The DOI matches its Crossref record; 193 of the 193 references it cites were found in a registry or an index.
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
Open accessAbstract
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have sounded a piercing alarm for the need of new effective antimicrobial agents to guard public health. Among different types of candidates, antimicrobial peptides (AMPs) and the synthetic mimics of AMPs (SMAMPs) have attracted significant enthusiasm in the past thirty years, due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. The extensive research has brought many drug candidates into clinical and pre-clinical development. Despite tremendous progresses have been made, several major challenges inherent to current design strategies have slowed down the clinical translational development of AMPs and SMAMPs. However, these challenges also triggered many efforts to redesign and repurpose AMPs. In this review, we will first give an overview on AMPs and their synthetic mimics, and then discuss the current status of their clinical translation. Finally, the recent advances in redesign and repurposing AMPs and SMAMPs are highlighted.
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Cites
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Cited by
Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines
Xiao, W., Jiang, W., Chen, Z., Huang, Y., Mao, J., Zheng, W., Hu, Y., & Shi, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02107-5 · Cited by 449
Metadata
- Authors
- Jiang, Y., Chen, Y., Song, Z., Tan, Z., & Cheng, J.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 170
- Pages
- 261-280
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W3118540542
- Cited by
- 267
- References
- 193
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jiang, Y., Chen, Y., Song, Z., Tan, Z., & Cheng, J. (2021). Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2020.12.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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