mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition

Limon, Jose J.; So, Lomon; Jellbauer, Stefan; Chiu, Honyin; Corado, Juana; Sykes, Stephen M.; Raffatellu, Manuela; Fruman, David A.

doi:10.1073/pnas.1407104111

mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition

Significance Rapamycin is an immunosuppressive drug that partially inhibits the cellular kinase mammalian target of rapamycin (mTOR). This study uncovers previously unidentified mechanisms of mTOR signaling in B cells. Antigen recognition and other signals activate mTOR, a central driver of lymph…