Mechanisms underlying the activation of G-protein–gated inwardly rectifying K + (GIRK) channels by the novel anxiolytic drug, ML297

Significance Many neurotransmitters dampen excitability in the heart and brain by activating G-protein–gated inwardly rectifying K + (GIRK) channels. The lack of selective pharmacological tools for GIRK channels has hindered investigations into their physiological and pathophysiological relevance…