The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Antibiotic efficacy is linked to bacterial cellular respiration
Open accessAbstract
Significance: The global burden of antibiotic resistance has created a demand to better understand the basic mechanisms of existing antibiotics. Of significant interest is how antibiotics may perturb bacterial metabolism, and how bacterial metabolism may influence antibiotic activity. Here, we study the interaction of bacteriostatic and bactericidal antibiotics, the two major phenotypic drug classes. Interestingly, the two classes differentially perturb bacterial cellular respiration, with major consequences for their intrinsic activity both alone and in combination. Of note, bacteriostatic antibiotics decelerate cellular respiration, generating a metabolic state that is prohibitive to killing. Further, we show that the efficacy of bactericidal drugs can be improved by increasing basal respiration, and we identify a respiration-related drug target that potentiates the activity of bactericidal antibiotics.
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Cites
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.049 · Cited by 2,982
Self-citationA Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
Andries, K., Verhasselt, P., Guillemont, J., Göhlmann, H. W. H., Neefs, J.-M., Winkler, H., Van Gestel, J., Timmerman, P., Zhu, M., Lee, E., et al. (2005) · Science · doi:10.1126/science.1106753 · Cited by 2,191 · cited 1×
“The F1F0 ATPase is the target of bedaquiline, a novel antibiotic for the treatment of tuberculosis (50, 51).”
BackgroundLi, G.-W., Burkhardt, D., Gross, C., & Weissman, J. S. (2014) · Cell · doi:10.1016/j.cell.2014.02.033 · Cited by 1,251
Pankey, G. A., & Sabath, L. D. (2004) · Clinical Infectious Diseases · doi:10.1086/381972 · Cited by 1,201
Ribosome-targeting antibiotics and mechanisms of bacterial resistance
Wilson, D. N. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3155 · Cited by 1,054
Antibiotics induce redox-related physiological alterations as part of their lethality
Dwyer, D. J., Belenky, P. A., Yang, J. H., MacDonald, I. C., Martell, J. D., Takahashi, N., Chan, C. T. Y., Lobritz, M. A., Braff, D., Schwarz, E. G., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401876111 · Cited by 948
Self-citationCorrelation of Daptomycin Bactericidal Activity and Membrane Depolarization in Staphylococcus aureus
Silverman, J. A., Perlmutter, N. G., & Shapiro, H. M. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.8.2538-2544.2003 · Cited by 656
Cho, H., Uehara, T., & Bernhardt, T. G. (2014) · Cell · doi:10.1016/j.cell.2014.11.017 · Cited by 642
A theoretical study on the amount of ATP required for synthesis of microbial cell material
Stouthamer, A. H. (1973) · Antonie van Leeuwenhoek · doi:10.1007/bf02578899 · Cited by 588
Kohanski, M. A., Dwyer, D. J., Wierzbowski, J., Cottarel, G., & Collins, J. J. (2008) · Cell · doi:10.1016/j.cell.2008.09.038 · Cited by 574
Self-citation
Cited by
A Deep Learning Approach to Antibiotic Discovery
Stokes, J. M., Yang, K., Swanson, K., Jin, W., Cubillos-Ruiz, A., Donghia, N. M., MacNair, C. R., French, S., Carfrae, L. A., Bloom-Ackermann, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.021 · Cited by 2,463
Self-citationLi, H., Zhou, X., Huang, Y., Liao, B., Cheng, L., & Ren, B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.622534 · Cited by 284
Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria
Su, Y.-B., Peng, B., Li, H., Cheng, Z.-X., Zhang, T.-T., Zhu, J.-X., Li, D., Li, M.-Y., Ye, J.-Z., Du, C.-C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714645115 · Cited by 271
Martini, M. C., Zhang, T., Williams, J. T., Abramovitch, R. B., Weathers, P. J., & Shell, S. S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113191 · Cited by 65
Potential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli
Fang, Z., Lai, F., Cao, K., Zhang, Z., Cao, L., Liu, S., Duan, Y., Yin, X., Ge, R., He, Q.-Y., et al. (2022) · mSystems · doi:10.1128/msystems.00649-22 · Cited by 40
Metadata
- Authors
- Lobritz, M. A., Belenky, P., Porter, C. B. M., Gutierrez, A., Yang, J. H., Schwarz, E. G., Dwyer, D. J., Khalil, A. S., & Collins, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-22
- Volume
- 112
- Issue
- 27
- Pages
- 8173-8180
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1518907982
- Cited by
- 773
- References
- 49
- FWCI
- 32.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lobritz, M. A., Belenky, P., Porter, C. B. M., Gutierrez, A., Yang, J. H., Schwarz, E. G., Dwyer, D. J., Khalil, A. S., & Collins, J. J. (2015). Antibiotic efficacy is linked to bacterial cellular respiration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1509743112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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