Cited by 124Malaria Research and ControlPhytochemical compounds biological activitiesSesquiterpenes and Asteraceae Studies

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Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin

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Elfawal, Mostafa A., Towler, Melissa J., Reich, Nicholas G., Weathers, Pamela J., Rich, Stephen M.·2015·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1413127112PMC PMC4311864

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Abstract

Significance: Evolution of malaria parasite drug resistance has thwarted efforts to control this deadly disease. Use of drug combinations has been proposed to slow that evolution. Artemisinin is a favorite drug in the global war on malaria and is frequently used in combination therapies. Here we show that using the whole plant ( Artemisia annua ) from which artemisinin is derived can overcome parasite resistance and is actually more resilient to evolution of parasite resistance; i.e., parasites take longer to evolve resistance, thus increasing the effective life span of the therapy.

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10.1016/S0140-6736(05)67787-2 · DOI
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Authors: Elfawal, M. A., Towler, M. J., Reich, N. G., Weathers, P. J., & Rich, S. M.
Affiliations: University of Massachusetts Amherst (US)
Worcester Polytechnic Institute (US)
ORCID: Reich, Nicholas G.
Weathers, Pamela J.
Rich, Stephen M.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2015-01-05
Volume: 112
Issue: 3
Pages: 821-826
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1413127112
PMC: PMC4311864
OpenAlex: W2088835649
Cited by: 124
References: 65
Citations by year: 2026: 9 · 2025: 14 · 2024: 6 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 17 · 2015: 9
FWCI: 15.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Center for Clinical and Translational Sciences (na)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Keywords: Artemisia annua, artemisinin, antimalarial drug resistance, Plasmodium yoelii, Plasmodium chabaudi, whole plant extract, malaria treatment, resistance evolution, secondary metabolites, plant defense, combination therapy, rodent malaria model
MeSH terms: Animals, Antimalarials, Drug Resistance, Artemisia annua, Artemisinins, Mice

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Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin

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