The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Antibiotics induce redox-related physiological alterations as part of their lethality
Open accessAbstract
Significance: Substantial knowledge exists about how antibiotics interfere with core bacterial processes by binding to specific targets. Recently it has become appreciated that blocking these functions alters cellular redox state, and these perturbations may contribute to the lethality of antibiotics. In this work we explore whether antibiotic treatment of bacteria affects cellular oxidative stress and the role of such stress in antibiotic-mediated killing. We find that antibiotics dynamically alter cellular respiration and induce lethal levels of intracellular hydrogen peroxide. Antioxidants, including oxidative stress defense proteins, significantly reduce the killing by antibiotics, which is highly sensitive to the presence of molecular oxygen. These findings underscore the complex nature of antibiotic action and suggest practical approaches to enhancing our current antibiotic arsenal.
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Cites
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BackgroundMetabolite-enabled eradication of bacterial persisters by aminoglycosides
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Antibiotic efficacy is linked to bacterial cellular respiration
Lobritz, M. A., Belenky, P., Porter, C. B. M., Gutierrez, A., Yang, J. H., Schwarz, E. G., Dwyer, D. J., Khalil, A. S., & Collins, J. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509743112 · Cited by 773
Self-citationPost-stress bacterial cell death mediated by reactive oxygen species
Hong, Y., Zeng, J., Wang, X., Drlica, K., & Zhao, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901730116 · Cited by 513
Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria
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The impact of horizontal gene transfer on the adaptive ability of the human oral microbiome
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Metadata
- Authors
- Dwyer, D. J., Belenky, P. A., Yang, J. H., MacDonald, I. C., Martell, J. D., Takahashi, N., Chan, C. T. Y., Lobritz, M. A., Braff, D., Schwarz, E. G., Ye, J. D., Pati, M., Vercruysse, M., Ralifo, P. S., Allison, K. R., Khalil, A. S., Ting, A. Y., Walker, G. C., & Collins, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-05-06
- Volume
- 111
- Issue
- 20
- Pages
- E2100-9
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039045853
- Cited by
- 948
- References
- 12
- FWCI
- 25.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Dwyer, D. J., Belenky, P. A., Yang, J. H., MacDonald, I. C., Martell, J. D., Takahashi, N., Chan, C. T. Y., Lobritz, M. A., Braff, D., Schwarz, E. G., Ye, J. D., Pati, M., Vercruysse, M., Ralifo, P. S., Allison, K. R., Khalil, A. S., Ting, A. Y., Walker, G. C., & Collins, J. J. (2014). Antibiotics induce redox-related physiological alterations as part of their lethality. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1401876111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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