The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host–pathogen interaction
Open accessAbstract
Approximately one third of the world's population is infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich cell wall containing a vast repertoire of antigens, providing a hydrophobic impermeable barrier against chemical drugs, thus representing an attractive target for vaccine and drug development. Apart from the mycolyl-arabinogalactan-peptidoglycan complex, mycobacteria possess several immunomodulatory constituents, notably lipomannan and lipoarabinomannan. The availability of whole-genome sequences of M. tuberculosis and related bacilli over the past decade has led to the identification and functional characterization of various enzymes and the potential drug targets involved in the biosynthesis of these glycoconjugates. Both lipomannan and lipoarabinomannan possess highly variable chemical structures, which interact with different receptors of the immune system during host-pathogen interactions, such as Toll-like receptors-2 and C-type lectins. Recently, the availability of mutants defective in the synthesis of these glycoconjugates in mycobacteria and the closely related bacterium, Corynebacterium glutamicum, has paved the way for host-pathogen interaction studies, as well as, providing attenuated strains of mycobacteria for the development of new vaccine candidates. This review provides a comprehensive account of the structure, biosynthesis and immunomodulatory properties of these important glycoconjugates.
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Cites
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Cited by
The mycobacterial cell envelope — a moving target
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Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol
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Spatially distinct and metabolically active membrane domain in mycobacteria
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Metadata
- Authors
- Mishra, A. K., Driessen, N. N., Appelmelk, B. J., & Besra, G. S.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11
- Volume
- 35
- Issue
- 6
- Pages
- 1126-1157
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W1867652495
- Cited by
- 295
- References
- 12
- FWCI
- 14.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mishra, A. K., Driessen, N. N., Appelmelk, B. J., & Besra, G. S. (2011). Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host–pathogen interaction. FEMS Microbiology Reviews. https://doi.org/10.1111/j.1574-6976.2011.00276.x
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