The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Real-time monitoring of quorum sensing in 3D-printed bacterial aggregates using scanning electrochemical microscopy
Open accessAbstract
Significance: Bacteria commonly reside in vivo as communities comprised of small, densely packed aggregates. Aggregates display important phenotypes, including enhanced antibiotic resistance, and recent evidence suggests that chemical interactions between aggregates are critical in human-associated microbial communities. However, studying aggregates is challenging because of the inability to confine and spatially organize small microbial populations. Here, we interface two analytical technologies, micro-3D printing and scanning electrochemical microscopy, to develop an in vitro platform with the capacity to manipulate the size and spatial arrangement of bacterial aggregates and quantify chemical interactions between aggregates in real time. We show that a quorum-sensing metabolite is produced by Pseudomonas aeruginosa aggregates containing as few as 500 cells and determine how spatial structure impacts communication between neighboring aggregates.
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Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology
Hogan, D. A., Vik, Å., & Kolter, R. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04349.x · Cited by 575
Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection
Korgaonkar, A., Trivedi, U., Rumbaugh, K. P., & Whiteley, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214550110 · Cited by 315
Self-citationMetabolite Cross-Feeding Enhances Virulence in a Model Polymicrobial Infection
Ramsey, M. M., Rumbaugh, K. P., & Whiteley, M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002012 · Cited by 238
Self-citationBacterial fight-and-flight responses enhance virulence in a polymicrobial infection
Stacy, A., Everett, J., Jorth, P., Trivedi, U., Rumbaugh, K. P., & Whiteley, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400586111 · Cited by 192
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Cited by
Progress in and promise of bacterial quorum sensing research
Whiteley, M., Diggle, S. P., & Greenberg, E. P. (2017) · Nature · doi:10.1038/nature24624 · Cited by 1,285
Self-citationBacterial Communities: Interactions to Scale
Stubbendieck, R. M., Vargas-Bautista, C., & Straight, P. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01234 · Cited by 572
3D printing of bacteria into functional complex materials
Schaffner, M., Rühs, P. A., Coulter, F., Kilcher, S., & Studart, A. R. (2017) · Science Advances · doi:10.1126/sciadv.aao6804 · Cited by 425
Bodelón, G., Montes-García, V., López-Puente, V., Hill, E. H., Hamon, C., Sanz-Ortiz, M. N., Rodal-Cedeira, S., Costas, C., Celiksoy, S., Pérez-Juste, I., et al. (2016) · Nature Materials · doi:10.1038/nmat4720 · Cited by 359
The biogeography of polymicrobial infection
Stacy, A., McNally, L., Darch, S. E., Brown, S. P., & Whiteley, M. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.8 · Cited by 294
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Metadata
- Authors
- Connell, J. L., Kim, J., Shear, J. B., Bard, A. J., & Whiteley, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-12-08
- Volume
- 111
- Issue
- 51
- Pages
- 18255-18260
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2021063995
- Cited by
- 179
- References
- 5
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Connell, J. L., Kim, J., Shear, J. B., Bard, A. J., & Whiteley, M. (2014). Real-time monitoring of quorum sensing in 3D-printed bacterial aggregates using scanning electrochemical microscopy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1421211111
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
