The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Helical antimicrobial polypeptides with radial amphiphilicity
Open accessAbstract
Significance: We developed antimicrobial polypeptides (AMPs) with unprecedented radial amphiphilicity. Unlike typical AMPs characterized by facial amphiphilicity or biomimetic antimicrobial polymers with randomly distributed charged and hydrophobic groups, this class of AMPs is made up of homo-polypeptides that feature a radially amphiphilic (RA) structure and adopt a stable α-helical conformation with a hydrophobic helical core and a charged exterior shell, which is formed by flexible hydrophobic side chains with terminal charge group. The RA polypeptides appear to offer several advantages over conventional AMPs with regard to stability against proteases and simplicity of design. They also exhibit high antibacterial activity against both gram-negative and gram-positive bacteria and low hemolytic activity. This design may become a general platform for developing AMPs to treat drug-resistant bacteria.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
VMD: visual molecular dynamics
Humphrey, W., Dalke, A., & Schulten, K. (1996) · Journal of Molecular Graphics · doi:10.1016/0263-7855(96)00018-5 · Cited by 66,952
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Determination of minimum inhibitory concentrations
Andrews, J. M. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.suppl_1.5 · Cited by 4,129
Mansbach, R. A., & Ferguson, A. L. (2015) · The Journal of Chemical Physics · doi:10.1063/1.4914144 · Cited by 39
Self-citation
Cited by
Gan, B. H., Gaynord, J., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 511
Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens
Ding, X., Duan, S., Ding, X., Liu, R., & Xu, F. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201802140 · Cited by 489
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
Jiang, Y., Chen, Y., Song, Z., Tan, Z., & Cheng, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.016 · Cited by 267
Self-citation
Metadata
- Authors
- Xiong, M., Lee, M. W., Mansbach, R. A., Song, Z., Bao, Y., Peek, R. M., Yao, C., Chen, L.-F., Ferguson, A. L., Wong, G. C. L., & Cheng, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-10-12
- Volume
- 112
- Issue
- 43
- Pages
- 13155-13160
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2113705643
- Cited by
- 227
- References
- 5
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Helical antimicrobial polypeptides with radial amphiphilicity. https://app.cochat.ai/papers/10.1073/pnas.1507893112
- The paper
- Xiong, M., Lee, M. W., Mansbach, R. A., Song, Z., Bao, Y., Peek, R. M., Yao, C., Chen, L.-F., Ferguson, A. L., Wong, G. C. L., & Cheng, J. (2015). Helical antimicrobial polypeptides with radial amphiphilicity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1507893112
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
