The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Contingency and entrenchment in protein evolution under purifying selection
Open accessAbstract
Significance: How large a role does history play in evolution? Do later events depend critically on specific earlier events, or do all events occur more or less independently? If a change occurs early in evolution, does it become easier or harder to revert the change as time proceeds? Here, we explore these ideas in the context of protein evolution, by simulating sequence evolution under purifying selection and then systematically permuting the order of amino acid substitutions. Our results suggest that the amino acid substitutions that occur in evolution are typically contingent on the presence of prior substitutions, and that substitutions that occur early in evolution become entrenched and difficult to modify as subsequent substitutions accrue.
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Cites
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MethodInfluentialBlount, Z. D., Borland, C. Z., & Lenski, R. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803151105 · Cited by 840
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Genome-wide analysis of a long-term evolution experiment with Drosophila
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Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein
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Cited by
Starr, T. N., Greaney, A. J., Hilton, S. K., Ellis, D., Crawford, K. H. D., Dingens, A. S., Navarro, M. J., Bowen, J. E., Tortorici, M. A., Walls, A. C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.012 · Cited by 1,956
Causes of molecular convergence and parallelism in protein evolution
Storz, J. F. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.11 · Cited by 316
The Causes and Consequences of Genetic Interactions (Epistasis)
Domingo, J., Baeza-Centurion, P., & Lehner, B. (2019) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083118-014857 · Cited by 242
Novelty and Innovation in the History of Life
Erwin, D. H. (2015) · Current Biology · doi:10.1016/j.cub.2015.08.019 · Cited by 211
Usmanova, D. R., Bogatyreva, N. S., Ariño Bernad, J., Eremina, A. A., Gorshkova, A. A., Kanevskiy, G. M., Lonishin, L. R., Meister, A. V., Yakupova, A. G., Kondrashov, F. A., et al. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty340 · Cited by 93
Metadata
- Authors
- Shah, P., McCandlish, D. M., & Plotkin, J. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-08
- Volume
- 112
- Issue
- 25
- Pages
- E3226-35
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1512750650
- Cited by
- 179
- References
- 11
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Shah, P., McCandlish, D. M., & Plotkin, J. B. (2015). Contingency and entrenchment in protein evolution under purifying selection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1412933112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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