The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Head-to-head antisense transcription and R-loop formation promotes transcriptional activation
Open accessAbstract
Significance: The molecular mechanisms used by noncoding RNAs to regulate gene expression are largely unknown. We have discovered a previously unidentified regulatory phenomenon underlying the transcriptional activation of the intermediate filament protein vimentin. This regulation involves the participation of a previously uncharacterized head-to-head antisense transcript that forms part of a hybrid DNA:RNA structure known as the R loop. R loops have been the focus of recent research regarding their unexpected involvement in gene expression regulation. Antisense-mediated formation of the R loop supports a local chromatin environment that ensures the optimal binding of vimentin transcriptional activators. In addition, we describe how hypermethylation of the locus in a large panel of colon cancer patients is correlated with antisense silencing and, thereby, compromises its regulatory activity.
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Cites
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
Kokkinos, M. I., Wafai, R., Wong, M. K., Newgreen, D. F., Thompson, E. W., & Waltham, M. (2007) · Cells Tissues Organs · doi:10.1159/000101320 · Cited by 394
Sensitive digital quantification of DNA methylation in clinical samples
Li, M., Chen, W.-D., Papadopoulos, N., Goodman, S. N., Bjerregaard, N. C., Laurberg, S., Levin, B., Juhl, H., Arber, N., Moinova, H., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1559 · Cited by 341
Cited by
Gene regulation by long non-coding RNAs and its biological functions
Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00315-9 · Cited by 4,991
R-Loops as Cellular Regulators and Genomic Threats
Crossley, M. P., Bocek, M., & Cimprich, K. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.024 · Cited by 746
Cristini, A., Groh, M., Kristiansen, M. S., & Gromak, N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.025 · Cited by 423
Oncological role of HMGA2 (Review)
Zhang, S., Mo, Q., & Wang, X. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4856 · Cited by 137
Chromatin dependencies in cancer and inflammation
Marazzi, I., Greenbaum, B. D., Low, D. H. P., & Guccione, E. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.113 · Cited by 80
Metadata
- Authors
- Boque-Sastre, R., Soler, M., Oliveira-Mateos, C., Portela, A., Moutinho, C., Sayols, S., Villanueva, A., Esteller, M., & Guil, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-04-22
- Volume
- 112
- Issue
- 18
- Pages
- 5785-5790
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2087587381
- Cited by
- 240
- References
- 3
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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