The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
Open accessAbstract
Significance: The EPIGEN Brazil Project is the largest Latin-American initiative to study the genomic diversity of admixed populations and its effect on phenotypes. We studied 6,487 Brazilians from three population-based cohorts with different geographic and demographic backgrounds. We identified ancestry components of these populations at a previously unmatched geographic resolution. We broadened our understanding of the African diaspora, the principal destination of which was Brazil, by revealing an African ancestry component that likely derives from the slave trade from Bantu/eastern African populations. In the context of the current debate about how the pattern of deleterious mutations varies between Africans and Europeans, we use whole-genome data to show that continental admixture is the main and complex determinant of the amount of deleterious genotypes in admixed individuals.
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Principal components analysis corrects for stratification in genome-wide association studies
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Fast model-based estimation of ancestry in unrelated individuals
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The Genetic Structure and History of Africans and African Americans
Tishkoff, S. A., Reed, F. A., Friedlaender, F. R., Ehret, C., Ranciaro, A., Froment, A., Hirbo, J. B., Awomoyi, A. A., Bodo, J.-M., Doumbo, O., et al. (2009) · Science · doi:10.1126/science.1172257 · Cited by 1,573 · cited 6×
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The genomic impact of European colonization of the Americas
Ongaro, L., Scliar, M. O., Flores, R., Raveane, A., Marnetto, D., Sarno, S., Gnecchi-Ruscone, G. A., Alarcón-Riquelme, M. E., Patin, E., Wangkumhang, P., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.076 · Cited by 114
Self-citationThe Genetic Diversity of the Americas
Adhikari, K., Chacón-Duque, J. C., Mendoza-Revilla, J., Fuentes-Guajardo, M., & Ruiz-Linares, A. (2017) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083115-022331 · Cited by 100
Immune senescence and biomarkers profile of Bambuí aged population-based cohort
Torres, K. C. L., Rezende, V. B. D., Lima-Silva, M. L., Santos, L. J. D. S., Costa, C. G., Mambrini, J. V. D. M., Peixoto, S. V., Tarazona-Santos, E., Martins Filho, O. A., Lima-Costa, M. F., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.006 · Cited by 30
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Metadata
- Authors
- Kehdy, F. S. G., Gouveia, M. H., Machado, M., Magalhães, W. C. S., Horimoto, A. R., Horta, B. L., Moreira, R. G., Leal, T. P., Scliar, M. O., Soares-Souza, G. B., Rodrigues-Soares, F., Araújo, G. S., Zamudio, R., Sant Anna, H. P., Santos, H. C., Duarte, N. E., Fiaccone, R. L., Figueiredo, C. A., Silva, T. M., Costa, G. N. O., Beleza, S., Berg, D. E., Cabrera, L., Debortoli, G., Duarte, D., Ghirotto, S., Gilman, R. H., Gonçalves, V. F., Marrero, A. R., Muniz, Y. C., Weissensteiner, H., Yeager, M., Rodrigues, L. C., Barreto, M. L., Lima-Costa, M. F., Pereira, A. C., Rodrigues, M. R., Tarazona-Santos, E., The Brazilian EPIGEN Project Consortium, Alcantara-Neves, N., Araújo, N. M., Carvalho, M. L. B., Conceição, J. S., Firmo, J. O. A., Gigante, D. P., Meira, L., Muniz-Queiroz, T., Oliveira, G. C., Oliveira, I. O., Peixoto, S. V., Proietti, F. A., Rodrigues, D. C., Santolalla, M. L., Strina, A., & Zolini, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-29
- Volume
- 112
- Issue
- 28
- Pages
- 8696-8701
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1800595138
- Cited by
- 274
- References
- 38
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kehdy, F. S. G., Gouveia, M. H., Machado, M., Magalhães, W. C. S., Horimoto, A. R., Horta, B. L., Moreira, R. G., Leal, T. P., Scliar, M. O., Soares-Souza, G. B., Rodrigues-Soares, F., Araújo, G. S., Zamudio, R., Sant Anna, H. P., Santos, H. C., Duarte, N. E., Fiaccone, R. L., Figueiredo, C. A., Silva, T. M., . . . Zolini, C. (2015). Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1504447112
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