Using green alga Haematococcus pluvialis for astaxanthin and lipid co-production: Advances and outlook

Primary production of the biosphere: Integrating terrestrial and oceanic components

Field, C. B., Behrenfeld, M. J., Randerson, J. T., & Falkowski, P. (1998) · Science · doi:10.1126/science.281.5374.237 · Cited by 6,371 · see citing works

Microalgae for biodiesel production and other applications: A review

Mata, T. M., Martins, A. A., & Caetano, N. S. (2010) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2009.07.020 · Cited by 5,685 · see citing works

Omega-3 fatty acids EPA and DHA: Health benefits throughout life

Swanson, D., Block, R., & Mousa, S. A. (2012) · Advances in Nutrition · doi:10.3945/an.111.000893 · Cited by 1,575 · see citing works

THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS

Lichtenthaler, H. K. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.47 · Cited by 1,403 · see citing works

Astaxanthin: a review of its chemistry and applications

Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957188 · Cited by 1,287 · see citing works

Carotenoid Metabolism in Plants

Nisar, N., Li, L., Lu, S., Khin, N. C., & Pogson, B. J. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.007 · Cited by 1,261 · see citing works

A review on feedstocks, production processes, and yield for different generations of biodiesel

Singh), D. S. (., Sharma, D., Soni, S. L., Sharma, S., Sharma, P. K., & Jhalani, A. (2019) · Fuel · doi:10.1016/j.fuel.2019.116553 · Cited by 1,020 · see citing works

Astaxanthin-Producing Green Microalga Haematococcus pluvialis: From Single Cell to High Value Commercial Products

Shah, M. M. R., Liang, Y., Cheng, J. J., & Daroch, M. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00531 · Cited by 940 · see citing works

Bioremediation of heavy metals using microalgae: Recent advances and mechanisms

Leong, Y. K., & Chang, J.-S. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.122886 · Cited by 874 · see citing works

Effects of environmental factors and nutrient availability on the biochemical composition of algae for biofuels production: A Review

Juneja, A., Ceballos, R., & Murthy, G. (2013) · Energies · doi:10.3390/en6094607 · Cited by 835 · see citing works

Microalgae for High-Value Compounds and Biofuels Production: A Review with Focus on Cultivation under Stress Conditions

Markou, G., & Nerantzis, E. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.011 · Cited by 815 · see citing works

Microalgae-Based Wastewater Treatment for Nutrients Recovery: A Review

Li, K., Liu, Q., Fang, F., Luo, R., Lu, Q., Zhou, W., Huo, S., Cheng, P., Liu, J., Addy, M., et al. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121934 · Cited by 737 · see citing works

Carotenoids from microalgae: A review of recent developments

Gong, M., & Bassi, A. S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.10.005 · Cited by 727 · see citing works

CO2 Mitigation and Renewable Oil from Photosynthetic Microbes: A New Appraisal

Huntley, M. E., & Redalje, D. G. (2007) · Mitigation and Adaptation Strategies for Global Change · doi:10.1007/s11027-006-7304-1 · Cited by 633 · see citing works

Microalgae to Biofuels: ‘Promising’ Alternative and Renewable Energy, Review

Shuba, E. S., & Kifle, D. (2018) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2017.08.042 · Cited by 606 · see citing works

Development of Suitable Photobioreactor for Algae Production—A Review

Singh, R. N., & Sharma, S. (2012) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2012.01.026 · Cited by 605 · see citing works

Microalgae as a future food source

Torres-Tiji, Y., Fields, F. J., & Mayfield, S. P. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107536 · Cited by 559 · see citing works

Microalgae lipid and biomass for biofuel production: A comprehensive review on lipid enhancement strategies and their effects on fatty acid composition

Sajjadi, B., Chen, W.-Y., Raman, A. A. A., & Ibrahim, S. (2018) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2018.07.050 · Cited by 535 · see citing works

Potential utilization of bioproducts from microalgae for the quality enhancement of natural products

Tang, D. Y. Y., Khoo, K. S., Chew, K. W., Tao, Y., Ho, S., & Show, P. L. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.122997 · Cited by 393 · see citing works

Light emitting diodes (LEDs) applied to microalgal production

Schulze, P. S. C., Barreira, L. A., Pereira, H., Perales, J. A., & Varela, J. C. S. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.06.001 · Cited by 370 · see citing works

Manipulating environmental stresses and stress tolerance of microalgae for enhanced production of lipids and value-added products–a review

Chen, B., Wan, C., Mehmood, M. A., Chang, J.-S., Bai, F., & Zhao, X. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.05.170 · Cited by 346 · see citing works

Cell-wall disruption and lipid/astaxanthin extraction from microalgae: Chlorella and Haematococcus

Kim, D.-Y., Vijayan, D., Praveenkumar, R., Han, J., Lee, K., Park, J., Chang, W.-S., Lee, J., & Oh, Y. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.08.107 · Cited by 334 · see citing works

Chlorella zofingiensis as an Alternative Microalgal Producer of Astaxanthin: Biology and Industrial Potential

Liu, J., Sun, Z., Gerken, H. G., Liu, Z., Jiang, Y., & Chen, F. (2014) · Marine Drugs · doi:10.3390/md12063487 · Cited by 323 · see citing works

Recent advances in biorefinery of astaxanthin from Haematococcus pluvialis

Khoo, K. S., Lee, S. Y., Ooi, C. W., Fu, X., Miao, X., Ling, T. C., & Show, P. L. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121606 · Cited by 318 · see citing works

Recent advances in downstream processing of microalgae lipid recovery for biofuel production

Khoo, K. S., Chew, K. W., Yew, G. Y., Leong, W. H., Chai, Y. H., Show, P. L., & Chen, W.-H. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.122996 · Cited by 315 · see citing works

Metabolism of acyl‐lipids in <i>Chlamydomonas reinhardtii</i>

Li‐Beisson, Y., Beisson, F., & Riekhof, W. (2015) · The Plant Journal · doi:10.1111/tpj.12787 · Cited by 310 · see citing works

Trophic Conversion of an Obligate Photoautotrophic Organism Through Metabolic Engineering

Zaslavskaia, L. A., Lippmeier, J. C., Shih, C., Ehrhardt, D., Grossman, A. R., & Apt, K. E. (2001) · Science · doi:10.1126/science.160015 · Cited by 307 · see citing works

Lipid analysis in Haematococcus pluvialis to assess its potential use as a biodiesel feedstock

Damiani, M. C., Popovich, C. A., Constenla, D., & Leonardi, P. I. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2009.12.136 · Cited by 301 · see citing works

<i>Arabidopsis</i> OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesis

Zhou, X., Welsch, R., Yang, Y., Álvarez, D., Riediger, M., Yuan, H., Fish, T., Liu, J., Thannhauser, T. W., & Li, L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420831112 · Cited by 293 · see citing works

Astaxanthin in microalgae: pathways, functions and biotechnological implications

Han, D., Li, Y., & Hu, Q. (2013) · ALGAE · doi:10.4490/algae.2013.28.2.131 · Cited by 263 · see citing works

Advances in the Production of High-Value Products by Microalgae

Leu, S., & Boussiba, S. (2014) · Industrial Biotechnology · doi:10.1089/ind.2013.0039 · Cited by 253 · see citing works

Understanding precision nitrogen stress to optimize the growth and lipid content tradeoff in oleaginous green microalgae

Adams, C., Godfrey, V., Wahlen, B., Seefeldt, L., & Bugbee, B. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.12.143 · Cited by 242 · see citing works

Metabolic engineering of astaxanthin production in tobacco flowers

Mann, V., Harker, M., Pecker, I., & Hirschberg, J. (2000) · Nature Biotechnology · doi:10.1038/78515 · Cited by 239 · see citing works

Molecular mechanisms of the coordination between astaxanthin and fatty acid biosynthesis in Haematococcus pluvialis (Chlorophyceae)

Chen, G., Wang, B., Han, D., Sommerfeld, M. R., Lu, Y., Chen, F., & Hu, Q. (2014) · The Plant Journal · doi:10.1111/tpj.12713 · Cited by 234 · see citing works

Isolation and Characterization of the <i>Z-ISO</i> Gene Encoding a Missing Component of Carotenoid Biosynthesis in Plants

Chen, Y., Li, F., & Wurtzel, E. T. (2010) · Plant Physiology · doi:10.1104/pp.110.153916 · Cited by 226 · see citing works

Transformation of the Green Alga Haematococcus pluvialis with a Phytoene Desaturase for Accelerated Astaxanthin Biosynthesis

Steinbrenner, J., & Sandmann, G. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01461-06 · Cited by 226 · see citing works

Genetic engineering of microalgae for enhanced biorefinery capabilities

Fayyaz, M., Chew, K. W., Show, P. L., Ling, T. C., Ng, I.-S., & Chang, J.-S. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107554 · Cited by 225 · see citing works

Storage of starch and lipids in microalgae: Biosynthesis and manipulation by nutrients

Ran, W., Wang, H., Liu, Y., Qi, M., Xiang, Q., Yao, C., Zhang, Y., & Lan, X. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121894 · Cited by 224 · see citing works

Regulation of Two Carotenoid Biosynthesis Genes Coding for Phytoene Synthase and Carotenoid Hydroxylase during Stress-Induced Astaxanthin Formation in the Green Alga Haematococcus pluvialis

Steinbrenner, J., & Linden, H. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.2.810 · Cited by 221 · see citing works

On the relative efficiency of two‐ vs. one‐stage production of astaxanthin by the green alga Haematococcus pluvialis

Aflalo, C., Meshulam, Y., Zarka, A., & Boussiba, S. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21391 · Cited by 220 · see citing works

Analysis in Vitro of the Enzyme CRTISO Establishes a Poly-cis-Carotenoid Biosynthesis Pathway in Plants

Isaacson, T., Ohad, I., Beyer, P., & Hirschberg, J. (2004) · Plant Physiology · doi:10.1104/pp.104.052092 · Cited by 203 · see citing works

Microalgae under environmental stress as a source of antioxidants

Gauthier, M. R., Senhorinho, G. N. A., & Scott, J. A. (2020) · Algal Research · doi:10.1016/j.algal.2020.102104 · Cited by 202 · see citing works

Two-stage cultures for the production of Astaxanthin from Haematococcus pluvialis

Fábregas, J., Otero, A., Maseda, A., & Domı́nguez, A. (2001) · Journal of Biotechnology · doi:10.1016/s0168-1656(01)00289-9 · Cited by 200 · see citing works

Model development for the growth of microalgae: A review

Darvehei, P., Bahri, P. A., & Moheimani, N. R. (2018) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2018.08.027 · Cited by 199 · see citing works

Carotenoids from fungi and microalgae: A review on their recent production, extraction, and developments

Liu, C., Hu, B., Cheng, Y., Guo, Y., Yao, W., & Qian, H. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125398 · Cited by 196 · see citing works

Comparative analyses of lipidomes and transcriptomes reveal a concerted action of multiple defensive systems against photooxidative stress in Haematococcus pluvialis

Gwak, Y., Hwang, Y., Wang, B., Kim, M., Jeong, J., Lee, C., Hu, Q., Han, D., & Jin, E. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru206 · Cited by 194 · see citing works

Insights into upstream processing of microalgae: A review

Daneshvar, E., Ok, Y. S., Tavakoli, S., Sarkar, B., Shaheen, S. M., Hong, H., Luo, Y., Rinklebe, J., Song, H., & Bhatnagar, A. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.124870 · Cited by 188 · see citing works

Analysis and enhancement of astaxanthin accumulation in Haematococcus pluvialis

García, M. O. (2004) · Bioresource Technology · doi:10.1016/j.biortech.2004.04.006 · Cited by 185 · see citing works

Breaking new ground in the regulation of the early steps of plant isoprenoid biosynthesis

Rodrı́guez-Concepción, M., & Boronat, A. (2015) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2015.04.001 · Cited by 185 · see citing works

Health promoting functional lipids from microalgae pool: A review

Katiyar, R., & Arora, A. (2020) · Algal Research · doi:10.1016/j.algal.2020.101800 · Cited by 185 · see citing works

Research progress on extraction, biological activities and delivery systems of natural astaxanthin

Zhao, T., Yan, X., Sun, L., Yang, T., Hu, X., He, Z., Liu, F., & Liu, X. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.07.014 · Cited by 183 · see citing works

Growth and astaxanthin formation of Haematococcus pluvialis in heterotrophic and mixotrophic conditions

Kobayashi, M., Kakizono, T., Yamaguchi, K., Nishio, N., & Nagai, S. (1992) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(92)90261-r · Cited by 178 · see citing works

Nutritionally important carotenoids as consumer products

Berman, J., Zorrilla‐López, U., Farré, G., Zhu, C., Sandmann, G., Twyman, R. M., Capell, T., & Christou, P. (2014) · Phytochemistry Reviews · doi:10.1007/s11101-014-9373-1 · Cited by 175 · see citing works

Production of astaxanthin by Haematococcus pluvialis in a sequential heterotrophic-photoautotrophic culture

Hata, N., Ogbonna, J. C., Hasegawa, Y., Taroda, H., & Tanaka, H. (2001) · Journal of Applied Phycology · doi:10.1023/a:1011921329568 · Cited by 173 · see citing works

Outdoor open thin-layer microalgal photobioreactor: potential productivity

Doucha, J., & Lívanský, K. (2008) · Journal of Applied Phycology · doi:10.1007/s10811-008-9336-2 · Cited by 161 · see citing works

Photo-bioreactor design for microalgae: A review from the aspect of CO2 transfer and conversion

Fu, J., Huang, Y., Liao, Q., Xia, A., Fu, Q., & Zhu, X. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121947 · Cited by 157 · see citing works

Advances in photobioreactors for intensive microalgal production: Configurations, operating strategies and applications

Olivieri, G., Salatino, P., & Marzocchella, A. (2014) · Journal of Chemical Technology &amp; Biotechnology · doi:10.1002/jctb.4218 · Cited by 156 · see citing works

Metabolic Engineering of TCA Cycle for Production of Chemicals

Vuoristo, K. S., Mars, A. E., Sanders, J. P. M., Eggink, G., & Weusthuis, R. A. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.11.002 · Cited by 145 · see citing works

Over-accumulation of astaxanthin in Haematococcus pluvialis through chloroplast genetic engineering

Galarza, J. I., Gimpel, J. A., Rojas, V., Arredondo-Vega, B. O., & Henríquez, V. (2018) · Algal Research · doi:10.1016/j.algal.2018.02.024 · Cited by 143 · see citing works

Metabolite Profiling and Integrative Modeling Reveal Metabolic Constraints for Carbon Partitioning under Nitrogen Starvation in the Green Algae Haematococcus pluvialis

Recht, L., Töpfer, N., Batushansky, A., Sikron, N., Gibon, Y., Fait, A., Nikoloski, Z., Boussiba, S., & Zarka, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.555144 · Cited by 136 · see citing works

Unconventional high-value products from microalgae: A review

Abu‐Ghosh, S., Dubinsky, Z., Verdelho, V., & Iluz, D. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.124895 · Cited by 135 · see citing works

Effects of temperature on the astaxanthin productivity and light harvesting characteristics of the green alga Haematococcus pluvialis

Giannelli, L., Yamada, H., Katsuda, T., & Yamaji, H. (2014) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2014.09.002 · Cited by 125 · see citing works

Enhanced autotrophic astaxanthin production from Haematococcus pluvialis under high temperature via heat stress-driven Haber–Weiss reaction

Hong, M.-E., Hwang, S. K., Chang, W. S., Kim, B. W., Lee, J., & Sim, S. J. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6440-5 · Cited by 125 · see citing works

The effect of temperature on cell growth and astaxanthin accumulation of Haematococcus pluvialis during a light–dark cyclic cultivation

Wan, M., Zhang, J., Hou, D., Fan, J., Li, Y., Huang, J., & Wang, J. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.06.030 · Cited by 124 · see citing works

Induction of salicylic acid (SA) on transcriptional expression of eight carotenoid genes and astaxanthin accumulation in Haematococcus pluvialis

Gao, Z., Meng, C., Zhang, X., Xu, D., Miao, X., Wang, Y., Yang, L. M., Lv, H., Chen, L., & Ye, N. (2012) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2012.07.001 · Cited by 117 · see citing works

De novo synthesis of astaxanthin: From organisms to genes

Fang, N., Wang, C., Liu, X., Zhao, X., Liu, Y., Liu, X., Du, Y., Zhang, Z., & Zhang, H. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.08.016 · Cited by 117 · see citing works

Light-independent, astaxanthin production by the green microalga Haematococcus pluvialis under salt stress

Kobayashi, M., Kurimura, Y., & Tsuji, Y. (1997) · Biotechnology Letters · doi:10.1023/a:1018372900649 · Cited by 116 · see citing works

Alleviation of metabolic bottleneck by combinatorial engineering enhanced astaxanthin synthesis in Saccharomyces cerevisiae

Zhou, P., Xie, W., Li, A., Wang, F., Yao, Z., Bian, Q., Zhu, Y., Yu, H., & Ye, L. (2017) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2017.02.006 · Cited by 115 · see citing works

Sequential Heterotrophy–Dilution–Photoinduction Cultivation of Haematococcus pluvialis for efficient production of astaxanthin

Wan, M., Zhang, Z., Wang, J., Huang, J., Fan, J., Yu, A., Wang, W., & Li, Y. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.09.031 · Cited by 113 · see citing works

Stress-related differential expression of multiple β-carotene ketolase genes in the unicellular green alga Haematococcus pluvialis

Huang, J., Chen, F., & Sandmann, G. (2005) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.09.002 · Cited by 111 · see citing works

Gamma-aminobutyric acid facilitates the simultaneous production of biomass, astaxanthin and lipids in Haematococcus pluvialis under salinity and high-light stress conditions

Li, Q., Zhao, Y., Ding, W., Han, B., Geng, S., Ning, D., Ma, T., & Yu, X. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.124418 · Cited by 107 · see citing works

Methyl jasmonate- or gibberellins A3-induced astaxanthin accumulation is associated with up-regulation of transcription of β-carotene ketolase genes (bkts) in microalga Haematococcus pluvialis

Lu, Y., Jiang, P., Liu, S., Gan, Q., Cui, H., & Qin, S. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.03.072 · Cited by 103 · see citing works

Elevated CO 2 improves lipid accumulation by increasing carbon metabolism in Chlorella sorokiniana

Sun, Z., Chen, Y., & Du, J. (2015) · Plant Biotechnology Journal · doi:10.1111/pbi.12398 · Cited by 102 · see citing works

Butylated hydroxytoluene induces astaxanthin and lipid production in Haematococcus pluvialis under high-light and nitrogen-deficiency conditions

Zhao, Y., Yue, C., Ding, W., Li, T., Xu, J., Zhao, P., Ma, H., & Yu, X. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.06.111 · Cited by 99 · see citing works

Enhanced astaxanthin production from microalga, Haematococcus pluvialis by two-stage perfusion culture with stepwise light irradiation

Park, J. C., Choi, S. P., Hong, M.-E., & Sim, S. J. (2014) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-014-1180-y · Cited by 98 · see citing works

Gene expression profiling of astaxanthin and fatty acid pathways in Haematococcus pluvialis in response to different LED lighting conditions

Ma, R., Thomas‐Hall, S. R., Chua, E. T., Alsenani, F., Eltanahy, E., Netzel, M. E., Netzel, G. A., Lu, Y., & Schenk, P. M. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.11.094 · Cited by 98 · see citing works

The effective photoinduction of Haematococcus pluvialis for accumulating astaxanthin with attached cultivation

Wan, M., Hou, D., Li, Y., Fan, J., Huang, J., Liang, S., Wang, W., Pan, R., Wang, J., & Li, S. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.04.017 · Cited by 97 · see citing works

Biotechnological perspectives on algae: a viable option for next generation biofuels

Khan, S., & Fu, P. (2019) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.09.020 · Cited by 94 · see citing works

Cultivation modes for microbial oil production using oleaginous yeasts – A review

Karamerou, E. E., & Webb, C. (2019) · Biochemical Engineering Journal · doi:10.1016/j.bej.2019.107322 · Cited by 93 · see citing works

Progress in the physicochemical treatment of microalgae biomass for value-added product recovery

Costa, J. A. V., de Freitas, B. B., Moraes, L., Zaparoli, M., & de Morais, M. G. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2019.122727 · Cited by 93 · see citing works

Melatonin enhances astaxanthin accumulation in the green microalga Haematococcus pluvialis by mechanisms possibly related to abiotic stress tolerance

Ding, W., Zhao, P., Peng, J., Zhao, Y., Xu, J., Li, T., Reiter, R. J., Ma, H., & Yu, X. (2018) · Algal Research · doi:10.1016/j.algal.2018.05.021 · Cited by 89 · see citing works

Abscisic acid-dependent algal morphogenesis in the unicellular green alga Haematococcus pluvialis

Kobayashi, M., Hirai, N., Kurimura, Y., Ohigashi, H., & Tsuji, Y. (1997) · Plant Growth Regulation · doi:10.1023/a:1005862809711 · Cited by 86 · see citing works

Enhanced Lycopene Productivity by Manipulation of Carbon Flow to Isopentenyl Diphosphate in Escherichia coli

Vadali, R. V., Fu, Y., Bennett, G. N., & San, K. (2005) · Biotechnology Progress · doi:10.1021/bp050124l · Cited by 84 · see citing works

Regulation of astaxanthin and its intermediates through cloning and genetic transformation of β-carotene ketolase in Haematococcus pluvialis

Shanmugam, K., Chandrashekar, A., Ravishankar, G. A., & Sarada, R. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2015.01.006 · Cited by 83 · see citing works

Coordinated Expression of Astaxanthin Biosynthesis Genes for Improved Astaxanthin Production in Escherichia coli

Gong, Z., Wang, H., Tang, J., Bi, C., Li, Q., & Zhang, X. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05379 · Cited by 82 · see citing works

Primary metabolism is associated with the astaxanthin biosynthesis in the green algae Haematococcus pluvialis under light stress

Hu, C., Cui, D., Sun, X. K., Shi, J., & Xu, N. (2019) · Algal Research · doi:10.1016/j.algal.2019.101768 · Cited by 81 · see citing works

Comparative life cycle assessment of astaxanthin production with Haematococcus pluvialis in different photobioreactor technologies

Onorato, C., & Rösch, C. (2020) · Algal Research · doi:10.1016/j.algal.2020.102005 · Cited by 81 · see citing works

Enhanced protection against oxidative stress in an astaxanthin-overproductionHaematococcusmutant (Chlorophyceae)

Hu, Z., Li, Y., Sommerfeld, M. R., Chen, F., & Hu, Q. (2008) · European Journal of Phycology · doi:10.1080/09670260802227736 · Cited by 79 · see citing works

Differential Contribution of the First Two Enzymes of the MEP Pathway to the Supply of Metabolic Precursors for Carotenoid and Chlorophyll Biosynthesis in Carrot (Daucus carota)

Simpson, K., Quiroz, L. F., Rodrı́guez-Concepción, M., & Stange, C. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01344 · Cited by 78 · see citing works

Bile Acid Sodium Symporter BASS6 Can Transport Glycolate and Is Involved in Photorespiratory Metabolism in Arabidopsis thaliana

South, P. F., Walker, B. J., Cavanagh, A. P., Rolland, V., Badger, M. R., & Ort, D. R. (2017) · The Plant Cell · doi:10.1105/tpc.16.00775 · Cited by 72 · see citing works

Novel application of microalgae platform for biodesalination process: A review

Patel, A. K., Tseng, Y.-S., Singhania, R. R., Chen, C.-W., Chang, J., & Dong, C. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125343 · Cited by 72 · see citing works

Staged cultivation enhances biomass accumulation in the green growth phase of Haematococcus pluvialis

Sun, H., Liu, B., Lu, X., Cheng, K., & Chen, F. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.03.011 · Cited by 71 · see citing works

Melatonin and calcium act synergistically to enhance the coproduction of astaxanthin and lipids in Haematococcus pluvialis under nitrogen deficiency and high light conditions

Cui, J. R., Yu, C., Zhong, D.-B., Zhao, Y., & Yu, X. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123069 · Cited by 71 · see citing works

Transcriptome Analysis in Haematococcus pluvialis: Astaxanthin Induction by Salicylic Acid (SA) and Jasmonic Acid (JA)

Gao, Z., Li, Y., Wu, G., Li, G., Sun, H., Deng, S., Shen, Y., Chen, G., Zhang, R., Meng, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140609 · Cited by 70 · see citing works

Gradient domestication of Haematococcus pluvialis mutant with 15% CO 2 to promote biomass growth and astaxanthin yield

Cheng, J., Li, K., Yang, Z., Lu, H., Zhou, J., & Cen, K. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.05.095 · Cited by 70 · see citing works

Enhancement of astaxanthin production by Haematococcus pluvialis using magnesium aminoclay nanoparticles

Kim, Y.-E., Matter, I. A., Lee, N., Jung, M., Lee, Y., Choi, S.-A., Lee, S. Y., Kim, J. R., & Oh, Y. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123270 · Cited by 68 · see citing works

High-throughput proteomics and metabolomic studies guide re-engineering of metabolic pathways in eukaryotic microalgae: A review

Chakdar, H., Hasan, M. T., Pabbi, S., Nevalainen, H. K. M., & Shukla, P. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.124495 · Cited by 67 · see citing works

Advanced methods for genetic engineering of Haematococcus pluvialis (Chlorophyceae, Volvocales)

Sharon-Gojman, R., Maimon, E., Leu, S., Zarka, A., & Boussiba, S. (2015) · Algal Research · doi:10.1016/j.algal.2015.03.022 · Cited by 66 · see citing works

Astaxanthin overproduction and proteomic analysis of Phaffia rhodozyma under the oxidative stress induced by TiO2

Zhang, J., Li, Q., Liu, J., Lu, Y., Wang, Y., & Wang, Y. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123525 · Cited by 66 · see citing works

CHLOROPLAST GENETIC TOOL FOR THE GREEN MICROALGAE HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE, VOLVOCALES) 1

Gutiérrez, C. L., Gimpel, J. A., Escobar, C., Marshall, S. H., & Henríquez, V. (2012) · Journal of Phycology · doi:10.1111/j.1529-8817.2012.01178.x · Cited by 64 · see citing works

A ζ-carotene desaturase gene, IbZDS , increases β-carotene and lutein contents and enhances salt tolerance in transgenic sweetpotato

Li, R., Kang, C., Song, X., Yu, L., Liu, D., He, S., Zhai, H., & Liu, Q. (2017) · Plant Science · doi:10.1016/j.plantsci.2017.05.014 · Cited by 64 · see citing works

Isolation and Characterization of a Novel, Highly Selective Astaxanthin-Producing Marine Bacterium

Asker, D. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b03556 · Cited by 63 · see citing works

A strategy for stimulating astaxanthin and lipid production in Haematococcus pluvialis by exogenous glycerol application under low light

Zhang, L., Zhang, C., Liu, J., & Yang, N. (2019) · Algal Research · doi:10.1016/j.algal.2019.101779 · Cited by 63 · see citing works

Enhancement of short-chain fatty acids production from microalgae by potassium ferrate addition: Feasibility, mechanisms and implications

Wang, Y., Liu, X., Liu, Y., Wang, D., Xu, Q., Li, X., Yang, Q. X., Wang, Q., Ni, B., & Chen, H. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.124266 · Cited by 63 · see citing works

Comparative physiological and metabolomic analyses of the hyper-accumulation of astaxanthin and lipids in Haematococcus pluvialis upon treatment with butylated hydroxyanisole

Ding, W., Li, Q., Han, B., Zhao, Y., Geng, S., Ning, D., Ma, T., & Yu, X. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122002 · Cited by 60 · see citing works

Integration of physiological and metabolomic profiles to elucidate the regulatory mechanisms underlying the stimulatory effect of melatonin on astaxanthin and lipids coproduction in Haematococcus pluvialis under inductive stress conditions

Zhao, Y., Wang, H.-P., Yu, C., Ding, W., Han, B., Geng, S., Ning, D., Ma, T., & Yu, X. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2020.124150 · Cited by 59 · see citing works

Fed-batch culture of astaxanthin-rich Haematococcus pluvialis by exponential nutrient feeding and stepwise light supplementation

Kang, C. D., Han, S. J., Choi, S. P., & Sim, S. J. (2009) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-009-0362-5 · Cited by 57 · see citing works

Ethanol induced jasmonate pathway promotes astaxanthin hyperaccumulation in Haematococcus pluvialis

Liu, Y., Alimujiang, A., Wang, X., Luo, S.-W., Balamurugan, S., Yang, W., Liu, J., Zhang, L., & Li, H. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121720 · Cited by 57 · see citing works

Effects of C5 organic carbon and light on growth and cell activity of Haematococcus pluvialis under mixotrophic conditions

Pang, N., & Chen, S. (2016) · Algal Research · doi:10.1016/j.algal.2016.12.003 · Cited by 55 · see citing works

Transcriptome sequencing and metabolic pathways of astaxanthin accumulated in Haematococcus pluvialis mutant under 15% CO2

Cheng, J., Li, K., Zhu, Y., Yang, W., Zhou, J., & Cen, K. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.12.084 · Cited by 54 · see citing works

Selectively biorefining astaxanthin and triacylglycerol co-products from microalgae with supercritical carbon dioxide extraction

Kwan, T. A., Kwan, S. E., Peccia, J., & Zimmerman, J. B. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.08.081 · Cited by 54 · see citing works

Effect of the ethylene precursor, 1-aminocyclopropane-1-carboxylic acid on different growth stages of Haematococcus pluvialis

Vo, T.-T., Lee, C., Han, S., Kim, J. Y., Kim, S., & Choi, Y.-E. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.08.046 · Cited by 52 · see citing works

Scaling-up of Haematococcus pluvialis production in stirred tank photobioreactor

Deniz, I. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123434 · Cited by 50 · see citing works

Harnessing C/N balance of Chromochloris zofingiensis to overcome the potential conflict in microalgal production

Sun, H., Ren, Y., Mao, X., Li, X., Zhang, H., Lao, Y., & Chen, F. (2020) · Communications Biology · doi:10.1038/s42003-020-0900-x · Cited by 49 · see citing works

A novel fed-batch strategy to boost cyst cells production based on the understanding of intracellular carbon and nitrogen metabolism in Haematococcus pluvialis

Lü, Z., Zheng, L., Liu, J., Dai, J., & Song, L. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121744 · Cited by 48 · see citing works

Enhanced lipid production by Chlorella pyrenoidosa through magnetic field pretreatment of wastewater and treatment of microalgae-wastewater culture solution: Magnetic field treatment modes and conditions

Feng, X., Chen, Y., Lv, J., Han, S.-F., Tu, R., Zhou, X., Jin, W., & Ren, N. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123102 · Cited by 47 · see citing works

Boost carbon availability and value in algal cell for economic deployment of biomass

Sun, H., Li, X., Ren, Y., Zhang, H., Mao, X., Lao, Y., Wang, X., & Chen, F. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122640 · Cited by 46 · see citing works

Transcriptome analysis reveals pathways responsible for the promoting effect of sucrose on astaxanthin accumulation in Haematococcus pluvialis under high light condition

Du, F., Hu, C., Sun, X. K., & Xu, N. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735757 · Cited by 45 · see citing works

A mutant allele of ζ-carotene isomerase (Z-ISO) is associated with the yellow pigmentation of the “Pinalate” sweet orange mutant and reveals new insights into its role in fruit carotenogenesis

Rodrigo, M. J., Lado, J., Alós, E., Alquézar, B., Dery, O., Hirschberg, J., & Zacarı́as, L. (2019) · BMC Plant Biology · doi:10.1186/s12870-019-2078-2 · Cited by 44 · see citing works

Exogenous γ-aminobutyric acid promotes biomass and astaxanthin production in Haematococcus pluvialis

Li, L., Chen, Z., & Huang, Q. (2020) · Algal Research · doi:10.1016/j.algal.2020.102089 · Cited by 44 · see citing works

Optimal design of scalable photo-bioreactor for phototropic culturing of Haematococcus pluvialis

Yoo, J. J., Choi, S. P., Kim, B. W., & Sim, S. J. (2011) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-011-0616-x · Cited by 42 · see citing works

Influence of Photobioreactor Set-up on the Survival of Microalgae Inoculum

Bani, A., Fernandez, F. G. A., D'Imporzano, G., Parati, K., & Adani, F. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2020.124408 · Cited by 42 · see citing works

The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast

Corkins, M. E., Wilson, S., Cocuron, J., Alonso, A. P., & Bird, A. J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.798488 · Cited by 41 · see citing works

Paving the way towards precise and safe CRISPR genome editing

Śledziński, P., Dabrowska, M., Nowaczyk, M., & Olejniczak, M. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107737 · Cited by 41 · see citing works

Disodium 2-oxoglutarate promotes carbon flux into astaxanthin and fatty acid biosynthesis pathways in Haematococcus

Lü, Z., Dai, J., Zheng, L., Teng, Z., Zhang, Q., Qiu, D., & Song, L. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122612 · Cited by 40 · see citing works

Role of copper in the enhancement of astaxanthin and lipid coaccumulation in Haematococcus pluvialis exposed to abiotic stress conditions

Guo, H., Li, T., Zhao, Y., & Yu, X. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125265 · Cited by 39 · see citing works

Unveiling the underlying molecular basis of astaxanthin accumulation in Haematococcus through integrative metabolomic-transcriptomic analysis

Hoys, C., Romero–Losada, A. B., del Río, E., Guerrero, M. G., Romero–Campero, F. J., & García‐González, M. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125150 · Cited by 38 · see citing works

Metabolic engineering of Synechocystis sp. PCC6803 to produce astaxanthin

Liu, Y., Cui, Y., Chen, J., Qin, S., & Chen, G. (2019) · Algal Research · doi:10.1016/j.algal.2019.101679 · Cited by 36 · see citing works

Enhancement of astaxanthin biosynthesis in Haematococcus pluvialis via inhibition of autophagy by 3-methyladenine under high light

Wang, X., Song, Y., Liu, B., Wei, H., Li, R., Cui, H., Li, R., & Jia, X. (2020) · Algal Research · doi:10.1016/j.algal.2020.101991 · Cited by 35 · see citing works

Stepwise-incremental physicochemical factors induced acclimation and tolerance in oleaginous microalgae to crucial outdoor stresses and improved properties as biodiesel feedstocks

Maneechote, W., & Cheirsilp, B. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.124850 · Cited by 35 · see citing works

Application of surfactants for controlling destructive fungus contamination in mass cultivation of Haematococcus pluvialis

Ding, Y. M., Zhang, A., Wen, X., Wang, Z., Wang, K., Geng, Y., & Li, Y. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.124025 · Cited by 34 · see citing works

Enhancement of linoleic acid content stimulates astaxanthin esterification in Coelastrum sp.

Liu, Z., Hou, Y., He, C., Wang, X., Chen, S., Huang, Z., & Chen, F. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122649 · Cited by 31 · see citing works

Expression of carotenogenic genes and carotenoid production in Haematococcus pluvialis under the influence of carotenoid and fatty acid synthesis inhibitors

Raman, V., Sarada, R., & Ravishankar, G. A. (2009) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2009.05.005 · Cited by 30 · see citing works

Rapid colour changes in Euglena sanguinea (Euglenophyceae) caused by internal lipid globule migration

Laza‐Martínez, A., Fernández‐Marín, B., & García‐Plazaola, J. I. (2018) · European Journal of Phycology · doi:10.1080/09670262.2018.1513571 · Cited by 29 · see citing works

Effect of linoleic acid and methyl jasmonate on astaxanthin content of Scenedesmus acutus and Chlorella sorokiniana under heterotrophic cultivation and salt shock conditions

Khalili, Z., Jalili, H., Noroozi, M., & Amrane, A. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-01782-0 · Cited by 27 · see citing works

Systematic metabolic tools reveal underlying mechanism of product biosynthesis in Chromochloris zofingiensis

Sun, H., Ren, Y., Fan, Y., Lu, X., Zhao, W., & Chen, F. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125406 · Cited by 27 · see citing works

Manipulation of trophic capacities in Haematococcus pluvialis enables low-light mediated growth on glucose and astaxanthin formation in the dark

Waissman-Levy, N., Leu, S., Khozin‐Goldberg, I., & Boussiba, S. (2019) · Algal Research · doi:10.1016/j.algal.2019.101497 · Cited by 26 · see citing works

Astaxanthin biosynthesis in transgenic Dunaliella salina (Chlorophyceae) enhanced tolerance to high irradiation stress

Chen, Y., Bi, C., Zhang, J., Hou, H., & Gong, Z. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.07.008 · Cited by 25 · see citing works

Cloning and identification of a novel β-carotene hydroxylase gene from Haematococcus pluvialis and its function in Escherichia coli

Huang, D., Liu, W., Li, A., Hu, Z., Wang, J., & Wang, C. (2021) · Algal Research · doi:10.1016/j.algal.2021.102245 · Cited by 25 · see citing works

The interrelation between photorespiration and astaxanthin accumulation in Haematococcus pluvialis using metabolomic analysis

Zhang, C., Zhang, L., & Liu, J. (2019) · Algal Research · doi:10.1016/j.algal.2019.101520 · Cited by 24 · see citing works

Does Haematococcus pluvialis need to sleep?

Domı́nguez, A., Pereira, S., & Otero, A. (2019) · Algal Research · doi:10.1016/j.algal.2019.101722 · Cited by 23 · see citing works

Differential role of the two ζ-carotene desaturase paralogs in carrot (Daucus carota): ZDS1 is a functional gene essential for plant development and carotenoid synthesis

Flores‐Ortiz, C., Alvarez, L. M., Undurraga, A., Arias-G, D., Durán, F., Wegener, G., & Stange, C. (2019) · Plant Science · doi:10.1016/j.plantsci.2019.110327 · Cited by 23 · see citing works

Functional Characterization of a Missing Branch Component in Haematococcus pluvialis for Control of Algal Carotenoid Biosynthesis

Lao, Y., Jin, H., Zhou, J., Zhang, H. J., & Cai, Z. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01341 · Cited by 22 · see citing works

Simultaneous improvement of astaxanthin and lipid production of Haematococcus pluvialis by using walnut shell extracts

Yu, C., Li, X., Han, B., Zhao, Y., Geng, S., Ning, D., Ma, T., & Yu, X. (2020) · Algal Research · doi:10.1016/j.algal.2020.102171 · Cited by 22 · see citing works

Discovery of Geranylgeranyl Pyrophosphate Synthase (GGPPS) Paralogs from Haematococcus pluvialis Based on Iso-Seq Analysis and Their Function on Astaxanthin Biosynthesis

Huang, D., Liu, W., Li, A., Wang, C., & Hu, Z. (2019) · Marine Drugs · doi:10.3390/md17120696 · Cited by 20 · see citing works

Stimulation of biomass and astaxanthin accumulation in Haematococcus pluvialis using low-temperature plasma (LTP)

Chen, Z., Li, L., Zhang, H., & Huang, Q. (2020) · Bioresource Technology Reports · doi:10.1016/j.biteb.2020.100385 · Cited by 19 · see citing works

Identification of microRNAs involved in astaxanthin accumulation responding to high light and high sodium acetate (NaAC) stresses in Haematococcus pluvialis

Wang, X., Miao, X., Gao, C., Cui, Y., Sun, F., Fan, J., Gao, Z., & Meng, C. (2021) · Algal Research · doi:10.1016/j.algal.2020.102179 · Cited by 15 · see citing works

Carotenoid Production from Microalgae: Biosynthesis, Salinity Responses and Novel Biotechnologies

Ren, Y., Sun, H., Deng, J., Huang, J., & Chen, F. (2021) · Marine Drugs · doi:10.3390/md19120713 · Cited by 193 · see citing works

Recent advancements in astaxanthin production from microalgae: A review

Patel, A. K., Tambat, V. S., Chen, C., Chauhan, A. S., Kumar, P., Vadrale, A. P., Huang, C.-Y., Dong, C., & Singhania, R. R. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.128030 · Cited by 179 · see citing works

Cell disruption and astaxanthin extraction from Haematococcus pluvialis: Recent advances

Kim, B., Lee, S. Y., Narasimhan, A. L., Kim, S., & Oh, Y. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126124 · Cited by 143 · see citing works

The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions

Bjørklund, G., Gasmi, A., Lenchyk, L. V., Shanaida, M., Zafar, S., Mujawdiya, P. K., Lysiuk, R., Antonyak, H., Noor, S., Akram, M., et al. (2022) · Molecules · doi:10.3390/molecules27217167 · Cited by 119 · see citing works

Astaxanthin from microalgae: A review on structure, biosynthesis, production strategies and application

Debnath, T., Bandyopadhyay, T. K., Vanitha, K., Bobby, M. N., Tiwari, O. N., Bhunia, B., & Muthuraj, M. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113841 · Cited by 101 · see citing works

Chemical inducers regulate ROS signalling to stimulate astaxanthin production in Haematococcus pluvialis under environmental stresses: A review

Li, Q., Li, L., Zhang, Y., Gao, H., Zhao, Y., & Yu, X. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.04.014 · Cited by 98 · see citing works

Lutein production from microalgae: A review

Fu, Y., Wang, Y., Yi, L., Liu, J., Yang, S., Liu, B., Chen, F., & Sun, H. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.128875 · Cited by 87 · see citing works

The Structure, Functions and Potential Medicinal Effects of Chlorophylls Derived from Microalgae

Sun, D., Wu, S., Li, X., Ge, B., Zhou, C., Yan, X., Ruan, R. R., & Cheng, P. (2024) · Marine Drugs · doi:10.3390/md22020065 · Cited by 81 · see citing works

Challenges in Functional Food Products with the Incorporation of Some Microalgae

Çelekli, A., Özbal, B., & Bozkurt, H. (2024) · Foods · doi:10.3390/foods13050725 · Cited by 80 · see citing works

Research trends and market opportunities of microalgal biorefinery technologies from circular bioeconomy perspectives

Behera, B., Mari Selvam, S., & Balasubramanian, P. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.127038 · Cited by 73 · see citing works

Advances in Genetic Engineering in Improving Photosynthesis and Microalgal Productivity

Hu, J., Wang, D., Chen, H., & Wang, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031898 · Cited by 67 · see citing works

The effects of acetate and glucose on carbon fixation and carbon utilization in mixotrophy of Haematococcus pluvialis

Joun, J., Sirohi, R., & Sim, S. J. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.128218 · Cited by 64 · see citing works

Screening of microalgae species and evaluation of algal-lipid stimulation strategies for biodiesel production

Yang, Y., Ge, S., Pan, Y., Qian, W., Wang, S., Zhang, J., & Zhuang, L.-L. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159281 · Cited by 57 · see citing works

Directed evolution of the fusion enzyme for improving astaxanthin biosynthesis in Saccharomyces cerevisiae

Ding, Y.-W., Lü, C., zheng, Y., Ma, H.-Z., Jin, J., Jia, B., & Yuan, Y. (2022) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2022.10.005 · Cited by 54 · see citing works

Astaxanthin with different configurations: sources, activity, post modification, and application in foods

Sun, J., Yan, J., Dong, H., Gao, K., Yu, K., He, C., & Mao, X. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100955 · Cited by 52 · see citing works

From present to prosperity: assessing the current status and envisioning opportunities in the industrial-scale cultivation of Haematococcus pluvialis for astaxanthin production

Ariyadasa, T. U., Thevarajah, B., Anthonio, R. A. D. P., Nimarshana, P. H. V., & Wasath, W. A. J. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-023-09906-8 · Cited by 48 · see citing works

Microbial Lipid Based Biorefinery Concepts: A Review of Status and Prospects

Silva, J. D. M. E., Martins, L. H. D. S., Moreira, D. K. T., Silva, L. D. P., Barbosa, P. D. P. M., Komesu, A., Ferreira, N. R., & de Oliveira, J. A. R. (2023) · Foods · doi:10.3390/foods12102074 · Cited by 44 · see citing works

Supercritical fluid extraction of astaxanthin-rich extracts from Haematococcus pluvialis: Economic assessment

Vardanega, R., Mezquita, P. C., & Veggi, P. C. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.127706 · Cited by 43 · see citing works

Advancements of astaxanthin production in Haematococcus pluvialis: Update insight and way forward

Cui, H., Zhu, X., Xiao, Y., Li, S., Wang, K., Wei, L., Li, R., & Qin, S. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108519 · Cited by 45 · see citing works

Unlocking the potential of microalgae bio-factories for carbon dioxide mitigation: A comprehensive exploration of recent advances, key challenges, and energy-economic insights

Dasan, Y. K., Lam, M. K., Chai, Y. H., Lim, J. W., Ho, Y., Tan, I. S., Lau, S. Y., Show, P. L., & Lee, K. T. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.129094 · Cited by 40 · see citing works

Pickering emulsion stabilized by Haematococcus pluvialis protein particles and its application in dumpling stuffing

Liu, C., Cheng, S., Wang, H., & Tan, M. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112957 · Cited by 41 · see citing works

Astaxanthin: A comprehensive review of synthesis, biological activities and applications

Sun, L., Li, Y., Yang, A., Xie, M., Xiong, R., & Huang, C. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144847 · Cited by 39 · see citing works

Process intensification of ultrasound assisted deep eutectic solvent-based extraction of astaxanthin-rich extract derived from the non-conventional bacterium Paracoccus carotinifaciens

Paz, A. V. C., Rigano, F., Cafarella, C., Tropea, A., Mondello, L., Galán, J. P. M., Ahmad, M., Mustafa, A., Farias, F. O., Córdova, A., et al. (2024) · Separation and Purification Technology · doi:10.1016/j.seppur.2024.126674 · Cited by 35 · see citing works

A review of natural astaxanthin production in a circular bioeconomy context using Paracoccus carotinifaciens

Mussagy, C. U., & Dufossé, L. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.128499 · Cited by 36 · see citing works

Astaxanthin alleviates lipopolysaccharide-induced acute lung injury by suppressing ferroptosis

Dong, X., Li, D., Fang, Z., Zhang, C., Wang, J., & Wan, X. (2023) · Food & Function · doi:10.1039/d3fo01727c · Cited by 34 · see citing works

Industrial Production of Functional Foods for Human Health and Sustainability

Yuan, X., Zhong, M., Huang, X., Hussain, Z., Ren, M., & Xie, X. (2024) · Foods · doi:10.3390/foods13223546 · Cited by 48 · see citing works

Green Synthesis of Silver Nanoparticles Using the Cell-Free Supernatant of Haematococcus pluvialis Culture

Savvidou, M. G., Kontari, E., Kalantzi, S., & Mamma, D. (2023) · Materials · doi:10.3390/ma17010187 · Cited by 33 · see citing works

Advances in capturing carbon and producing bioplastics through the microalgal approach towards a sustainable future: A review

Irfan, F., Tasnim, N., Razzak, S. A., & Uddin, S. (2024) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2024.144576 · Cited by 35 · see citing works

Extraction of Valuable Biomolecules from the Microalga Haematococcus pluvialis Assisted by Electrotechnologies

Gherabli, A., Grimi, N., Lemaire, J., Vorobiev, E., & Lebovka, N. (2023) · Molecules · doi:10.3390/molecules28052089 · Cited by 31 · see citing works

Enhancement of astaxanthin bioaccessibility by encapsulation in liposomes: an in vitro study

Pan, L., Meng, H., Li, J., Liu, Z., Zhang, D., Liu, Z., Zhao, Q., & Xu, F. (2024) · Molecules · doi:10.3390/molecules29081687 · Cited by 30 · see citing works

Pathway Engineering, Re-targeting, and Synthetic Scaffolding Improve the Production of Squalene in Plants

Bibik, J. D., Weraduwage, S. M., Banerjee, A., Robertson, K., Espinoza‐Corral, R., Sharkey, T. D., Lundquist, P. K., & Hamberger, B. R. (2022) · ACS Synthetic Biology · doi:10.1021/acssynbio.2c00051 · Cited by 28 · see citing works

Recent Advances in Algae-Derived Biofuels and Bioactive Compounds

Feng, S., Kang, K., Salaudeen, S. A., Ahmadi, A., He, Q. S., & Hu, Y. (2022) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.1c04039 · Cited by 28 · see citing works

Preparation of carrier-free astaxanthin nanoparticles with improved antioxidant capacity

Yu, F., Chen, J., Wei, Z., Zhu, P., Qing, Q., Li, B., Chen, H., Lin, W., Yang, H., Qi, Z., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1022323 · Cited by 26 · see citing works

Algal biorefinery towards decarbonization: Economic and environmental consideration

Sharmila, V. G., Banu, J. R., Kumar, M. D., Kumar, S. A., & Kumar, G. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.128103 · Cited by 25 · see citing works

Bet hedging in a unicellular microalga

Tang, S., Liu, Y., Zhu, J., Cheng, X., Liu, L., Hammerschmidt, K., Zhou, J., & Cai, Z. (2024) · Nature Communications · doi:10.1038/s41467-024-46297-6 · Cited by 24 · see citing works

Molecular approaches to enhance astaxanthin biosynthesis; future outlook: engineering of transcription factors in Haematococcus pluvialis

Kayani, S., Rahman, S.-U., Shen, Q., Cui, Y., Liu, W., Hu, X., Zhu, F., & Huo, S. (2023) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2023.2208284 · Cited by 23 · see citing works

Synchronous enhancement of astaxanthin and lipid accumulation in Haematococcus lacustris through co-mutation of ethanol and atmospheric and room temperature plasma: Exploration of characteristics and underlying mechanisms

Ma, Y., Sun, X., Sun, Y., Li, H., Li, H., & Jiao, X. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.130305 · Cited by 23 · see citing works

Astaxanthin in cancer therapy and prevention (Review)

Copat, C., Favara, C., Tomasello, M. F., Sica, C., Grasso, A., Domı́nguez, H., Conti, G. O., & Ferrante, M. (2025) · Biomedical Reports · doi:10.3892/br.2025.1944 · Cited by 24 · see citing works

Astaxanthin: An overview of its sources, extraction methods, encapsulation techniques, characterization, and bioavailability

Oninku, B., Lomas, M. W., Burr, G., & Aryee, A. N. A. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101869 · Cited by 21 · see citing works

Co-culture of microalgae and bacteria for the production of bioactive compounds

Lopes, L. D. B., Soares, R. C., de Freitas, R. M., Amarante, D. O., Carvalho, F. D. S. D. S., Cavalcante, K. M. D. S. P., de Sousa, O. V., & de Menezes, F. G. R. (2025) · Annals of Microbiology · doi:10.1186/s13213-025-01804-y · Cited by 21 · see citing works

Pulsed Electric Field–Assisted Cell Permeabilization of Microalgae (Haematococcus pluvialis) for Milking of Value-Added Compounds

Ahirwar, A., Khan, M. J., Sirotiya, V., Mourya, M., Rai, A., Schoefs, B., Marchand, J., Varjani, S., & Vinayak, V. (2022) · BioEnergy Research · doi:10.1007/s12155-022-10414-4 · Cited by 21 · see citing works

Enhancement of Astaxanthin and Fatty Acid Production in Haematococcus pluvialis Using Strigolactone

Mahadi, R., Vahisan, L. P. S., Ilhamsyah, D. P. A., Kim, S., Kim, B., Lee, N., & Oh, Y. (2022) · Applied Sciences · doi:10.3390/app12041791 · Cited by 19 · see citing works

Effects of Four Organic Carbon Sources on the Growth and Astaxanthin Accumulation of Haematococcus lacustris

Byeon, H., An, Y., Kim, T., Rayamajhi, V., Lee, J., Shin, H., & Jung, S.-M. (2023) · Life · doi:10.3390/life14010029 · Cited by 19 · see citing works

Genetic engineering of Haematococcus pluvialis microalgae for the enhancement of astaxanthin production: A review

Gu, Y. B. L., Teo, M. Y. M., In, L. L. A., Shimizu, K., Chae, K., Tran, T. N. T., & Khoo, K. S. (2024) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2024.103298 · Cited by 22 · see citing works

Genetic Engineering and Innovative Cultivation Strategies for Enhancing the Lutein Production in Microalgae

Coleman, B., Vereecke, E., LAERE, K. V., Novoveská, L., & Robbens, J. (2024) · Marine Drugs · doi:10.3390/md22080329 · Cited by 20 · see citing works

Enhancing the biochemical growth of Haematococcus pluvialis by mitigation of broad-spectrum light stress in wastewater cultures

Mourya, M., Khan, M. J., Sirotiya, V., Ahirwar, A., Schoefs, B., Marchand, J., Varjani, S., & Vinayak, V. (2023) · RSC Advances · doi:10.1039/d3ra01530k · Cited by 18 · see citing works

Multifunctional Nanotherapeutics with Long-Acting Release against Macular Degeneration by Minimally Invasive Administration

Chang, W., Lv, X., Zhu, J., Shen, J., Yao, J., Liu, Z., & Chen, Q. (2024) · ACS Nano · doi:10.1021/acsnano.4c04494 · Cited by 18 · see citing works

Novel insights into saline stress on photosynthetic activity and astaxanthin production of Haematococcus pluvialis

Jin, C., You, J., Zhou, Z., Liu, Q., & Zhou, X. (2024) · Journal of Oceanology and Limnology · doi:10.1007/s00343-024-4104-y · Cited by 17 · see citing works

Astaxanthin from Haematococcus pluvialis and Chromochloris zofingiensis: Biosynthetic Pathways, Engineering Strategies, and Industrial Prospects

Yang, S., Lu, X., Wang, J., Liu, Y., Nie, M., Liu, J., & Sun, H. (2025) · Marine Drugs · doi:10.3390/md23120485 · Cited by 17 · see citing works

Solubility and Stability of Carotenoids in Ammonium- and Phosphonium-Based Ionic Liquids: Effect of Solvent Nature, Temperature and Water

Cheng, W., Xian, F., Zhou, Z., Hu, K., & Gao, J. (2023) · Molecules · doi:10.3390/molecules28083618 · Cited by 17 · see citing works

Assessment of thraustochytrids potential for carotenoids, terpenoids and polyunsaturated fatty acids biorefinery

Chauhan, A. S., Chen, C., Yadav, H., Binod, P., Singhania, R. R., Dong, C., & Patel, A. K. (2023) · Journal of Food Science and Technology · doi:10.1007/s13197-023-05740-0 · Cited by 17 · see citing works

Haematococcus lacustris genome assembly and annotation reveal diploid genetic traits and stress-induced gene expression patterns

Marcolungo, L., Bellamoli, F., Cecchin, M., Lopatriello, G., Rossato, M., Cosentino, E., Rombauts, S., Delledonne, M., & Ballottari, M. (2024) · Algal Research · doi:10.1016/j.algal.2024.103567 · Cited by 15 · see citing works

Two-stage carbon sequestration by Haematococcus pluvialis: Integrated research from small-scale to pilot-scale cultivation and data quality monitoring

Guo, S., Li, F., Wang, J., Zhou, H., Yuan, Z., Yang, R., Ke, H., Chen, H., Wang, C., & Cai, M. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.131828 · Cited by 15 · see citing works

Extraction of astaxanthin from Haematococcus pluvialis utilizing acidic deep eutectic solvents: A comparison with ionic liquids and organic solvents

Cheng, W., Yu, Q., Huang, H.-L., Hu, K., & Gao, J. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.113005 · Cited by 16 · see citing works

Astaxanthin: a nature’s versatile compound utilized for diverse applications and its therapeutic effects

Bharti, A., Hooda, V., Jain, U., & Chauhan, N. (2025) · 3 Biotech · doi:10.1007/s13205-025-04241-5 · Cited by 16 · see citing works

Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology

Rambaldi, A., Paris, F., Marrazzo, P., Costa, R., Ratti, S., & Alviano, F. (2025) · Marine Drugs · doi:10.3390/md23060235 · Cited by 13 · see citing works

Diversity, astaxanthin production, and genomic analysis of Rhodotorula paludigena SP9-15

Phuengjayaem, S., Kingkaew, E., Hoondee, P., Rojsitthisak, P., Sritularak, B., Thitikornpong, W., Thompho, S., Pornputtapong, N., & Tanasupawat, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18280 · Cited by 13 · see citing works

Buffering culture solution significantly improves astaxanthin production efficiency of mixotrophic Haematococcus pluvialis

Lv, R., Liu, K., Chen, F., Xing, H., Xu, N., Sun, X. K., & Hu, C. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.127175 · Cited by 13 · see citing works

Photosynthetic activity and astaxanthin production of Haematococcus pluvialis regulated by manipulated light quality

Jin, C., Zhou, Z., Zhu, Y., Liu, Q., & Zhou, X. (2023) · Aquaculture International · doi:10.1007/s10499-023-01341-y · Cited by 12 · see citing works

Astaxanthin biosynthesis for functional food development and space missions

Xie, X., Zhong, M., Huang, X., Yuan, X., Mahna, N., Mussagy, C. U., & Ren, M. (2024) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2024.2410364 · Cited by 12 · see citing works

One-Pot, Water-Based Disruption of Cell Walls and Astaxanthin Extraction from Haematococcus pluvialis by Mechanochemistry

Su, W., Xu, W., & Su, W. (2023) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.2c06726 · Cited by 11 · see citing works

Genomic Insight and Optimization of Astaxanthin Production from a New Rhodotorula sp. CP72-2

Kingkaew, E., Tedsree, N., Phuengjayaem, S., Rojsitthisak, P., Sritularak, B., Thitikornpong, W., Thompho, S., Mhuantong, W., & Tanasupawat, S. (2023) · Fermentation · doi:10.3390/fermentation9060501 · Cited by 11 · see citing works

Transcriptomics and metabonomics reveal molecular mechanisms promoting lipid production in Haematococcus pluvialis co-mutated by atmospheric and room temperature plasma with ethanol

Turab, A., Sun, X., Yihua, M., Elahi, A., Batool, N., Li, P., Majeed, Y., & Sun, Y. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.131958 · Cited by 13 · see citing works

Efficient astaxanthin production: Advanced strategies to improve microbial fermentation

Zhou, Q., Yang, J., Jiang, W., Zhang, W., Chen, M., Jiang, Y., & Xin, F. (2024) · Biofuels Bioproducts and Biorefining · doi:10.1002/bbb.2709 · Cited by 11 · see citing works

Astaxanthin: nature’s multifunctional molecule, natural sources, health benefits, and process advancements

Tambat, V. S., Singhania, R. R., Sumathi, Y., Chen, C., Dong, C., Michaud, P., & Patel, A. K. (2025) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2025.2537816 · Cited by 12 · see citing works

The role of key genes in astaxanthin biosynthesis in Phaffia rhodozyma by transcript level and gene knockout

Li, Z., Chen, L., Yang, H., Li, T., Du, X., He, N., Jiang, Z., Li, L., & Ni, H. (2021) · Process Biochemistry · doi:10.1016/j.procbio.2021.12.029 · Cited by 11 · see citing works

Oxidative stress facilitates infection of the unicellular alga Haematococcus pluvialis by the fungus Paraphysoderma sedebokerense

Yan, H., Ma, H., Li, Y., Zhao, L., Lin, J., Jia, Q., Hu, Q., & Han, D. (2022) · Biotechnology for Biofuels and Bioproducts · doi:10.1186/s13068-022-02140-y · Cited by 11 · see citing works

Differential Responses to UV-A Stress Recorded in Carotenogenic Microalgae Haematococcus rubicundus, Bracteacoccus aggregatus, and Deasonia sp.

Александрович, Ч. К., Shibzukhova, K. A., Lobakova, E. S., & Solovchenko, A. E. (2022) · Plants · doi:10.3390/plants11111431 · Cited by 11 · see citing works

Enhancing astaxanthin accumulation in immobilized Haematococcus pluvialis via alginate hydrogel membrane

Zhang, Y., Wang, X., Su, D., Zhao, L., Leng, K., Miao, J., & Yu, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139145 · Cited by 10 · see citing works

Research of Fluridone’s Effects on Growth and Pigment Accumulation of Haematococcus pluvialis Based on Transcriptome Sequencing

Sun, J.-P., Zan, J., & Zang, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063122 · Cited by 10 · see citing works

Folate-mediated one-carbon metabolism as a potential antifungal target for the sustainable cultivation of microalga Haematococcus pluvialis

Yan, H., Ding, M., Lin, J., Zhao, L., Han, D., & Hu, Q. (2023) · Biotechnology for Biofuels and Bioproducts · doi:10.1186/s13068-023-02353-9 · Cited by 10 · see citing works

Dispersive phase microscopy incorporated with droplet-based microfluidics for biofactory-on-a-chip

Luo, Y., Huang, Y., Li, Y., Duan, X., Jiang, Y., Wang, C., Fang, J., Xi, L., Nguyen, N., & Song, C. (2023) · Lab on a Chip · doi:10.1039/d3lc00127j · Cited by 10 · see citing works

A Study on the Effect of Various Media and the Supplementation of Organic Compounds on the Enhanced Production of Astaxanthin from Haematococcus lacustris (Girod—Chantrans) Rostafinski (Chlorophyta)

Rayamajhi, V., An, Y., Byeon, H., Lee, J., Kim, T., Choi, A., Lee, J., Lee, K., Kim, C., Shin, H., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12061040 · Cited by 9 · see citing works

Synergistic and stepwise treatment of resveratrol and catechol in Haematococcus pluvialis for the overproduction of biomass and astaxanthin

Qiu, J.-F., Yang, Y.-C., Li, R., Jiao, Y.-H., Mou, J., Yang, W.-D., Lin, C. S. K., Li, H.-Y., & Wang, X. (2024) · Biotechnology for Biofuels and Bioproducts · doi:10.1186/s13068-024-02527-z · Cited by 9 · see citing works

Rhodoxanthin: The new hit of the natural carotenoids market?

Mussagy, C. U., Giuffrida, D., Meléndez‐Martínez, A. J., & Dufossé, L. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.04.016 · Cited by 9 · see citing works

Commercialization of Haematococcus-Based Products: Current Status and Future Forecast

Saikia, D. K., Ahmed, R., Chikkaputtaiah, C., & Velmurugan, N. (2023) · Springer eBooks · doi:10.1007/978-981-99-2901-6_18 · Cited by 8 · see citing works

High-Purity Fucoxanthin Can Be Efficiently Prepared from Isochrysis zhangjiangensis by Ethanol-Based Green Method Coupled with Octadecylsilyl (ODS) Column Chromatography

Zhuang, G., Ye, Y., Zhao, J., Zhou, C., Zhu, J., Li, Y., Zhang, J., & Yan, X. (2022) · Marine Drugs · doi:10.3390/md20080510 · Cited by 8 · see citing works

Microalgal nutraceuticals: unravelling solution to food-health nexus

Garg, D., Bala, S., & Phutela, U. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-023-09888-7 · Cited by 7 · see citing works

Biotechnological Applications of Haematococcus: Future Perspectives

Yarkent, Ç., & Öncel, S. Ş. (2023) · Springer eBooks · doi:10.1007/978-981-99-2901-6_17 · Cited by 7 · see citing works

Xanthosine-mediated modulation of Haematococcus pluvialis growth and stress response under high light: Insights from physiological and transcriptome analysis

Liu, K., Lv, R., Xing, H., Sun, X. K., Xu, N., Hu, C., & Zhang, L. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.742156 · Cited by 7 · see citing works

The concurrent production of lipid and lutein in Chlorella vulgaris triggered by light coupling nitrogen tactics

Li, Y., Qi, Z., Fan, Y., Tang, Y., & Zhou, R. (2022) · Biochemical Engineering Journal · doi:10.1016/j.bej.2022.108435 · Cited by 7 · see citing works

The power of microalgae: Cutting-edge applications and groundbreaking innovations

McKinley, K., & Ozbay, G. (2026) · New Biotechnology · doi:10.1016/j.nbt.2026.04.003 · Cited by 6 · see citing works

Optimization of astaxanthin accumulation in a new Haematococcus lacustris (CZJ) strain from China via response surface methodology

Wang, L., Dai, Y., & Huang, X. (2023) · Journal of Applied Phycology · doi:10.1007/s10811-023-03117-6 · Cited by 6 · see citing works

Extending the green stage of Haematococcus pluvialis as a crucial precursor for efficient astaxanthin production: Optimization via Taguchi design

Samara, C., Biziouras, A., Papapanagiotou, G., & Chatzidoukas, C. (2025) · Biochemical Engineering Journal · doi:10.1016/j.bej.2025.109763 · Cited by 9 · see citing works

Lutein and Astaxanthin Supplementation Induce Competitive Inhibition of Carotenoid Deposition in Egg Yolk

Chen, X., Yan, Z., Zhang, B., Zeng, L., Chowdhury, U., Pabitra, M. H., Cao, J., Wang, Z., He, Y., Liu, H., et al. (2025) · Animals · doi:10.3390/ani15131869 · Cited by 6 · see citing works

Biorefinery approach to stimulate astaxanthin and biofuel generation in microalga Haematococcus pluvialis under different light irradiance

Zarei, Z., & Zamani, H. (2024) · Clean Technologies and Environmental Policy · doi:10.1007/s10098-024-02803-4 · Cited by 6 · see citing works

Red light trade-off regulating the negative effects of nitrogen concentration to improve lipid and astaxanthin production in the filamentous green microalga Oedocladium carolinianum

Zhang, H., Tan, Y., Zhu, R., Hong, J., Yu, B., Gao, B., & Zhang, C. (2024) · Algal Research · doi:10.1016/j.algal.2024.103510 · Cited by 6 · see citing works

Flow cytometry and metabolomics revealed different inorganic phosphorus response mechanisms of Chlorella pyrenoidosa

Ding, Y., Xing, Y., Xing, D., Jin, C., Zhao, Y., & Guo, L. (2024) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2024.105897 · Cited by 6 · see citing works

In vitro effects of astaxanthin on bacterial and cell viability, cell migration and mitochondrial activities in four fish cell lines

Mayor, J. A., Cuesta, A., Espinosa‐Ruíz, C., & Esteban, M. Á. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101636 · Cited by 6 · see citing works

Effect of reduced atmospheric pressures on the morphology and astaxanthin biosynthesis of microalga Haematococcus lacustris

Kim, S., Mahadi, R., Narasimhan, A. L., Christabel, C., Yu, H., Kim, E.-J., & Oh, Y. (2024) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-024-00145-y · Cited by 5 · see citing works

Single-Pulse Response LA-ICP-MS Imaging with Quadrupole Instrumentation: Theoretical Considerations and Practical Assessment

Willner, J., Brunnbauer, L., Podsednik, M., Gibbs, D. K., Kriechbaum, R., Oliver Spadiut, A., & Limbeck, A. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c01870 · Cited by 5 · see citing works

Melatonin enhances astaxanthin accumulation and photosynthesis performance of Haematococcus pluvialis

Jin, C., Sun, H., Zhou, Z., Liu, Q., & Zhou, X. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105519 · Cited by 5 · see citing works

Antioxidant and Anti‐Pollution Effect of Naturally Occurring Carotenoids Astaxanthin and Crocin for Human Skin Protection

Ácsová, A., Hojerová, J., Hergesell, K., Hideg, É., Csepregi, K., Bauerová, K., Pružinská, K., & Martiniaková, S. (2022) · ChemistrySelect · doi:10.1002/slct.202201595 · Cited by 5 · see citing works

Waste to Wealth: Phycoremediation of Saline Wastewater From the Food Processing Industry Using Dunaliella salina to Produce Beta‐Carotene in High Rate Algal Ponds

Elangovan, B., Detchanamurthy, S., Raja, V. K., & Vijayakumar, S. D. (2025) · Environmental Quality Management · doi:10.1002/tqem.70112 · Cited by 4 · see citing works

Pre-mRNA splicing and its regulation in microalgae and cyanobacteria

Do, S., Liu, Y., Huynh, H., Liu, Y., Li, W., Chen, M., & Du, Z. (2025) · Advanced Biotechnology · doi:10.1007/s44307-025-00087-3 · Cited by 4 · see citing works

Harnessing microalgae for bioproducts: innovations in synthetic biology

Li, Z., Cheng, Y., Li, C., Wu, Q., & Xin, Y. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04727-7 · Cited by 4 · see citing works

Lipids and high-value astaxanthin produced in a cupboard by heterotrophic Chromochloris zofingiensis: Improvement of process efficiency

Çakır, Z. B., & Özkan, M. (2023) · Algal Research · doi:10.1016/j.algal.2023.103175 · Cited by 4 · see citing works

Enhanced Cell Growth and Astaxanthin Production in Haematococcus lacustris by Mechanostimulation of Seed Cysts

Christabel, C., Kim, B., Narasimhan, A. L., Vahisan, L. P. S., Ilhamsyah, D. P. A., Kim, E.-J., & Oh, Y. (2024) · Applied Sciences · doi:10.3390/app142210434 · Cited by 4 · see citing works

Insights into the antioxidant activity of carotenoid standards, microalgal, and yeast extracts via spectroscopic and electrochemical methods

Hacke, A. C. M., Litke, Q., Sestric, R., Hardy, B. P., Kuss, S., Liu, S., Levin, D. B., & Sorensen, J. L. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.146338 · Cited by 4 · see citing works

Comparative study on photosynthetic and antioxidant activities of Haematococcus pluvialis vegetative and resting cells: UVA light-induced stimulation

Hamouda, M. B., Kacem, A., Achour, L., Krichen, Y., Legrand, J., Grizeau, D., & Dupré, C. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15540 · Cited by 4 · see citing works

Advancement of Carotenogenesis of Astaxanthin from Haematococcus pluvialis: Recent Insight and Way Forward

Wilawan, B., Chan, S. S., Ling, T. C., Show, P.-L., Ng, E., Jonglertjunya, W., Phadungbut, P., & Khoo, K. S. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00768-1 · Cited by 32 · see citing works

Astaxanthin-Producing Green Microalga Haematococcus pluvialis: From Single Cell to High Value Commercial Products

Shah, M. M. R., Liang, Y., Cheng, J. J., & Daroch, M. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00531 · Cited by 940 · see citing works

Astaxanthin from Haematococcus pluvialis : processes, applications, and market

Mota, G. C. P., de Moraes, L. B. S., Oliveira, C. Y. B., Oliveira, D. W. S., de Abreu, J. L., Dantas, D. M. M., & Gálvez, A. O. (2021) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2021.1966802 · Cited by 80 · see citing works

Biotechnological strategies for enhancing astaxanthin accumulation in the microalga Haematococcus pluvialis

Liu, J., Wang, Z., Chen, H., Peng, Y., & Chen, L. (2026) · Blue Biotechnology · doi:10.1186/s44315-026-00057-x

Revealing mechanisms of algal astaxanthin production and bioengineering potential using multiomics

Jeffers, T. L., & Roth, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823304-7.00010-6 · Cited by 15 · see citing works