Cited by 617Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchIon Transport and Channel Regulation

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

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Lüscher, Christian, Slesinger, Paul A.·2010·Nature Reviews Neuroscience

Abstract

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission. GIRK channel function and trafficking are highly dependent on the channel subunit composition. Pharmacological investigations of GIRK channels and studies in animal models suggest that GIRK activity has an important role in physiological responses, including pain perception and memory modulation. Moreover, abnormal GIRK function has been implicated in altering neuronal excitability and cell death, which may be important in the pathophysiology of diseases such as epilepsy, Down's syndrome, Parkinson's disease and drug addiction. GIRK channels may therefore prove to be a valuable new therapeutic target.

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  • Several types of K+ channels function as general gatekeepers of neuronal excitability in numerous experimental systems.

    “there is increasing evidence that several types of K+ channels function as general gatekeepers of neuronal excitability in numerous experimental systems79, 80”

    From Neurobiology of resilience (2012) · cites this paper as [79]

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Authors
Lüscher, C., & Slesinger, P. A.
Affiliations
  • University of Geneva (CH)
  • Salk Institute for Biological Studies (US)
Corresponding author
  • Lüscher, Christian
  • Slesinger, Paul A.
Venue
Nature Reviews Neuroscience
Published
2010-04-14
Volume
11
Issue
5
Pages
301-315
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2138098510
Cited by
617
References
184
Citations by year
2026: 32 · 2025: 35 · 2024: 29 · 2023: 43 · 2022: 40 · 2021: 39 · 2020: 41 · 2019: 36 · 2018: 42 · 2017: 46 · 2016: 38 · 2015: 42 · 2014: 50 · 2013: 41 · 2012: 33
FWCI
2.92
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • McKnight Endowment Fund for Neuroscience
  • National Institute on Drug Abuse (R01DA019022)
  • National Institute of Neurological Disorders and Stroke (R01NS037682, R01 NS37682)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
GIRK channels, G protein-coupled inwardly rectifying potassium channels, neuronal excitability, G protein-coupled receptors, channel subunit composition, epilepsy, Down syndrome, drug addiction, Parkinson's disease, pain perception, memory modulation, neuronal cell death, therapeutic target
MeSH terms
Animals, Brain, Brain Diseases, Models, Neurological, Neurons, Pain, G Protein-Coupled Inwardly-Rectifying Potassium Channels

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