The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling
Open accessAbstract
Significance: Cervical cancer (CxCa) is the second most frequent cancer in women and the third leading cause of cancer death in women worldwide. Our global analysis of gene expression in normal, precancerous, and cancerous cervical tissue shows increased DNA replication/repair and cell proliferation followed by substantial metabolic shifts. We observed a dramatic, progressive decrease in estrogen receptor alpha (ERα) in tumor progression, and ranking specimens by estrogen-responsive gene expression correlated remarkably with histopathology. Whereas ERα expression shuts off in tumor epithelium, stromal fibroblasts in the microenvironment retain ERα, and the data indicate estrogen-related alteration of several candidate stroma–tumor signaling pathways. Our findings strongly support a role of stromal estrogen signaling in CxCa development with implications for CxCa management and control.
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Cited by
Integrated genomic and molecular characterization of cervical cancer
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Carcinogenic human papillomavirus infection
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Self-citationHigh-Risk Alphapapillomavirus Oncogenes Impair the Homologous Recombination Pathway
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Metadata
- Authors
- den Boon, J. A., Pyeon, D., Wang, S. S., Horswill, M., Schiffman, M., Sherman, M., Zuna, R. E., Wang, Z., Hewitt, S. M., Pearson, R., Schott, M., Chung, L., He, Q., Lambert, P., Walker, J., Newton, M. A., Wentzensen, N., & Ahlquist, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-08
- Volume
- 112
- Issue
- 25
- Pages
- E3255-64
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1875984885
- Cited by
- 291
- References
- 81
- FWCI
- 16.74
- Type
- journal article
- Language
- en
- Open access
- green
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- den Boon, J. A., Pyeon, D., Wang, S. S., Horswill, M., Schiffman, M., Sherman, M., Zuna, R. E., Wang, Z., Hewitt, S. M., Pearson, R., Schott, M., Chung, L., He, Q., Lambert, P., Walker, J., Newton, M. A., Wentzensen, N., & Ahlquist, P. (2015). Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1509322112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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