Prevention of influenza by targeting host receptors using engineered proteins.
Open accessAbstract
There is a need for new approaches for the control of influenza given the burden caused by annual seasonal outbreaks, the emergence of viruses with pandemic potential, and the development of resistance to current antiviral drugs. We show that multivalent biologics, engineered using carbohydrate-binding modules specific for sialic acid, mask the cell-surface receptor recognized by the influenza virus and protect mice from a lethal challenge with 2009 pandemic H1N1 influenza virus. The most promising biologic protects mice when given as a single 1-μg intranasal dose 7 d in advance of viral challenge. There also is sufficient virus replication to establish an immune response, potentially protecting the animal from future exposure to the virus. Furthermore, the biologics appear to stimulate inflammatory mediators, and this stimulation may contribute to their protective ability. Our results suggest that this host-targeted approach could provide a front-line prophylactic that has the potential to protect against any current and future influenza virus and possibly against other respiratory pathogens that use sialic acid as a receptor.
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Carbohydrate-binding molecules specific for sialic acid demonstrated protective in vivo efficacy against influenza virus.
“The use of carbohydrate-binding molecules specific for sialic acid demonstrated protective in vivo efficacy against influenza virus and therefore could provide similar protection against EHV-1 infection and other pathogens that recognize sialic acid receptors (Connaris et al., 2014).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Connaris et al., 2014
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- Authors
- Connaris, H., Govorkova, E. A., Ligertwood, Y., Dutia, B. M., Yang, L., Tauber, S., Taylor, M. A., Alias, N., Hagan, R., Nash, A. A., Webster, R. G., & Taylor, G. L.
- Affiliations
- University of St Andrews (GB)
- St. Jude Children's Research Hospital (US)
- Roslin Institute (GB)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-04-14
- Volume
- 111
- Issue
- 17
- Pages
- 6401-6406
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4035977
- OpenAlex
- W1981689500
- Cited by
- 43
- References
- 36
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 4
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council (MR/L012847/1)
- Biotechnology and Biological Sciences Research Council (BBS/E/D/20241866)
- National Institute of Allergy and Infectious Diseases (HHSN266200700005C)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- influenza prevention, host-directed antiviral therapy, sialic acid, carbohydrate-binding module, 2009 pandemic H1N1 influenza, sialic acid-binding lectins, inflammatory mediators, antiviral resistance
- MeSH terms
- Animals, Body Weight, Dogs, Humans, Influenza, Human, Lung, Orthomyxoviridae Infections, Receptors, Cell Surface, Receptors, Virus, Protein Engineering, Survival Analysis, Inflammation Mediators, Chemokines, N-Acetylneuraminic Acid, Mice, Influenza A Virus, H1N1 Subtype, Madin Darby Canine Kidney Cells
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