Caffeine acts through neuronal adenosine A 2A receptors to prevent mood and memory dysfunction triggered by chronic stress

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Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas

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Blockade of adenosine A2A receptor alleviates cognitive dysfunction after chronic exposure to intermittent hypoxia in mice

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Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease

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Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life

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Hippocampal synaptic dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis: Reversal by adenosine A2AR blockade

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Effect of single caffeine intake on neuropsychological functions in healthy volunteers: A double-blind placebo-controlled study

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Activation of the MAPK signaling pathway induces upregulation of pro-apoptotic proteins in the hippocampi of cold stressed adolescent mice

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Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation

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Ursolic acid abrogates depressive-like behavior and hippocampal pro-apoptotic imbalance induced by chronic unpredictable stress

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Caffeine is negatively associated with depression in patients aged 20 and older

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Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial

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Effect of Coffee in Lipopolysaccharide-Induced Indoleamine 2,3-Dioxygenase Activation and Depressive-like Behavior in Mice

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Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress

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Acute Low and Moderate Doses of a Caffeine-Free Polyphenol-Rich Coffeeberry Extract Improve Feelings of Alertness and Fatigue Resulting from the Performance of Fatiguing Cognitive Tasks

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l ‐α‐aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory

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Aβ1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes

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Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats

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Microglia cytoarchitecture in the brain of adenosine A 2A receptor knockout mice: Brain region and sex specificities

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Effects of Chronic Caffeine Administration on Behavioral and Molecular Adaptations to Sensory Contact Model Induced Stress in Adolescent Male Mice

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An Open Question: Is the A2A Adenosine Receptor a Novel Target for Alzheimer’s Disease Treatment?

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Adenosine A 2A receptor blockade attenuates spatial memory deficit and extent of demyelination areas in lyolecithin-induced demyelination model

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Astrocytic connexin43 in the medial prefrontal cortex regulates depressive- and anxiety-like behaviors via ATP release

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Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

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Effects of sub-chronic caffeine ingestion on memory and the hippocampal Akt, GSK-3β and ERK signaling in mice

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Pharmacological Blockade of Adenosine A2A but Not A1 Receptors Enhances Goal-Directed Valuation in Satiety-Based Instrumental Behavior

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Use of knockout mice to explore CNS effects of adenosine

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Purinergic system and suicidal behavior: exploring the link between adenosine A2A receptors and depressive/impulsive features

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Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome

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Xiaoyaosan Ameliorates Chronic Restraint Stress-Induced Depression-Like Phenotype by Suppressing A2AR Signaling in the Rat Striatum

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Aged mice receiving caffeine since adulthood show distinct patterns of anxiety-related behavior

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Genetic tagging of the adenosine A2A receptor reveals its heterogeneous expression in brain regions

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Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage

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CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity

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Impact of Coffee Intake on Measures of Wellbeing in Mice

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Knowledge and consumption of caffeinated products by university students in Beirut, Lebanon

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Adenosine A2A receptor modulates microglia-mediated synaptic pruning of the retinogeniculate pathway during postnatal development

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Atorvastatin ameliorates depressive behaviors via regulation of α7nAChR expression by PI3K/Akt-BDNF pathway in mice

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The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors

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Habitual caffeine consumption moderates the antidepressant effect of dorsomedial intermittent theta-burst transcranial magnetic stimulation

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Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice

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Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors

Madeira, D., Domingues, J., Lopes, C. R., Canas, P. M., Cunha, R. A., & Agostinho, P. M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04983-6 · Cited by 16

Longitudinal Effects of Lifetime Caffeine Consumption on Levels of Depression, Anxiety, and Stress: A Comprehensive Review

Ünsal, S., & Şanlıer, N. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00616-5 · Cited by 21

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am−/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Moreira-de-Sá, A., Gonçalves, F. Q., Lopes, J. P., Silva, H. B. L., Tomé, Â. R., Cunha, R. A., & Canas, P. M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02275-9 · Cited by 15

Rapid Eye Movement Sleep Deprivation Enhances Adenosine Receptor Activation and the CREB1/YAP1/c-Myc Axis to Alleviate Depressive-like Behaviors in Rats

Zhao, Y., Zhang, H., Zhang, Y., Fang, Z., & Xu, C. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00167 · Cited by 14

Repeated Cycles of Binge‐Like Ethanol Exposure Induces Neurobehavioral Changes During Short‐ and Long‐Term Withdrawal in Adolescent Female Rats

Queiroz, L. Y., de Oliveira, I. G., Cartágenes, S. D. C., Fernandes, L. M. P., dos Santos, S. M., Ferreira, W. A. S., Mello, F. A. R., Bittencourt, L. O., Paiva, E. B. C., Burbano, R. M. R., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7207755 · Cited by 14

Hippocampal pituitary adenylate cyclase–activating polypeptide mediates rapid antidepressant-like effects of Yueju pill

Ren, L., Zhang, H., Tao, W., Xue, W., Yin, C., Zou, Z., Guo, X., Shen, Q., Wang, W., Jiang, H., et al. (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102350 · Cited by 13

Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ1–42 to Model Early Alzheimer’s Disease

Lopes, C. R., Silva, A. C., Silva, H. B. L., Canas, P. M., Agostinho, P. M., Cunha, R. A., & Lopes, J. P. (2023) · Biomolecules · doi:10.3390/biom13081173 · Cited by 13

Handling stress impairs learning through a mechanism involving caspase-1 activation and adenosine signaling

Towers, A. E., Oelschlager, M. L., Lorenz, M. R., Gainey, S. J., McCusker, R. H., Krauklis, S. A., & Freund, G. G. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.025 · Cited by 14

Eugenia uniflora fruit extract exerts neuroprotective effect on chronic unpredictable stress‐induced behavioral and neurochemical changes

Flores, N. P., Bona, N. P., Luduvico, K. P., Cardoso, J. D. S., Soares, M. S. P., Gamaro, G. D., Spanevello, R. M., Lencina, C. L., Gazal, M., & Stefanello, F. M. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13442 · Cited by 15

Customization of Diet May Promote Exercise and Improve Mental Wellbeing in Mature Adults: The Role of Exercise as a Mediator

Begdache, L., & Patrissy, C. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11050435 · Cited by 13

Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson’s Disease

Kasabova-Angelova, A., Tzankova, D., Mitkov, J., Georgieva, M., Tzankova, V., Zlatkov, A., & Kondeva-Burdina, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180821153316 · Cited by 13

Upregulation of adenosine A2A receptor in astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficits

Launay, A., Carvalho, K., Génin, A., Gauvrit, T., Nobili, P., Gómez‐Murcia, V., Augustin, E., Burgard, A., Gambi, J., Fourmy, D., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03115-9 · Cited by 15

Advancing combination treatment with cilostazol and caffeine for Alzheimer's disease in high fat-high fructose-STZ induced model of amnesia

Gomaa, A. A., Farghaly, H. S. M., Ahmed, A. M., El‐Mokhtar, M. A., & Hemida, F. K. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174873 · Cited by 12

Association Between Serum Uric Acid Levels and Suicide Attempts in Adolescents and Young Adults with Major Depressive Disorder: A Retrospective Study

Kong, Y., Liu, C., Zhang, C., Wang, W., Li, Y., Qiu, H., Wang, G.-M., Li, D., Chen, X., Lv, Z., et al. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s368471 · Cited by 12

Caffeine: a potential mechanism for anti-obesity

Wang, M., Guo, W. Y., & Chen, J. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10022-1 · Cited by 13

Impact of Glucocorticoid‐Associated Stress‐Like Conditions on Aquaporin‐4 in Cultured Astrocytes and Its Modulation by Adenosine A 2A Receptors

Dias, L., Nabais, A. M., Borges-Martins, V. P. P., Canas, P. M., Cunha, R. A., & Agostinho, P. M. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.16299 · Cited by 12

Promises of Caffeine in Attention-Deficit/Hyperactivity Disorder: From Animal Models to Clinical Practice

França, A. P., Takahashi, R. N., Cunha, R. A., & Prediger, R. D. (2018) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2018.0016 · Cited by 13

The striatum drives the ergogenic effects of caffeine

Alves, A. C. D. B., Speck, A. E., Farias, H. R., Martins, L. M., Santos, N. D. S., Pannata, G., Tavares, A. P., de Oliveira, J., Tomé, Â. R., Cunha, R. A., et al. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09922-5 · Cited by 16

Acute caffeine differently affects risk-taking and the expression of BDNF and of adenosine and opioid receptors in rats with high or low anxiety-like behavior

Lind, S. F., Stam, F., Zelleroth, S., Meurling, E., Frick, A., & Grönbladh, A. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173573 · Cited by 12

Purinergic modulation of glutamate transmission: An expanding role in stress-linked neuropathology

Mayhew, J., Graham, B. A., Biber, K. P. H., Nilsson, M., & Walker, F. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.023 · Cited by 13

Signaling by adenosine receptors—Homeostatic or allostatic control?

Cunha, R. A. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000213 · Cited by 12

Caffeine's Neuroprotective Effect on Memory Impairment: Suppression of Adenosine A2A Receptor and Enhancement of Tyrosine Hydroxylase in Dopaminergic Neurons Under Hypobaric Hypoxia Conditions

Zhong, Z., Dong, H., Zhou, S., Lin, C., Huang, P., Li, X., Zhang, J., Xie, J., Wu, Y., & Li, P. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70134 · Cited by 11

The activity of the Striatal‐enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A2A receptor

Mallozzi, C., Pepponi, R., Visentin, S., Chiodi, V., Lombroso, P. J., Bäder, M., Popoli, P., & Domenici, M. R. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14866 · Cited by 11

Chronic Caffeine Ingestion Improves Motor Function and Increases Dendritic Length and Arborization in the Motor Cortex, Striatum, and Cerebellum

Olopade, F. E., Femi-Akinlosotu, O. M., Adekanmbi, A. J., Ighogboja, O. O., & Shokunbi, M. T. (2021) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2020.0017 · Cited by 11

Structural and functional characteristics of the hippocampus in depressive-like recipients after transplantation of in vitro caffeine-modulated immune cells

Markova, E. V., Knyazheva, M. A., Tikhonova, M. A., & Amstislavskaya, T. G. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136790 · Cited by 11

Adenosine A2A receptor availability in patients with early- and moderate-stage Parkinson’s disease

Waggan, I., Rissanen, E., Tuisku, J., Joutsa, J., Helin, S., Parkkola, R. K., Rinne, J. O., & Airas, L. M. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11342-1 · Cited by 11

Evaluation of antidepressant-like and anxiolytic-like activity of purinedione-derivatives with affinity for adenosine A2A receptors in mice

Dziubina, A., Szmyd, K., Zygmunt, M., Sapa, J., Dudek, M., Filipek, B., Drabczyńska, A., Załuski, M., Pytka, K., & Kieć‐Kononowicz, K. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.07.008 · Cited by 11

The Anti-Parkinsonian A2A Receptor Antagonist Istradefylline (KW-6002) Attenuates Behavioral Abnormalities, Neuroinflammation, and Neurodegeneration in Cerebral Ischemia: An Adenosinergic Signaling Link Between Stroke and Parkinson’s Disease

Zaki, M. G., Jakova, E., Pordeli, M., Setork, E., Taghibiglou, C., & Cayabyab, F. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125680 · Cited by 11

Involvement of serotonergic neurotransmission in the antidepressant-like effect elicited by cholecalciferol in the chronic unpredictable stress model in mice

Neis, V. B., Werle, I., Moretti, M., da Rosa, P. B., Camargo, A., Dalsenter, Y. D. O., Platt, N., Rosado, A. F., Engel, W. D., de Almeida, G. R. L., et al. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00979-6 · Cited by 10

Caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis

Othman, M. A., Fadel, R. A., Tayem, Y. I., Jaradat, A., Rashid, A., Fatima, A., Al‐Mahameed, A. E., & El‐Din, W. A. N. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03735-5 · Cited by 10

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

Machado, N. J., Simões, A. P., Silva, H. B. L., Ardais, A. P., Kaster, M. P., Garção, P., Rodrigues, D. I., Pochmann, D., Santos, A. I., Araújo, I. M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9774-9 · Cited by 60

SCNS.01. Adenosine receptors and brain diseases: neuroprotection and neurodegeneration

Cunha, R. A. (2014) · Blucher Neuroscience Proceedings · doi:10.5151/isnm-sine2

Chronic Caffeine Consumption Prevents Memory Disturbance in Different Animal Models of Memory Decline

Cunha, R. A., & Agostinho, P. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1408 · Cited by 241

Review Article Chronic Caffeine Consumption Prevents Memory Disturbance in Different Animal Models of Memory Decline

Cunha, R. A., & Agostinho, P. M. (2016)

Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress

Cunha, G. M. A., Canas, P. M., Oliveira, C. R., & Cunha, R. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.024 · Cited by 108