The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin
Open accessAbstract
Significance: Evolution of malaria parasite drug resistance has thwarted efforts to control this deadly disease. Use of drug combinations has been proposed to slow that evolution. Artemisinin is a favorite drug in the global war on malaria and is frequently used in combination therapies. Here we show that using the whole plant ( Artemisia annua ) from which artemisinin is derived can overcome parasite resistance and is actually more resilient to evolution of parasite resistance; i.e., parasites take longer to evolve resistance, thus increasing the effective life span of the therapy.
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“Another reason for increasing the in planta artemisinin content is that dry leaf consumption of A. annua is showing efficacy in human trials (Daddy et al. 2017; Munyangi et al. 2019) and seems resilient against the evolution of artemisinin drug resistance as maybe shown in humans (Daddy et al. 2017) and in Plasmodium yoelii -infected mice (Elfawal et al. 2015).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Elfawal et al. 2015
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Shen, Q., Zhang, L., Liao, Z., Wang, S., Yan, T., Shi, P., Liu, M., Fu, X., Pan, Q., Wang, Y., et al. (2018) · Molecular Plant · doi:10.1016/j.molp.2018.03.015 · Cited by 315
GLANDULAR TRICHOME ‐ SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua
Chen, M., Yan, T., Shen, Q., Lu, X., Pan, Q., Huang, Y., Tang, Y., Fu, X., Liu, M., Jiang, W., et al. (2016) · New Phytologist · doi:10.1111/nph.14373 · Cited by 230
Traditional application and modern pharmacological research of Artemisia annua L.
Feng, X., Cao, S., Qiu, F., & Zhang, B. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107650 · Cited by 193
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Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics
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Self-citation
Metadata
- Authors
- Elfawal, M. A., Towler, M. J., Reich, N. G., Weathers, P. J., & Rich, S. M.
- Affiliations
- University of Massachusetts Amherst (US)
- Worcester Polytechnic Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-01-05
- Volume
- 112
- Issue
- 3
- Pages
- 821-826
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4311864
- OpenAlex
- W2088835649
- Cited by
- 124
- References
- 65
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 6 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 17 · 2015: 9
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Center for Clinical and Translational Sciences (na)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Keywords
- Artemisia annua, artemisinin, antimalarial drug resistance, Plasmodium yoelii, Plasmodium chabaudi, whole plant extract, malaria treatment, resistance evolution, secondary metabolites, plant defense, combination therapy, rodent malaria model
- MeSH terms
- Animals, Antimalarials, Drug Resistance, Artemisia annua, Artemisinins, Mice
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