The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
R-Loops as Cellular Regulators and Genomic Threats
Open accessAbstract
Summary During transcription, the nascent RNA strand can base pair with its template DNA, displacing the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are common across many domains of life and cause DNA damage in certain contexts. In this review, we summarize recent results implicating R-loops as important regulators of cellular processes such as transcription termination, gene regulation and DNA repair. We also highlight recent work suggesting that R-loops can be problematic to cells as blocks to efficient transcription and replication that trigger the DNA damage response. Finally, we discuss how R-loops may contribute to cancer, neurodegeneration and inflammatory diseases, and compare the available next-generation sequencing-based approaches to map R-loops genome-wide.
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Cites
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Baluapuri, A., Wolf, E., & Eilers, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0215-2 · Cited by 310
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Khristich, A. N., & Mirkin, S. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007678 · Cited by 289
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Chen, H., Yang, H., Zhu, X., Yadav, T., Ouyang, J., Truesdell, S. S., Tan, J., Wang, Y., Duan, M., Wei, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16722-7 · Cited by 179
The Integrator complex cleaves nascent mRNAs to attenuate transcription
Tatomer, D. C., Elrod, N. D., Liang, D., Xiao, M.-S., Jiang, J. Z., Jonathan, M., Huang, K.-L., Wagner, E. J., Cherry, S., & Wilusz, J. E. (2019) · Genes & Development · doi:10.1101/gad.330167.119 · Cited by 167
Metadata
- Authors
- Crossley, M. P., Bocek, M., & Cimprich, K. A.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 73
- Issue
- 3
- Pages
- 398-411
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2913346540
- Cited by
- 746
- References
- 103
- FWCI
- 25.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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