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Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion

Schwartz, Christian, Turqueti-Neves, Adriana, Hartmann, Susanne, Yu, Philipp, Nimmerjahn, Falk, Voehringer, David·2014·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1412663111
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Abstract

Significance: Gastrointestinal worms (helminths) infect more than 2 billion people, and vaccines are not yet available. Helminths elicit a type 2 immune response characterized by high serum IgE levels and increased numbers of IL-4– or IL-13–secreting effector cells including Th2 cells, eosinophils, basophils, and type 2 innate lymphoid cells. We determined the mechanism by which basophils contribute to protection against secondary infections with gastrointestinal helminths. Here we demonstrate that basophils are recruited into the small intestine of infected mice and orchestrate the local type 2 immune response in this tissue. Basophil-mediated protection required the presence of IgE and the expression of activating Fc receptors and IL-4/IL-13 in basophils. These findings could help the development of new vaccination strategies against helminths.

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Metadata

Authors
Schwartz, C., Turqueti-Neves, A., Hartmann, S., Yu, P., Nimmerjahn, F., & Voehringer, D.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2014-11-17
Volume
111
Issue
48
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1412663111
Cited by
86
References
1
Language
en

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