Arabidopsis OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesis
Open accessAbstract
Significance: Carotenoids are indispensable to plants and humans. Despite significant achievements in carotenoid research, we still lack the fundamental knowledge of the regulatory mechanisms underlying carotenogenesis in plants. Phytoene synthase (PSY) and ORANGE (OR) are the two key proteins for carotenoid biosynthesis and accumulation in plastids. This study shows that OR family proteins interact directly with PSY and function as the major regulators of active PSY protein abundance in mediating carotenoid biosynthesis. The findings establish posttranscriptional regulation of PSY as a novel way to control carotenoid biosynthesis in plants and provide strategies for crop nutritional quality improvement.
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Overexpression of the Or gene increases carotenoid content by post-transcriptionally regulating PSY.
“Overexpression of Or gene has been shown to increase carotenoid content by post-transcriptionally regulating PSY (Zhou et al., 2015).”
From Integrated analysis of carotenoid metabolites and transcriptome identifies key genes controlling carotenoid compositions and content in sweetpotato tuberous roots (Ipomoea batatas L.) (2022) · cites this paper as Zhou et al., 2015
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Ren, Y., Deng, J., Huang, J., Wu, Z., Yi, L., Bi, Y., & Chen, F. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125736 · Cited by 155 · see citing works
Metabolic engineering of carotenoids in transgenic sweetpotato
Kang, L., Park, S.-C., Ji, C. Y., Kim, H. S., Lee, H.-S., & Kwak, S.-S. (2017) · Breeding Science · doi:10.1270/jsbbs.16118 · Cited by 59 · see citing works
Jia, R., Zhang, R., Gangurde, S. S., Tang, C., Jiang, B., Li, G., & Wang, Z. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.993682 · Cited by 20 · see citing works
- Authors
- Zhou, X., Welsch, R., Yang, Y., Álvarez, D., Riediger, M., Yuan, H., Fish, T., Liu, J., Thannhauser, T. W., & Li, L.
- Affiliations
- Agricultural Research Service (US)
- University of Freiburg (DE)
- Faculty of Biology II, University of Freiburg, D79104 Freiburg, Germany
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-02-09
- Volume
- 112
- Issue
- 11
- Pages
- 3558-3563
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4371912
- OpenAlex
- W2029957498
- Cited by
- 293
- References
- 0
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 22 · 2023: 27 · 2022: 32 · 2021: 40 · 2020: 33 · 2019: 23 · 2018: 24 · 2017: 22 · 2016: 16 · 2015: 10
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (4731/2-1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Keywords
- phytoene synthase, carotenoid biosynthesis, post-transcriptional regulation, Arabidopsis thaliana, protein-protein interaction, plastids, functional redundancy, carotenoid accumulation
- MeSH terms
- Carotenoids, Protein Binding, Mass Spectrometry, Structure-Activity Relationship, Arabidopsis, Plastids, Gene Expression Regulation, Plant, Arabidopsis Proteins, Immunoprecipitation, Geranylgeranyl-Diphosphate Geranylgeranyltransferase, Protein Multimerization, Gene Knockout Techniques
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