The DOI matches its Crossref record; 80 of the 81 references it cites were found in a registry or an index.
Circadian misalignment increases cardiovascular disease risk factors in humans
Open accessAbstract
Significance: Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease, even after controlling for traditional risk factors. Shift workers frequently undergo circadian misalignment (i.e., misalignment between the endogenous circadian system and 24-h environmental/behavioral cycles). This misalignment has been proposed to explain, in part, why shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. However, the impact of circadian misalignment per se on 24-h blood pressure and inflammatory markers is poorly understood. We show—under highly controlled laboratory conditions—that short-term circadian misalignment increases 24-h blood pressure and inflammatory markers in healthy adults. Our findings may help explain why shift work increases hypertension, inflammation, and cardiovascular disease risk.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A recent laboratory study of shift workers revealed that circadian misalignment increased 24-hour BP and CV inflammatory markers including IL-6, C-reactive protein, and TNF-α (142).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [142]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
(2007) · Cited by 6,530
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,796
Research works printed but not linked: 1
- ; Bureau of Labor Statistics US Workers on Flexible and Shift Schedules in May 2004 (US Department of Labor, Washington, DC, 2005).
Cited by
Sorted by citations
Items 601–690 of 690
Ying, Z., Ping, L., Jianwei, L., Rui, S., Yinglan, W. U., Qiwen, X. U., Xinyue, W., Yao, Z., Xu, X., Liu, Z., et al. (2024) · PubMed Central · doi:10.19852/j.cnki.jtcm.20240308.003
Os impactos da crononutrição e da alimentação no ciclo menstrual
de Souza, C. F. V., Ibrahim, M. B. J., & de Almeida, S. G. (2024) · Research Society and Development · doi:10.33448/rsd-v13i5.45799
Cronofarmacología en enfermedades neurológicas
Carbó, A. V. (2024) · Kranion · doi:10.24875/kranion.m24000075
“…turnos o guardias) son un claro factor de riesgo vascular al in-crementar el colesterol vinculado a lipoproteínas de baja densidad, la tensión arterial y la resistencia a la insulina, lo que conlleva que las personas que sufren estos ritmos caóticos padezcan más ictus que la población general 72 .”
Bedeutung des circadianen Rhythmus für organisch bedingte Erkrankungen
Wiater, A. H. (2024) · Elsevier eBooks · doi:10.1016/b978-3-437-21054-9.00006-9
Gao, L., Shi, Q., Zhang, X., Bu, X., Zheng, P., Zhou, L., Yan, J., Li, H., & Tian, G. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1415467
Quan, Y., Wang, Z., Zhang, T., Sui, Y., Zhang, X., Ji, X., Liu, A., & Jiang, W. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2024.1501316
Nelson, R. J. (2025) · Oxford University Press eBooks · doi:10.1093/9780197639979.003.0007
Smolensky, M. H., Hermida, R. C., Sackett-Lundeen, L. L., Hermida‐Ayala, R. G., & Geng, Y. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00245.x
The Influence of Environmental Factors on Cardiovascular Disease Risk: A Comprehensive Review
Ilyas, A., Batool, K., & Javed, H. (2025) · Premier Journal of Cardiology · doi:10.70389/pjc.100001 · Cited by 1
Skarke, C., Yang, W., Sha, D., Lahens, N. F., Isakova, T., Unruh, M. L., tDeo, R., Carmona-Powell, E., Holmes, J. H., Ficarra, E., et al. (2025) · medRxiv · doi:10.1101/2025.04.30.25326177
“…rhythms in healthy volunteers in a nightshift model increased blood pressure and inflammatory markers while suppressing heart rate variability (Morris et al. 2016) and blunted rhythmic gene expression profiles relevant for cellular immune response, apoptosis, cell proliferation and…”
The cellular mammalian clock regulates Staphylococcus aureus invasion in epithelial cellsPreprint
Agarwal, P., Chandrasekharan, G., Nayek, S., Grewal, J., Dallmann, R., & Unnikrishnan, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.05.652254
Qu, X. R., Cheng, Z., Li, Y. M., Han, T., & Zhang, X. L. (2025) · Scientific Reports · doi:10.1038/s41598-025-00385-9
“Habitual short sleep can also disrupt circadian rhythmicity and lead to circadian misalignment 30 .”
Guo, H., Li, H.-L., Xiao, F., Wang, H., & Xie, B.-Y. (2025) · Research Square · doi:10.21203/rs.3.rs-6338495/v1
Sleep and Circadian Development in Adults and Older Adults
Duffy, J. F., Arrona‐Palacios, A., & Song, P. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197602751.013.1
Epidemiology of Sleep and Circadian Health
Xiao, Q., & Stone, K. L. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197602751.013.12
Exposure to Artificial Light at Night Alters Ultradian Rhythms in Endothelial Function
Walton, J. C., Meléndez‐Fernández, O. H., DeVries, A. C., Chantler, P. D., & Nelson, R. J. (2025) · Journal of Vascular Research · doi:10.1159/000547915
“Both sympathetic and parasympathetic autonomic vascular responses vary across the day [34–36], and ALAN affects the balance of these responses on cardiovascular systems [37, 38].”
Ren, L. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07247-8
“Circadian rhythm disorders are closely related to elevated inflammatory markers and increased 24-hour IL-6 levels by 15% [48].”
A Timely Call to Understand the Link Between Obstructive Sleep Apnoea and Circadian Disruption
Targa, A., Sánchez‐de‐la‐Torre, M., & Barbé, F. (2025) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2025.10.016
Ruan, W., Cai, C., Matenchuk, B. A., Osachoff, L., Khurana, R., & Davenport, M. H. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00834.2025
Neuroendocrine timekeepers: changes in normal and premature aging
Petrică, M., Ferreira‐Marques, M., Ribeiro, R. F. N., & Cavadas, C. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.11.002
Additional file 1 of Harm of circadian misalignment to the hearts of the adolescent wistar rats
Wang, Y., Hou, Y., Song, S., Zuo, Y., Yu, Y., Chi, Y., & Zhang, T. (2022) · Figshare · doi:10.6084/m9.figshare.20445430
Ho, L.-J., Sheu, W. H., Lo, S.-H., Yeh, Y.-P., Hwu, C.-M., Huang, C.-N., Hsieh, C.-H., & Kuo, F.-C. (2023) · Figshare · doi:10.6084/m9.figshare.22626325
Patterson, P. D., Weiss, L. S., Weaver, M. D., Salcido, D. D., Opitz, S. E., Okerman, T. S., Smida, T. T., Martin, S. E., Guyette, F. X., Martin‐Gill, C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14227940
Patterson, P. D., Weiss, L. S., Weaver, M. D., Salcido, D. D., Opitz, S. E., Okerman, T. S., Smida, T. T., Martin, S. E., Guyette, F. X., Martin‐Gill, C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14227943
Huang, H., Liu, Z., Xie, J., & Xu, C. (2023) · Figshare · doi:10.6084/m9.figshare.23621242
Additional file 2 of Harm of circadian misalignment to the hearts of the adolescent wistar rats
Wang, Y., Hou, Y., Song, S., Zuo, Y., Yu, Y., Chi, Y., & Zhang, T. (2022) · Figshare · doi:10.6084/m9.figshare.20445433
Ma, J., Ma, N., Zhang, L., Xu, L., Liu, X., & Meng, G. (2024) · Figshare · doi:10.6084/m9.figshare.26103813
Additional file 3 of Harm of circadian misalignment to the hearts of the adolescent wistar rats
Wang, Y., Hou, Y., Song, S., Zuo, Y., Yu, Y., Chi, Y., & Zhang, T. (2022) · Figshare · doi:10.6084/m9.figshare.20445436
Ma, J., Ma, N., Zhang, L., Xu, L., Liu, X., & Meng, G. (2024) · Figshare · doi:10.6084/m9.figshare.26738640
Ma, J., Ma, N., Zhang, L., Xu, L., Liu, X., & Meng, G. (2024) · Figshare · doi:10.6084/m9.figshare.26738643
Ma, J., Ma, N., Zhang, L., Xu, L., Liu, X., & Meng, G. (2024) · Figshare · doi:10.6084/m9.figshare.26103953
Nogueira, M. G., Umemura, G. S., Vallim, J. R. D. S., Lopes, L. D. C., Almeida, V. D., & Forner‐Cordero, A. (2026) · Chronobiology International · doi:10.1080/07420528.2025.2606255
“This association of circadian misalignment and poor sleep quality has been linked to an increased risk of cardiovascular diseases (Morris et al. 2016), obesity (Chaput et al. 2023) and poor cognitive performance (Chellappa et al. 2018) and, more recently, to a decrease in motor performance (Umemura…”
Campbell, D. B., Reed, T., Slebe, R., Raina, P. S., Rutters, F., Joshi, D., de Mutsert, R., Després, J., Joris Hoeks, J., Blondin, D. P., et al. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1699140
Spatiotemporal Distributions and Forecasts of Working-Age Stroke Across 953 Locations, 1980 to 2040
Zuo, Y., Jin, W., Pi, Y., Deng, Z., Wang, J., Xie, D., Tang, Y., Xiao, S., Lin, Q., & Tang, Y. (2026) · Stroke · doi:10.1161/strokeaha.125.053122
Association of bedtime with co-morbid hypertension in OSA: a community-based study
Zhou, R., Shan, G., Hu, Y., Feng, T., Lao, M., Zhang, R., Wu, S., Chen, J., & Ou, Q. (2026) · Sleep And Breathing · doi:10.1007/s11325-026-03579-1
“In contrast, late bedtimes may contribute through circadian misalignment (e.g., delayed melatonin onset relative to clock time), shorter sleep duration, or greater evening sympathetic activation [22, 23].”
Zhang, Y., Zhu, P., Gao, D., Ji, M., Pan, Y., Dai, Y., Liu, Y., Zheng, F., & Xie, W. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.046469 · Cited by 1
“…dysfunction, which are 2 critical mechanisms involved in airway remodeling in COPD and the development of atherosclerosis in CHD. 35,47,48,52,53 Thus, improving sleep health might represent a modifiable target to mitigate inflammation-mediated pathways underlying cardiopulmonary…”
McCarthy, M. S., Colburn, Z. T., Gillette, L. H., Hodge, N. S., Hung, L.-H., Fukuda, B. N., Rhee, D., Sakai, J. H. M., & Yeung, K. Y. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1714752
“…shift work, and lengthy periods of night shift in particular, lead to circadian misalignment resulting in disruptions in neuroendocrine and immune system health along with links to cancer, mood disorders, cardiovascular disease, and metabolic dysfunction (Stimpfel, 2020; Morris et al., 2016).”
Importance de la lipolyse adipocytaire dans le contrôle de l’homéostasie des monocytes
Stunault, M. I. (2020) · theses.fr (ABES) · doi:10.70675/7182b6c6zc8aaz4c67z9badz2f04195f1787
Bmal2, a circadian-related gene as candidate in obesity and diabetes
Philippe, M. (2023) · theses.fr (ABES) · doi:10.70675/0649c89czc015z4d7fz8832z596152e96dc1
Mauvieux, B., Gabel, V., Raverot, V., Clot, C., & Besnard, S. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2661312
“…outputs such as sleep – wake timing, activity, or feeding may transiently decouple from physiological markers including melatonin secretion or core body temperature, reflecting the partially autonomous nature of circadian oscillators (Wright et al. 2005; Scheer et al. 2009; Morris et al. 2016).”
Tu, H., Kang, T., Li, H., Dong, J., Cai, J., Sun, Q., Li, Y., Li, K., Zhao, S., & Li, M. (2026) · Journal of Visualized Experiments · doi:10.3791/70866
Liu, C. P., Sosnowski, D. W., Nyhuis, C. C., Rabinowitz, J. A., Eaton, W. W., Callow, D. D., Munro, C. A., Walker, K. A., Weng, N., Ferrucci, L., et al. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.11474
Sleep Irregularity, Obesity and Coronary Endothelial Dysfunction in Metabolic Disease
Chu, Y., & Tseng, C. (2026) · Cardiology and cardiovascular medicine. · doi:10.5772/intechopen.1013521
de Ocaña-Moreno, M. L. S., García-Muñoz, A. M., Timón, I., Ruiz, G. B., Sanz, M. P., Fernández, R. V., Martínez‐Cayuelas, E., Gisbert-Gustemps, L., Lugo-Marín, J., Pin-Arboledas, G., et al. (2026) · Healthcare · doi:10.3390/healthcare14101398
“This misalignment between the endogenous circadian system and environmental cycles [22] may be associated with core ASD characteristics that affect the ability to interpret social cues, thereby impacting participation in daily life activities [23].”
Xu, X., Wang, Y., Wu, J., Wang, R., Zhan, X., Liu, R., Zhang, H., & Huang, W. (2026) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2026.103502
“Shift work, particularly night shifts (OR = 1.11), is associated with circadian rhythms, suppression of nocturnal blood pressure dipping, and, in combination with sleep deprivation, may be linked to hypertension (Wang et al., 2011; Kecklund and Axelsson, 2016; Morris et al., 2016).”
InfluentialYin, L., Lee, C. W., & Wong, A. (2026) · medRxiv · doi:10.64898/2026.05.28.26354369
Autonomic nervous system: an integrative regulator in circadian rhythm of blood pressure
Yu, Z., Zhao, M., Xu, H., Sun, J., & Jin, X. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1766490
Chatterjee, R., & Sahu, S. (2026) · Biological Rhythm Research · doi:10.1080/09291016.2026.2697745
“A negative Δθ indicates phase inversion: the caloric midpoint falls after the sleep midpoint, coinciding with the biological rest phase when insulin-mediated glucose disposal, thermogenic capacity and lipid oxidation are endogenously suppressed (Scheer et al. 2009; Morris et al. 2016).”
InfluentialHnamler, L., Lalpekhlui, R., Lalrinawma, T. S. K., Lalhmingmawii, R. C., Renthlei, Z., & Trivedi, A. K. (2026) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.70113
Andreadi, A., Andreadi, S., Todaro, F., Cerilli, M., Lodeserto, P., Pinto, G., Meloni, M., Bellia, A., Coppeta, L., Magrini, A., et al. (2026) · Healthcare · doi:10.3390/healthcare14131979 · Cited by 1
“[37–39] Changes in muscle glucose uptake; effects depend on intensity, meals, hydration, medication, and diabetes status.”
Nabe‐Nielsen, K., Papantoniou, K., Arup, A. E. S. F., Sallerup, M., Nielsen, H. B., Schlünssen, V., & Garde, A. H. (2026) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-026-02218-2
“In another study of 14 healthy male and female adults, hsCRP concentration rose by 7% after one 24-hour period of circadian misalignment, but did not increase further with additional days of misalignment (up to three days) (Morris et al. 2016).”
Frenken, K. G., Scheer, F. A. J. L., Qian, J., Bours, M. J. L., Breukink, S. O., Janssen-Heijnen, M. L. G., Konsten, J., Keulen, E. T. P., Bons, J. A. P., Meijer, K., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10268142/v1
Self-citationCircadian misalignment in shift work and psychiatric outcomes: a narrative review
Selvı, Y., Ekici, F., Kaya, S., & Atılgan, M. C. (2026) · Biological Rhythm Research · doi:10.1080/09291016.2026.2704134
“Experimental human data show that circadian misalignment can exert adverse effects on metabolic and cardiovascular markers even over short time frames (Scheer et al. 2009; Morris et al. 2016).”
Role of chrononutrition in modulating metabolic and cardiovascular health
Shukla, V., Hussain, S., Fatima, G., KHAN, S. K., Hadi, N. R., Fedačko, J., & Magomedova, A. (2026) · Scripta Medica · doi:10.5937/scriptamed57-63638
“28 Therefore, chrononutrition advocates for earlier and lighter evening meals to support efficient digestion and optimal metabolic function.”
InfluentialMori, Y., Matsui, K., Shishido, R., Hino, M., Satô, A., Nagaoka, A., Hatano, M., Hosogai, Y., Miyahara, K., Miura, I., et al. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.109174
Camerzan, I. (2026) · Moldovan Journal of Health Sciences · doi:10.52645/mjhs.2026.2.09
Time-varying eating behaviors and long-term risk of incident hypertension in a Japanese cohort
Sano, A., Yamamoto, S., Okada, H., Nakajima, H., Ushigome, E., Nakanishi, N., Hamaguchi, M., Kurogi, K., Murata, H., Tsuda, E., et al. (2026) · Hypertension Research · doi:10.1038/s41440-026-02766-7
Panah, M. Y., Alidosti, M., Tavassoli, E., & Jouneghani, A. S. (2026) · Epidemiology and Health System Journal · doi:10.34172/ehsj.26590
Jeibmann, A., Qi, M., Hellmich, M., Godt, A., Kottke, T., & Goett-Zink, L. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c06484
Văcărescu, C., & Cozma, D. C. (2026) · Medicina · doi:10.3390/medicina62081513 · Cited by 2
“CGM data graphically display this temporal effect, promoting earlier dinner adoption [32].”
Super, C., Asif, M., Compher, C. W., Schurr, T. G., & Hoke, M. K. (2026) · American Journal of Human Biology · doi:10.1002/ajhb.70314 · Cited by 1
“The increased BP may have multiple causes (Morris et al. 2016).”
Wang, L., Leng, Y.-Q., Wang, W.-Z., & Sun, J. (2026) · Journal of International Medical Research · doi:10.1177/03000605261474730
“30,31 A UK Biobank analysis involving more than 400,000 participants also reported associations between shift work, poor sleep, elevated blood pressure, and systemic in fl ammation.”
Temporal misalignment of renal sodium transport promotes non-dipping blood pressure phenotypes
Layton, A. T. (2026) · PLoS ONE · doi:10.1371/journal.pone.0355222
“More broadly, the phase-misalignment simulations provide a potential mechanistic framework linking circadian disruption associated with shift work, irregular sleep schedules, and sleep disorders to non-dipping hypertension and altered nocturnal sodium handling [6,40].”
Delice, M. C., Deniz, S. S., Doğan, İ., Tureli, B., Sakar, H. A., & Öztürk, N. K. (2026) · BMC Anesthesiology · doi:10.1186/s12871-026-04180-5
“Continuous-time approaches allow temporal variation to be evaluated without imposing arbitrary cut-points and are particularly appropriate for circadian phenomena because clock time is inherently cyclic rather than linear [17, 18].”
Pollock, D. M., Martino, T. A., Knutson, K. L., Panda, S., Chaix, A., Paul, K., Shimbo, D., & Gumz, M. L. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atv.0000000000000198
Heshmati, A., & Matusiak, B. S. (2026) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2026.2701718
Zhang, Q., Zhou, B., Wang, Y., Zhang, J., Wang, Y., & Hu, K. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.109236
Self-citationMurad, I. S. (2025) · Journal of Prevention Diagnosis and Management of Human Diseases · doi:10.55529/jpdmhd.52.56.67
Circadian and behavioral timing in MASLD: a systematic review of human observational studies
Subramanian, A., Ali, R. A. R., Dawe, G. S., & Subramaniyan, V. (2026) · EClinicalMedicine · doi:10.1016/j.eclinm.2026.104187 · Cited by 1
“7,8 These mechanisms are compatible with the observed associations but do not prove liver-specific causality.”
Ye, X., Huang, C., Zhou, J., Qiu, Z., Wu, J., Wu, H., & Mo, L. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1934083
“…desynchronization and neuroendocrine rhythm disruption (e.g., impaired adaptation of melatonin and cortisol rhythms to night work) (48), but also through emerging mechanisms including chronic low-grade inflammation (75, 76), gut microbiota dysbiosis (77), and epigenetic alterations (78) (Figure 1).”
Targa, A., Benitez, I. D., Henríquez‐Beltrán, M., Parise, B. K., Giatti, S., Santos, R. B., Lotufo, P. A., Benseñor, I. M., Juez-Garcia, I., Gràcia‐Lavedan, E., et al. (2026) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2026.08.003
Chang, F., Xu, J., Guo, M., Xu, H., Li, D., Covassin, N., Somers, V. K., Wang, K., Wang, Y., & Li, J. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.048656
Chen, Y., Li, S., Tian, F., Zhu, J., Hou, P., He, X., & Sun, L. (2026) · Global Perspectives on Nutrition · doi:10.1093/gpnutr/woag014
Haskologlu, I. C., & Özünal, Z. G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198473
“In a controlled crossover study involving healthy adults, acute circadian misalignment increased blood pressure and selected inflammatory risk markers [89].”
The nutritional and metabolic impact of night shift work in a real-world setting
Jassil, F. C., Phillips, N. E., Hemmer, A., Joris, C., Biancolin, A. D., Hartmeyer, S. L., Dorribo, V., Perrig, S. H., Genton, L., Virginie Sterpenich, A., et al. (2026) · npj Biological Timing and Sleep · doi:10.1038/s44323-026-00107-y
“Circadian misalignment also led to increased blood pressure (BP) and impaired attention, the latter being associated with increased sleepiness 9,11 .”
Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework
Nasrallah, D., Abdelhamid, A. H., Tluli, O., Al-Haneedi, Y., Hussien, M. A., & Eid, A. H. (2026) · Journal of Cellular Physiology · doi:10.1002/jcp.70233
Bai, J., Chen, P., Cui, C., & Yang, L. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1917205
“Night-to-night variability in sleep timing produces recurrent misalignment between the behavioral sleep – wake cycle and the endogenous circadian clock, disrupting the temporal coordination of cortisol secretion, sympathovagal balance, and vascular reactivity (16, 32, 33).”
Bernstein, R., Bovilla, V. R., Cone, S. J., Sharma, T., Hoyo, C., & Gaddameedhi, S. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2732184
Associations between adipokines and arterial hypertension in young people
Ledovskikh, S. R. (2026) · Ateroscleroz · doi:10.52727/2078-256x-2026-22-3-366-380
The Impact of Day Shift and Night Shift Work on Vital Signs And Sleep Patterns in Healthcare Workers
Yadav, N., Raghav, D., & Bhawna, D. (2025) · PAIN JOINTS SPINE · doi:10.1922/pjs.15.4.2025.1196
Circadian misalignment and low-grade inflammation: Failure of temporal gating by the molecular clock
Lee, Y., & Lee, H.-J. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2743662
Dozzani, I., Rodríguez‐Martín, M., Dashti, H. S., Vetter, C., Fernández‐Breis, J. T., Florez, J. C., Saxena, R., Scheer, F. A. J. L., & Garaulet, M. (2026) · International Journal of Obesity · doi:10.1038/s41366-026-02225-w
Self-citationCharacterization of 24-Hour Rhythms in Vital Signs in Intensive Care Populations: A Scoping Review
Hiemstra, F. W., van Winden, L., Bos, R., van Westerloo, D. J., Dudink, J., Schoones, J. W., Ruben, M. D., & Kervezee, L. (2026) · Journal of Biological Rhythms · doi:10.1177/07487304261487544
Cortisol Dynamics at High Temporal Resolution For Wearable Biosensor Research
Ferdoushi, M., Billings, T., Cai, W., & Khan, Y. (2026) · Advanced Sensor Research · doi:10.1002/adsr.70212
“Flattened or phase-shifted cortisol rhythms are linked to impaired glucose tolerance, insulin resistance, and increased risk of type 2 diabetes and obesity, as well as heightened cardiovascular risks including hypertension and non-dipping blood pressure profiles [ 32–34 ].”
Kim, R., Evanski, J. M., Smith, T., Forger, D. B., Kaplan, C. M., Clauw, D. J., & Whibley, D. (2026) · iScience · doi:10.1016/j.isci.2026.117930
“19 However, the role of circadian physiology in the development of chronic pain remains underexplored.”
A Call to Action: Challenges and Future Directions for Sleep Health in Europe
Pilkington‐Cheney, F., André, C., Ucak, S., Messaoud, R. B., Biller, A. M., Dias, I., Prius-Mengual, J., Noaín, D., Pawley, M., Monisha, R., et al. (2026) · Journal of Sleep Research · doi:10.1111/jsr.70467
Yang, M., Qian, X., Lin, W., & Yang, R. (2026) · Metabolites · doi:10.3390/metabo16110805
Aquino-Santos, H. C., Tavares‐Vasconcelos, J. S., Silva-Reis, A., Brandão-Rangel, M. A. R., Morais‐Felix, R. T., Santa‐Rosa, F. A., Bachi, A. L. L., Soares, V., Salehian, O., Frison, C. R., et al. (2026) · Experimental Physiology · doi:10.1113/ep094113
Shift Work and Acute Coronary Syndrome: Mechanisms, Modifying Factors, and Clinical Prevention
Wang, L., Ganesan, K., Liu, X., Yu, L., & Chen, Q. (2026) · Healthcare · doi:10.3390/healthcare14213651
Metadata
- Authors
- Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-02-08
- Volume
- 113
- Issue
- 10
- Pages
- E1402-11
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4790999
- OpenAlex
- W2259214365
- Cited by
- 691
- References
- 81
- Citations by year
- 2026: 82 · 2025: 84 · 2024: 69 · 2023: 87 · 2022: 82 · 2021: 74 · 2020: 64 · 2019: 49 · 2018: 43 · 2017: 45 · 2016: 10
- FWCI
- 69.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration (NCC958)
- Brigham and Women's Hospital (UL1RR025758)
- Harvard University (UL1RR025758)
- National Space Biomedical Research Institute (P01 AG009975, NCC 9‐58)
- National Institute on Aging (R01AG048108, P01AG009975)
- National Heart, Lung, and Blood Institute (R00HL102241, R01HL118601, R01HL094806)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099512, DK099512)
- National Center for Research Resources (UL1RR025758)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- circadian misalignment, shift work, cardiovascular risk, hypertension, blood pressure, sleep blood pressure, cardiac vagal modulation, heart rate variability, urinary epinephrine, urinary norepinephrine, inflammation, interleukin-6, C-reactive protein, resistin, TNF-α
- MeSH terms
- Adult, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Circadian Rhythm, Epinephrine, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Risk Factors, Time Factors, Tumor Necrosis Factor-alpha, Work Schedule Tolerance, Interleukin-6, Polysomnography, Cross-Over Studies, Sleep Disorders, Circadian Rhythm, Resistin, Young Adult, Actigraphy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
