The DOI matches its Crossref record; 80 of the 81 references it cites were found in a registry or an index.
Circadian misalignment increases cardiovascular disease risk factors in humans
Open accessAbstract
Significance: Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease, even after controlling for traditional risk factors. Shift workers frequently undergo circadian misalignment (i.e., misalignment between the endogenous circadian system and 24-h environmental/behavioral cycles). This misalignment has been proposed to explain, in part, why shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. However, the impact of circadian misalignment per se on 24-h blood pressure and inflammatory markers is poorly understood. We show—under highly controlled laboratory conditions—that short-term circadian misalignment increases 24-h blood pressure and inflammatory markers in healthy adults. Our findings may help explain why shift work increases hypertension, inflammation, and cardiovascular disease risk.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A recent laboratory study of shift workers revealed that circadian misalignment increased 24-hour BP and CV inflammatory markers including IL-6, C-reactive protein, and TNF-α (142).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [142]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
(2007) · Cited by 6,530
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,796
Research works printed but not linked: 1
- ; Bureau of Labor Statistics US Workers on Flexible and Shift Schedules in May 2004 (US Department of Labor, Washington, DC, 2005).
Cited by
Sorted by citations
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738
“Even a short-term circadianmisalignment (12-h inverted behavioral and environmental cycles for three days) adversely affects cardiovascular risk factors in healthy adultswith increased 24-h systolic and diastolic blood pressure, and increased inflammatory markers which may explain, at least in part, why shift work inc…”
BackgroundYin, J., Jin, X., Shan, Z., Li, S., Huang, H., Li, P., Peng, X., Peng, Z., Yu, K., Bao, W., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005947 · Cited by 721
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures
Potter, G. D., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1083 · Cited by 781
“ability and insulin sensitivity in healthy adults (128, 241).”
Epigenetic regulation of aging: implications for interventions of aging and diseases
Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 732
“Notably, a short-term circadian misalignment of 12-h inverted behavioral and environmental cycles for three days increases blood pressure and inflammatory markers in humans.(341) However, how regular circadian rhythm benefits the healthspan, especially from the lens of epigenetic mechanisms, still needs further invest…”
BackgroundJamshed, H., Beyl, R., Della Manna, D., Yang, E., Ravussin, E., & Peterson, C. (2019) · Nutrients · doi:10.3390/nu11061234 · Cited by 664
The role of insufficient sleep and circadian misalignment in obesity
Chaput, J., McHill, A. W., Cox, R. C., Broussard, J. L., Dutil, C., da Costa, B. G. G., Sampasa‐Kanyinga, H., & Wright, K. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00747-7 · Cited by 733
Association between circadian rhythms and neurodegenerative diseases
Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. S. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30461-7 · Cited by 677
Self-citationThe aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 645
“…evidence that disrupted circadian rhythms are an early warning sign of developing neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s (3–5), and that the circadian clock is heavily implicated in the etiology of metabolic diseases, chronic inflammation, and cancers (6–9).”
Environmental Determinants of Cardiovascular Disease
Bhatnagar, A. (2017) · Circulation Research · doi:10.1161/circresaha.117.306458 · Cited by 636
Bile Acid Metabolism in Liver Pathobiology
Chiang, J. Y. L., & Ferrell, J. M. (2018) · Gene Expression · doi:10.3727/105221618x15156018385515 · Cited by 571
Disturbance of the Circadian System in Shift Work and Its Health Impact
Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 580
Circadian disruption and human health
Fishbein, A. B., Knutson, K. L., & Zee, P. C. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148286 · Cited by 468
“Indeed, experimental induction of circadian misalignment in humans increases blood pressure (6, 108, 149).”
BackgroundRole of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443
“A recent laboratory study of shift workers revealed that circadian misalignment increased 24-hour BP and CV inflammatory markers including IL-6, C-reactive protein, and TNF-α (142).”
Later circadian timing of food intake is associated with increased body fat
McHill, A. W., Phillips, A. J., Czeisler, C. A., Keating, L., Yee, K., Barger, L. K., Garaulet, M., Scheer, F. A., & Klerman, E. B. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.161588 · Cited by 414
Self-citationCircadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 370
“Epinephrine, an important counterregulatory hormone, displays a strong and consistent endogenous circadian oscillation in humans, with a broad peak during the middle of the biological day [96].”
BackgroundSelf-citationLifestyle interventions for the prevention and treatment of hypertension
Valenzuela, P. L., Carrera‐Bastos, P., Gálvez, B. G., Ruiz‐Hurtado, G., Ordovás, J. M., Ruilope, L. M., & Lucía, A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00437-9 · Cited by 400
Environmental risk factors and cardiovascular diseases: a comprehensive expert review
Münzel, T. F., Hahad, O., Sørensen, M., Lelieveld, J., Duerr, G. D., Nieuwenhuijsen, M. J., & Daiber, A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab316 · Cited by 404
Impact of Circadian Disruption on Cardiovascular Function and Disease
Chellappa, S. L., Vujović, N., Williams, J. S., & Scheer, F. A. J. L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.008 · Cited by 346
“Using a simulated shift work protocol, healthy non-shift workers underwent 3 days under circadian alignment (“day shift work”) or circadian misalignment (“night shift work”) [22].”
BackgroundSelf-citationExercise Metabolism and Adaptation in Skeletal Muscle
Smith, J. A. B., Murach, K. A., Dyar, K. A., & Zierath, J. R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00606-x · Cited by 342
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282
Circadian clock-mediated regulation of blood pressure
Douma, L. G., & Gumz, M. L. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.024 · Cited by 267
“This same group conducted a longer term (8 days) study in healthy humans to test the effect of circadian misalignment on markers of CVD risk [30].”
BackgroundEffect of night-time temperatures on cause and age-specific mortality in London
Murage, P., Hajat, S., & Kovats, S. R. (2017) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000005 · Cited by 252
Importance of circadian timing for aging and longevity
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 258
Soil and water pollution and human health: what should cardiologists worry about?
Münzel, T. F., Hahad, O., Daiber, A., & Landrigan, P. J. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac082 · Cited by 279
“Disruption of circadian rhythm may promote the pathogenesis of a variety of disease including cardiovascular diseases.(38,39) There is ample experimental and clinical evidence suggesting a significant link between circadian rhythms and the development or progression of cardiovascular diseases.”
The circadian clock and liver function in health and disease
Mukherji, A., Bailey, S. M., Staels, B., & Baumert, T. F. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.020 · Cited by 246
Social Jetlag and Related Risks for Human Health: A Timely Review
Caliandro, R., Streng, A. A., van Kerkhof, L. W. M., van der Horst, G. T. J., & Chaves, I. (2021) · Nutrients · doi:10.3390/nu13124543 · Cited by 231
Wang, N., Sun, Y. B., Zhang, H., Wang, B., Chen, C., Wang, Y., Chen, J., Tan, X. W., Zhang, J., Xia, F., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab505 · Cited by 228
“Moreover, recent experiments related night shift work to increased cardiovascular inflammatory markers such as interleukin-6, C-reactive protein and tumour necrosis factor a.(35,36) The degree of oxidative stress damage was higher in night workers, which may lead to an increase in inflammatory factors.”
BackgroundValidation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk
Lunsford‐Avery, J. R., Engelhard, M., Návar, A. M., & Kollins, S. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-32402-5 · Cited by 222
Kervezee, L., Kosmadopoulos, A., & Boivin, D. B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14216 · Cited by 232
Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers
Morris, C. J., Purvis, T. E., Mistretta, J., Hu, K., & Scheer, F. A. J. L. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417697537 · Cited by 209
“…protein (hs-CRP; a marker of systemic inflammation), tumor necrosis factor (TNF)-α (proinflammatory), interleukin (IL)-6 (pro- and antiinflammatory), IL-10 (anti-inflammatory) and resistin (pro-inflammatory) in non-shift workers (Leproult et al., 2014; Wright et al., 2015; Morris et al., 2016a).”
BackgroundSelf-citationWhen Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis
Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 199
Melatonin effects on glucose metabolism: time to unlock the controversy
Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. A. J. L. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.11.011 · Cited by 193
Self-citationEvaluation of Sleep Habits and Disturbances Among US Adults, 2017-2020
Di, H., Guo, Y., Daghlas, I., Wang, L., Liu, G., Pan, A., Liu, L., & Shan, Z. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.40788 · Cited by 183
Association Between Residential Greenness and Cardiovascular Disease Risk
Yeager, R. A., Riggs, D. W., DeJarnett, N. K., Tollerud, D. J., Wilson, J. S., Conklin, D. J., O’Toole, T. E., McCracken, J., Lorkiewicz, P. K., Xie, Z., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009117 · Cited by 178
“However, a spot urine collection was preferred to prevent “averaging” out of the levels of catecholamines such as epinephrine, which show large circadian variations.(54) Urine was collected during a similar time window (afternoon) for most participants, to minimize circadian variation.”
BackgroundQian, J., Dalla Man, C., Morris, C. J., Cobelli, C., & Scheer, F. A. J. L. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13391 · Cited by 170
Self-citationMisalignment with the external light environment drives metabolic and cardiac dysfunction
West, A. C., Smith, L. C., Ray, D. W., Loudon, A. S. I., Brown, T. M., & Bechtold, D. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00462-2 · Cited by 173
Grimaldi, D., Carter, J. R., Van Cauter, E., & Leproult, R. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06847 · Cited by 153
“There is, however, a discrepancy between our findings and those of Morris et al. 32 regarding BP and urinary NE responses to CM.”
InfluentialTime‐restricted feeding for prevention and treatment of cardiometabolic disorders
Melkani, G. C., & Panda, S. (2017) · The Journal of Physiology · doi:10.1113/jp273094 · Cited by 155
“Similarly, lifestyle perturbation of the circadian clock, as occurs among shift workers or in experimental models of shiftwork in animals, can disrupt the circadian clock and trigger obesity, diabetes, mitochondrial diseases and CVD (Maury et al. 2010; Gill et al. 2015; Morris et al. 2016; St-Onge et al. 2016).”
InfluentialThe role of the circadian clock system in physiology
Pilorz, V., Helfrich‐Förster, C., & Oster, H. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2103-y · Cited by 164
“dark cycle as caused by shift work or jetlag is usually characterized by feelings of fatigue, sleepiness, insomnia, digestive troubles, irritability, poorer mental agility, cardiovascular disease, and reduced general performance [2, 64, 97, 99, 114, 169].”
McAllister, M. J., Pigg, B., Rentería, L. I., & Waldman, H. S. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.12.001 · Cited by 152
“This circadian clock is often disrupted by weight gain, age, shift work, and calorie dense diets [23-26] and may be a potential cause of cardiometabolic disease [27].”
BackgroundCircadian rhythmicity of body temperature and metabolism
Refinetti, R. (2020) · Temperature · doi:10.1080/23328940.2020.1743605 · Cited by 155
“[5] Morris CJ, Purvis TE, Hu K, et al.”
BackgroundNeurodegeneration and the Circadian Clock
Hood, S., & Amir, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00170 · Cited by 152
“…circadian desynchrony is already implicated in a number of disease states, including some cancers, metabolic diseases, and mood disorders such as bipolar disease and major depression (Roybal et al., 2007; McFadden et al., 2014; Stevens et al., 2014; Lucassen et al., 2016; Morris et al., 2016).”
BackgroundVillanueva, J. E., Livelo, C., Trujillo, A. S., Chandran, S., Woodworth, B., Andrade, L., Le, H. D., Manor, U., Panda, S., & Melkani, G. C. (2019) · Nature Communications · doi:10.1038/s41467-019-10563-9 · Cited by 160
Sleep and circadian regulation of cortisol: A short review
O'Byrne, N. A., Yuen, F., Butt, W. Z., & Liu, P. Y. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.011 · Cited by 145
Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 147
Li, E., Li, X., Huang, J., Xu, C., Liang, Q., Ren, K., Bai, A., Lü, C., Qian, R., & Sun, N. (2020) · Protein & Cell · doi:10.1007/s13238-020-00713-x · Cited by 142
Off the Clock: From Circadian Disruption to Metabolic Disease
Maury, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071597 · Cited by 148
Sex differences in the circadian misalignment effects on energy regulation
Qian, J., Morris, C. J., Caputo, R., Wang, W., Garaulet, M., & Scheer, F. A. J. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914003116 · Cited by 139
Self-citationvan der Merwe, C., Münch, M. Y., & Kruger, R. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac093 · Cited by 158
Sleep and immunity in times of COVID-19
Silva, E. D. S. M. E., Ono, B. H. V. S., & Souza, J. C. (2020) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.66.s2.143 · Cited by 129
BaHammam, A. S., & Pirzada, R. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5030034 · Cited by 144
“…rhythms can compromise the functioning of these organs and impact the overall metabolic systems in the body [7] and has been correlated with adverse health outcomes, including diminished energy metabolism [8], impaired glucose metabolism [9], and heightened risk of cardiovascular disease [10].”
BackgroundGominak, S. C. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.07.007 · Cited by 130
m6A RNA Methylation in Cardiovascular Diseases
Wu, S., Zhang, S., Wu, X., & Zhou, X. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.08.010 · Cited by 125
“Recent studies have shown that many clock genes, as well as clock output gene transcripts, bear m(6)A modifications, showing that m(6)A plays a significant role in setting the pace of the circadian cycle and determining clock stability, misalignment of which is known to be a risk factor for CVDs in humans.(52,53) An e…”
BackgroundTiming of food intake: identifying contributing factors to design effective interventions
Dashti, H. S., Scheer, F. A. J. L., Saxena, R., & Garaulet, M. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy131 · Cited by 121
Self-citationCircadian Rhythms, Exercise, and Cardiovascular Health
Hower, I. M., Harper, S. A., & Buford, T. W. (2018) · Journal of Circadian Rhythms · doi:10.5334/jcr.164 · Cited by 126
“Circadian misalignment over long periods of time is associated with elevated blood pressure [9, 32], reduce sleep quality [9], and increase overall cardiovascular risk [1, 9, 23, 31, 32].”
BackgroundInfluentialDaily circadian misalignment impairs human cognitive performance task-dependently
Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-20707-4 · Cited by 128
Self-citationGhrelin is impacted by the endogenous circadian system and by circadian misalignment in humans
Qian, J., Morris, C. J., Caputo, R., Garaulet, M., & Scheer, F. A. J. L. (2019) · International Journal of Obesity · doi:10.1038/s41366-018-0208-9 · Cited by 119
Self-citationKanki, M., Nath, A. P., Xiang, R., Yiallourou, S. R., Fuller, P. J., Cole, T. J., Cánovas, R., & Young, M. J. (2023) · Nature Communications · doi:10.1038/s41467-023-42758-6 · Cited by 131
“Shift work induced circadian misalignment has also been linked to elevated serum CRP levels, BP, interleukin-6 and tumour necrosis factor-α and increased cardiovascular disease risk 61,62 .”
Circadian rhythm and disease: Relationship, new insights, and future perspectives
Neves, A. R., Albuquerque, T., Quintela, T., & Costa, D. R. B. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30815 · Cited by 128
“Recent experimental human studies provided new insights into the effect of circadian disruption on cardiovascular risk (Morris et al., 2016).”
BackgroundOSA and Cardiovascular Risk in Pediatrics
Smith, D. F., & Amin, R. S. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.02.011 · Cited by 114
A Pilot Characterization of the Human Chronobiome
Skarke, C., Lahens, N. F., Rhoades, S. D., Campbell, A. E., Bittinger, K. L., Bailey, A., Hoffmann, C., Olson, R. S., Chen, L., Yang, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17362-6 · Cited by 109
Intraindividual variability in sleep and comorbid medical and mental health conditions
Slavish, D. C., Taylor, D. J., & Lichstein, K. L. (2019) · SLEEP · doi:10.1093/sleep/zsz052 · Cited by 116
“Evidence from experimental circadian misalignment and simulated rotating night shift work studies suggests that greater variability in simulated sleep schedules is in turn associated with elevated inflammation, dysregulated cortisol, and insulin resistance [32, 76, 77].”
BackgroundIslam, Z., Hu, H., Akter, S., Kuwahara, K., Kochi, T., Eguchi, M., Kurotani, K., Nanri, A., Kabe, I., & Mizoue, T. (2019) · SLEEP · doi:10.1093/sleep/zsz204 · Cited by 116
“Human experimental studies have shown that disruption in biological sleep timing affects the circadian endocrine function and results in a decreased mean 24-hour melatonin level [38] and an altered pattern of 24-hour 0.”
BackgroundКоростовцева, Л. С., Викторович, Б. М., & Sviryaev, Y. V. (2021) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2021.05.001 · Cited by 112
Effect of Sleep Disturbances on Blood Pressure
Makarem, N., Alcántara, C., Williams, N., Bello, N. A., & Abdalla, M. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14479 · Cited by 122
Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity
Schloss, M. J., Świrski, F. K., & Nahrendorf, M. (2020) · Circulation Research · doi:10.1161/circresaha.120.315936 · Cited by 114
Calcineurin signaling in the heart: The importance of time and place
Parra, V., & Rothermel, B. A. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.12.006 · Cited by 109
At the Interface of Lifestyle, Behavior, and Circadian Rhythms: Metabolic Implications
Bae, S.-A., Fang, M., Rustgi, V. K., Zarbl, H., & Androulakis, I. P. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00132 · Cited by 103
Chronobiological Influence Over Cardiovascular Function
Rana, S., Prabhu, S. D., & Young, M. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.313349 · Cited by 99
Gumz, M. L., Shimbo, D., Abdalla, M., Balijepalli, R. C., Benedict, C., Chen, Y., Earnest, D. J., Gamble, K. L., Garrison, S., Gong, M. C., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19372 · Cited by 105
Circadian misalignment increases mood vulnerability in simulated shift work
Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-75245-9 · Cited by 106
Self-citationAltered mitochondrial metabolism in the insulin‐resistant heart
Makrecka‐Kuka, M., Liepinsh, E., Murray, A. J., Lemieux, H., Dambrova, M., Tepp, K., Puurand, M., Käämbre, T., Han, W. H., de Goede, P., et al. (2019) · Acta Physiologica · doi:10.1111/apha.13430 · Cited by 93
Nikbakhtian, S., Reed, A. B., Obika, B. D., Morelli, D., Cunningham, A. C., Aral, M., & Plans, D. (2021) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztab088 · Cited by 94
Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock
Kemler, D., Wolff, C. A., & Esser, K. A. (2020) · The Journal of Physiology · doi:10.1113/jp279779 · Cited by 87
“This finding could be of interest as exercise has the potential to work as therapeutic to battle negative health outcomes linked to a lifestyle promoting circadian disruption as seen in e.g. shift workers (Jørgensen et al., 2017; Koshy et al., 2019; Morris et al., 2016; Zimmet et al., 2019).”
Lo, E. H., Albers, G. W., Dichgans, M., Donnan, G. A., Esposito, E., Foster, R., Howells, D. W., Huang, Y.-G., Ji, X., Klerman, E. B., et al. (2021) · Stroke · doi:10.1161/strokeaha.120.031742 · Cited by 92
Self-citationThe Effects of Shift Work on Cardio-Metabolic Diseases and Eating Patterns
Hemmer, A., Mareschal, J., Dibner, C., Pralong, J. A., Dorribo, V., Perrig, S. H., Genton, L., Pichard, C., & Collet, T. (2021) · Nutrients · doi:10.3390/nu13114178 · Cited by 96
Debono, M., Harrison, R. F., Chadarevian, R., Gueroult, C., Abitbol, J.-L., & Newell-Price, J. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00823 · Cited by 100
“Circadian misalignment, as seen in shift workers, is associated with higher cortisol levels in the evening and higher 24-hour IL-6 levels (22, 23).”
BackgroundHealth position paper and redox perspectives - Disease burden by transportation noise
Sørensen, M., Pershagen, G., Thacher, J. D., Lanki, T., Wicki, B., Röösli, M., Vienneau, D., Cantuaria, M. L., Schmidt, J. H., Aasvang, G. M., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102995 · Cited by 95
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine
Pourcet, B., & Duez, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01630 · Cited by 88
Nuclear Receptors in the Control of the NLRP3 Inflammasome Pathway
Duez, H., & Pourcet, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.630536 · Cited by 85
Modified Cortisol Circadian Rhythm: The Hidden Toll of Night-Shift Work
Andreadi, A., Andreadi, S., Todaro, F., Ippoliti, L., Bellia, A., Magrini, A., Chrousos, G. P., & Lauro, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052090 · Cited by 102
“This misalignment affects multiple physiological processes, including metabolism, immune function, and cardiovascular regulation, increasing the risk of metabolic syndrome, obesity, and type 2 diabetes [11,19].”
A circadian based inflammatory response – implications for respiratory disease and treatment
Comas, M., Gordon, C. J., Oliver, B. G. G., Stow, N. W., King, G. G., Sharma, P. K., Ammit, A. J., Grunstein, R. R., & Phillips, C. L. (2017) · Sleep Science and Practice · doi:10.1186/s41606-017-0019-2 · Cited by 79
The circadian system, sleep, and the health/disease balance: a conceptual review
Roenneberg, T., Foster, F., & Klerman, E. B. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13621 · Cited by 81
Thompson, R. S., Gaffney, M., Hopkins, S., Kelley, T., González, A., Bowers, S. J., Vitaterna, M. H., Turek, F. W., Foxx, C. L., Lowry, C. A., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.006 · Cited by 82
Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
Liberman, A. R., Kwon, S. B., Vu, H., Filipowicz, A., Ay, A. A., & Ingram, K. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-07957-4 · Cited by 75
Sterling, P. (2020) · The MIT Press eBooks · doi:10.7551/mitpress/11472.001.0001 · Cited by 118
Machine learning identifies a compact gene set for monitoring the circadian clock in human blood
Hughey, J. (2017) · Genome Medicine · doi:10.1186/s13073-017-0406-4 · Cited by 73
“This misalignment, especially if it affects clocks in peripheral tissues besides the blood, may be relevant to the adverse metabolic and cardio-vascular effects caused by the forced-desynchrony protocol [53, 54].”
BackgroundMealtime: A circadian disruptor and determinant of energy balance?
Ruddick-Collins, L. C., Morgan, P. J., & Johnstone, A. M. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12886 · Cited by 77
Liu, C.-J., Li, Y., Hu, Y., & Zhao, B. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s277377 · Cited by 73
Gabryelska, A., Turkiewicz, S., Karuga, F. F., Sochal, M., Strzelecki, D., & Białasiewicz, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020709 · Cited by 74
Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure
Faraci, F. M., & Scheer, F. A. J. L. (2024) · Circulation Research · doi:10.1161/circresaha.124.323515 · Cited by 91
“67 This increase was primarily caused by an increase in the sleep-associated BP and caused a blunting of the BP dip.”
Self-citationMeal timing and its role in obesity and associated diseases
Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72
“Furthermore, mistimed meal intake resulted in a phase shift in the peripheral clocks of the adipose tissue (30), changes in blood pressure (85), and an increase in in fl ammatory markers (86).”
BackgroundThe impact of glucocorticoids and statins on sleep quality
Szmyd, B., Rogut, M., Białasiewicz, P., & Gabryelska, A. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101380 · Cited by 66
Phoi, Y. Y., Rogers, M., Bonham, M. P., Dorrian, J., & Coates, A. M. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000123 · Cited by 67
“This misalignment has been shown to raise glucose and insulin levels, blood pressure, and inflammatory markers in healthy adults(7,8).”
BackgroundLi, H., Kilgallen, A. B., Münzel, T. F., Wolf, E., Lecour, S., Schulz, R., Daiber, A., & Laake, L. W. V. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14949 · Cited by 67
“In another study, short-term circadian misalignment (12-hr inverted behavioural and environmental cycles for 3 days) per se increased BP and inflammatory markers (Morris et al., 2016).”
BackgroundChrononutrition—When We Eat Is of the Essence in Tackling Obesity
Ahluwalia, M. K. (2022) · Nutrients · doi:10.3390/nu14235080 · Cited by 76
Timing of food intake: Sounding the alarm about metabolic impairments? A systematic review
Beccuti, G., Monagheddu, C., Evangelista, A., Ciccone, G., Broglio, F., Soldati, L., & Bo, S. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.09.005 · Cited by 64
Khalyfa, A., Poroyko, V. A., Qiao, Z., Gileles‐Hillel, A., Khalyfa, A. A., Akbarpour, M., Almendros, I., Farré, R., & Gozal, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00882 · Cited by 66
“The most common health complaint of shift workers is lack of sleep (Lu et al., 2017b), association with cardiovascular disease (Morris et al., 2016; Lu et al., 2017a), and gastrointestinal disorders (Koh et al., 2014).”
BackgroundSűdy, Á. R., Ella, K., Bódizs, R., & Káldi, K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00950 · Cited by 65
“Both epidemiological and laboratory studies indicate that severe forms of circadian misalignment such as shift work or jetlag adversely affect the circulatory system and therefore increase the risk of the development of cardiovascular diseases (Knutsson, 2003; Grimaldi et al., 2016; Morris et al., 2016; Vetter et al.,…”
BackgroundSleep duration in preschool children and impact of screen time
Lan, Q.-Y., Chan, K. C., Yu, K. N., Chan, N. Y., Wing, Y. K., Li, A. M., & Au, C. T. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.09.024 · Cited by 63
Metadata
- Authors
- Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-02-08
- Volume
- 113
- Issue
- 10
- Pages
- E1402-11
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4790999
- OpenAlex
- W2259214365
- Cited by
- 691
- References
- 81
- Citations by year
- 2026: 82 · 2025: 84 · 2024: 69 · 2023: 87 · 2022: 82 · 2021: 74 · 2020: 64 · 2019: 49 · 2018: 43 · 2017: 45 · 2016: 10
- FWCI
- 69.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration (NCC958)
- Brigham and Women's Hospital (UL1RR025758)
- Harvard University (UL1RR025758)
- National Space Biomedical Research Institute (P01 AG009975, NCC 9‐58)
- National Institute on Aging (R01AG048108, P01AG009975)
- National Heart, Lung, and Blood Institute (R00HL102241, R01HL118601, R01HL094806)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099512, DK099512)
- National Center for Research Resources (UL1RR025758)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- circadian misalignment, shift work, cardiovascular risk, hypertension, blood pressure, sleep blood pressure, cardiac vagal modulation, heart rate variability, urinary epinephrine, urinary norepinephrine, inflammation, interleukin-6, C-reactive protein, resistin, TNF-α
- MeSH terms
- Adult, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Circadian Rhythm, Epinephrine, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Risk Factors, Time Factors, Tumor Necrosis Factor-alpha, Work Schedule Tolerance, Interleukin-6, Polysomnography, Cross-Over Studies, Sleep Disorders, Circadian Rhythm, Resistin, Young Adult, Actigraphy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
