Liu, E. Y., & Ryan, K. M. (2012) · Journal of Cell Science · doi:10.1242/jcs.093708 · Cited by 219 · see citing works
Lee, H., Shin, D., Yuk, J., Shi, G., Choi, D.-K., Lee, S. S., Huang, S. M., Kim, J., Kim, C. D., Lee, J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001954 · Cited by 220 · see citing works
RETRACTED: Regulation of cell proliferation and migration by p62 through stabilization of Twist1
Qiang, L., Zhao, B., Ming, M., Wang, N., He, T., Hwang, S., Thorburn, A. M., & He, Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322913111 · Cited by 215 · see citing works
RetractedAutophagy Modulation in Cancer: Current Knowledge on Action and Therapy
Marinković, M., Šprung, M., Buljubašić, M., & Novak, I. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8023821 · Cited by 213 · see citing works
Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis
Stępkowski, T. M., & Kruszewski, M. K. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.033 · Cited by 212 · see citing works
Selective Autophagy in Cancer Development and Therapy
Đikić, I., Johansen, T., & Kirkin, V. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4027 · Cited by 212 · see citing works
The Role of Autophagy in Cancer
Santana-Codina, N., Mancias, J. D., & Kimmelman, A. C. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-041816-122338 · Cited by 207 · see citing works
Oncogenic functions of the transcription factor Nrf2
Gañán‐Gómez, I., Wei, Y., Yang, H., Boyano-Adánez, M. C., & Garcia‐Manero, G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.041 · Cited by 200 · see citing works
Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
The role of autophagy in tumour development and cancer therapy
Rosenfeldt, M. T., & Ryan, K. M. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001306 · Cited by 197 · see citing works
Autophagy in cellular metabolism and cancer
Jiang, X., Overholtzer, M., & Thompson, C. B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73942 · Cited by 198 · see citing works
Inhibition of KRAS -Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit
Zhu, Z., Aref, A. R., Cohoon, T. J., Barbie, T. U., Imamura, Y., Yang, S., Moody, S. E., Shen, R. R., Schinzel, A. C., Thai, T. C., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0646 · Cited by 193 · see citing works
Requirement of the NF-κB Subunit p65/RelA for K-Ras–Induced Lung Tumorigenesis
Bassères, D. S., Ebbs, A., Levantini, E., & Baldwin, A. S. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4290 · Cited by 189 · see citing works
Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent
Parkhitko, A. A., Myachina, F., Morrison, T. A., Hindi, K. M., Auricchio, N., Karbowniczek, M., Wu, J. J., Finkel, T., Kwiatkowski, D. J., Yu, J. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104361108 · Cited by 189 · see citing works
Hu, Y., Jahangiri, A., DeLay, M., & Aghi, M. K. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1076 · Cited by 188 · see citing works
Expanding perspectives on the significance of mitophagy in cancer
Drake, L. E., Springer, M. Z., Poole, L. P., Kim, C., & Macleod, K. F. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.008 · Cited by 190 · see citing works
Inflammatory signaling cascades and autophagy in cancer
Monkkonen, T., & Debnath, J. (2017) · Autophagy · doi:10.1080/15548627.2017.1345412 · Cited by 188 · see citing works
Role of autophagy in cancer prevention
Chen, H.-Y., & White, E. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0387 · Cited by 190 · see citing works
The interplay between autophagy and ROS in tumorigenesis
Kongara, S., & Karantza, V. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00171 · Cited by 182 · see citing works
Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation
Liu, B., Fang, M., Hu, Y., Huang, B., Li, N., Chang, C., Huang, R., Xu, X., Yang, Z., Chen, Z., et al. (2013) · Autophagy · doi:10.4161/auto.27286 · Cited by 184 · see citing works
p62 at the Interface of Autophagy, Oxidative Stress Signaling, and Cancer
Nezis, I. P., & Stenmark, H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4394 · Cited by 176 · see citing works
Chang, C.-P., Su, Y., Hu, C.-W., & Lei, H.-Y. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.146 · Cited by 175 · see citing works
TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer
Starczynowski, D. T., Lockwood, W. W., Deléhouzée, S., Chari, R., Węgrzyn, J., Fuller, M. E., Tsao, M., Lam, S. C., Gazdar, A. F., Lam, W. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58818 · Cited by 173 · see citing works
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1
Sun, X. Y., Liu, Y., Huang, Z., Xu, W., Hu, W., Yi, L., Liu, Z., Chan, H., Zeng, J., Liu, X., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-021-00916-7 · Cited by 167 · see citing works
Autophagy-Regulating microRNAs and Cancer
Gözüaçık, D., Akkoç, Y., Öztürk, D. G., & Koçak, M. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00065 · Cited by 172 · see citing works
p62/ SQSTM1 and Selective Autophagy in Cardiometabolic Diseases
Jeong, S., Zhang, X., Rodríguez-Vélez, A., Evans, T. D., & Razani, B. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7649 · Cited by 167 · see citing works
Regulation of Akt signaling activation by ubiquitination
Yang, W.-L., Wu, C.-Y., Wu, J., & Lin, H.-K. (2010) · Cell Cycle · doi:10.4161/cc.9.3.10508 · Cited by 164 · see citing works
SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer
Li, L., Shen, C., Nakamura, E., Ando, K., Signoretti, S., Beroukhim, R., Cowley, G. S., Lizotte, P. H., Liberzon, E., Bair, S. M., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.025 · Cited by 162 · see citing works
Schmitz, K. J., Ademi, C., Bertram, S., Schmid, K. W., & Baba, H. A. (2016) · World Journal of Surgical Oncology · doi:10.1186/s12957-016-0946-x · Cited by 159 · see citing works
Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62
Pursiheimo, J.-P., Rantanen, K., Heikkinen, P., Johansen, T., & Jaakkola, P. (2009) · Oncogene · doi:10.1038/onc.2008.392 · Cited by 161 · see citing works
Kudo, Y., Sugimoto, M., Arias, E., Kasashima, H., Cordes, T., Linares, J., Duran, A., Nakanishi, Y., Nakanishi, N., L’Hermitte, A., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.018 · Cited by 126 · see citing works
Self-citationTakagawa, T., Kitani, A., Fuss, I., Levine, B., Brant, S. R., Peter, I., Tajima, M., Nakamura, S., & Strober, W. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan8162 · Cited by 145 · see citing works
TP53 in bone and soft tissue sarcomas
Thoenen, E. A., Curl, A., & Iwakuma, T. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.06.010 · Cited by 137 · see citing works
Role of p62/SQSTM1 in liver physiology and pathogenesis
Manley, S., Williams, J. A., & Ding, W.-X. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213489446 · Cited by 135 · see citing works
Digaleh, H., Kiaei, M., & Khodagholi, F. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1409-y · Cited by 137 · see citing works
The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context
Xing, F., Hu, Q., Qin, Y., Xu, J., Zhang, B., Yu, X., & Wang, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.862743 · Cited by 136 · see citing works
- Authors
- Duran, A., Linares, J. F., Galvez, A. S., Wikenheiser, K., Flores, J. M., Diaz-Meco, M. T., & Moscat, J.
- Affiliations
- University of Cincinnati (US)
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Moscat, Jorge
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 13
- Issue
- 4
- Pages
- 343-354
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1981912182
- Cited by
- 541
- References
- 51
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 13 · 2023: 18 · 2022: 30 · 2021: 35 · 2020: 41 · 2019: 39 · 2018: 41 · 2017: 51 · 2016: 41 · 2015: 38 · 2014: 41 · 2013: 45 · 2012: 29
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Memorial Sloan-Kettering Cancer Center
- Cincinnati Children's Hospital Medical Center
- University of Cincinnati
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- p62, NF-κB signaling, oncogenic Ras, carcinogenesis, cell survival, cell death, TRAF6, IκB kinase, polyubiquitination, reactive oxygen species, lung adenocarcinoma, oncogenic transformation
- MeSH terms
- Animals, Cell Survival, Cell Transformation, Neoplastic, DNA-Binding Proteins, Humans, Lung Neoplasms, Neoplasms, Transcription, Genetic, Signal Transduction, NF-kappa B, RNA-Binding Proteins, Reactive Oxygen Species, ras Proteins, Cell Line, Tumor, Adaptor Proteins, Signal Transducing, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
