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Cited by 169

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Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development

Open access
Sapkota, Darshan, Chintala, Hemabindu, Wu, Fuguo, Fliesler, Steven J., Hu, Zihua, Mu, Xiuqian·2014·Proceedings of the National Academy of Sciences

Abstract

Significance: We show that the onecut transcription factors, Onecut1 and Onecut2, redundantly regulate the formation of all four early-born retinal cell types, namely horizontal cells, ganglion cells, cones, and amacrine cells, and prevent precocious formation of the late retinal cell type, rods. Expression profiling suggests these two factors regulate a shared set of downstream genes to maintain competence for the early retinal cell types and to regulate generation of various subtypes of retinal ganglion cells. This study lays the foundation for further examination of how onecut factors regulate cell differentiation in the retina, as well as in the central nervous system in general.

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Metadata

Authors
Sapkota, D., Chintala, H., Wu, F., Fliesler, S. J., Hu, Z., & Mu, X.
Venue
Proceedings of the National Academy of Sciences
Published
2014-09-16
Volume
111
Issue
39
Pages
E4086-95
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2017350075
Cited by
169
References
1
FWCI
2.68
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. https://app.cochat.ai/papers/10.1073/pnas.1405354111
The paper
Sapkota, D., Chintala, H., Wu, F., Fliesler, S. J., Hu, Z., & Mu, X. (2014). Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1405354111

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