The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides
Open accessAbstract
Significance: Mycobacteria include human pathogens that still kill millions annually. They are naturally resistant to commonly used antibiotics, presumably because the cell interior is well protected by the presence of the lipid-rich cell wall, which is thought to exist as a membrane, or the outer membrane. However, it was not known whether a sufficient number of lipid molecules existed to form a bilayer within the cell wall. We used a unique method that extracts only cell-wall lipids and showed that there are indeed enough lipids to cover the cell surface entirely as a bilayer. The analysis of inner, cell-membrane lipids also gave an unexpected insight, suggesting that the nature of the inner membrane might also contribute to generalized drug resistance.
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Self-citation
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Dulberger, C. L., Rubin, E. J., & Boutte, C. C. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0273-7 · Cited by 365
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Kieser, K. J., & Rubin, E. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3299 · Cited by 268
MmpL3 is the flippase for mycolic acids in mycobacteria
Xu, Z., Meshcheryakov, V. A., Poce, G., & Chng, S.-S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700062114 · Cited by 201
Strategies Used by Bacteria to Grow in Macrophages
Mitchell*, G., Chen*, C., & Portnoy, D. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0012-2015 · Cited by 137
Cell Walls and Membranes of Actinobacteria
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Metadata
- Authors
- Bansal-Mutalik, R., & Nikaido, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-03-17
- Volume
- 111
- Issue
- 13
- Pages
- 4958-4963
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965453055
- Cited by
- 257
- References
- 32
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bansal-Mutalik, R., & Nikaido, H. (2014). Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1403078111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
