A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology

Hogan, Deborah A.; Vik, Åshild; Kolter, Roberto

doi:10.1111/j.1365-2958.2004.04349.x

Cited by 575Bacterial biofilms and quorum sensingAntifungal resistance and susceptibilityFungal and yeast genetics research

A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology

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Hogan, Deborah A., Vik, Åshild, Kolter, Roberto·2004·Molecular Microbiology

DOI 10.1111/j.1365-2958.2004.04349.x

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Abstract

Summary: Candida albicans is an opportunistic pathogen that is commonly found as a member of the human microflora. The ability of C. albicans to alter its cellular morphology has been associated with its virulence; yeast cells are more prevalent in commensal interactions whereas filamentous cells appear important in opportunistic infections. C. albicans encounters a multitude of other microbial species in the host environment and it is likely that they impact the C. albicans transition between virulent and non‐virulent states. Here, we report that C. albicans morphology is significantly affected by the presence of Pseudomonas aeruginosa , another opportunistic pathogen. In a screen using a C. albicans HWP1–lacZ strain to indicate regions of filamentous growth, we identified P. aeruginosa mutants incapable of inhibiting C. albicans filamentation. Through these studies, we found that 3‐oxo‐C12 homoserine lactone, a cell–cell signalling molecule produced by P. aeruginosa , was sufficient to inhibit C. albicans filamentation without affecting fungal growth rates. Both microscopic analysis and real‐time reverse transcription polymerase chain reaction analysis of morphology‐specific markers confirmed that filamentation was suppressed by 200 µM 3‐oxo‐C12 homoserine lactone. Structurally related compounds with a 12‐carbon chain length, e.g. C12‐acyl homoserine lactone and dodecanol also affected C. albicans filamentation at similar concentrations. In contrast, other acylated homoserine lactones of different chain lengths did not affect fungal morphology. The activity of 3OC12HSL is compared with that of farnesol, a C. albicans ‐produced molecule also with a C12‐backbone. The effects that bacteria have on the morphology of C. albicans represents one of the ways by which bacteria can influence the behaviour of fungal cells.

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Pseudomonas aeruginosa secretes a 12-carbon acyl homoserine lactone that modulates hyphal growth by Candida albicans.
“For example, P. aeruginosa secretes a 12-carbon acyl homoserine lactone that modulates hyphal growth by C. albicans (78).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [78]
Candida albicans interacts with several bacterial species found in the gut, such as Enterococcus and Escherichia species; those found in the vagina, such as Lactobacillus species; and those found in the lungs of patients with cystic fibrosis, such as Pseudomonas aeruginosa.
“C. albicans also interacts with several bacterial species found in the gut, such as Enterococcus and Escherichia species; those found in the vagina, such as Lactobacillus species; and those found in the lungs of patients with cystic fibrosis, such as Pseudomonas aeruginosa (13, 34, 54, 78).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [78]

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Authors: Hogan, D. A., Vik, Å., & Kolter, R.
Affiliations: Dartmouth College (US)
Harvard University (US)
Corresponding author: Kolter, Roberto
ORCID: Hogan, Deborah A.
Kolter, Roberto
Venue: Molecular Microbiology
Publisher: Wiley
Published: 2004-10-15
Volume: 54
Issue: 5
Pages: 1212-1223
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1111/j.1365-2958.2004.04349.x
OpenAlex: W1776282777
Cited by: 575
References: 54
Citations by year: 2026: 18 · 2025: 6 · 2024: 11 · 2023: 29 · 2022: 20 · 2021: 39 · 2020: 33 · 2019: 23 · 2018: 26 · 2017: 37 · 2016: 32 · 2015: 35 · 2014: 37 · 2013: 30 · 2012: 30
FWCI: 6.39
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Norges Forskningsråd
National Institutes of Health
National Heart, Lung, and Blood Institute
National Institute of General Medical Sciences (R01GM058213, GM58213)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Candida albicans, Pseudomonas aeruginosa, quorum sensing, yeast-to-hypha transition, fungal-bacterial interactions, N-acyl homoserine lactones, farnesol, opportunistic pathogens, virulence
MeSH terms: Antifungal Agents, beta-Galactosidase, Candida albicans, Farnesol, Genes, Bacterial, Genes, Fungal, Homoserine, Dodecanol, Microscopy, Mutation, Pseudomonas aeruginosa, Recombinant Fusion Proteins, RNA, Fungal, RNA, Messenger, Transcription, Genetic, 4-Butyrolactone, Gene Expression Regulation, Fungal, Genes, Reporter, Reverse Transcriptase Polymerase Chain Reaction

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A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology

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