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Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy
Open accessAbstract
Significance: In the past decade, countless studies have been performed to control the mechanical and corrosion property of magnesium-based alloy, which degrades in the physiological environment, to overcome the flaws of the inert implant materials and shift the paradigm of conventional bone fixation devices. Controlled degradation of Mg-5wt%Ca-1wt%Zn alloy results in the formation of biomimicking calcification matrix at the degrading interface to initiate the bone formation process. This process facilitates early bone healing and allows the complete replacement of biodegradable Mg implant by the new bone within 1 y of implantation, as demonstrated in 53 cases of successful long-term clinical study.
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Cited by
Biodegradable magnesium-based implants in orthopedics-a general review and perspectives
Wang, J., Xu, J., Hopkins, C., Chow, D. H., & Qin, L. (2020) · Advanced Science · doi:10.1002/advs.201902443 · Cited by 574
Current status and outlook on the clinical translation of biodegradable metals
Han, H.-S., Loffredo, S., Jun, I., Edwards, J., Kim, Y.-C., Seok, H.-K., Witte, F., Mantovani, D., & Glyn-Jones, S. (2019) · Materials Today · doi:10.1016/j.mattod.2018.05.018 · Cited by 423
Self-citationAdditive manufacturing of biodegradable metals: Current research status and future perspectives
Qin, Y., Wen, P., Guo, H., Xia, D., Zheng, Y., Jauer, L., Poprawe, R., Voshage, M., & Schleifenbaum, J. H. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.046 · Cited by 303
Qi, T., Weng, J., Yu, F., Zhang, W., Li, G., Qin, H., Tan, Z., & Zeng, H. (2021) · Biological Trace Element Research · doi:10.1007/s12011-020-02183-y · Cited by 115
Chen, L., Zhu, J., Ge, N., Liu, Y., Yan, Z., Liu, G., Li, Y., Wang, Y., Wu, G., Qiu, T., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2024.122992 · Cited by 53
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Metadata
- Authors
- Lee, J.-W., Han, H.-S., Han, K.-J., Park, J., Jeon, H., Ok, M.-R., Seok, H.-K., Ahn, J.-P., Lee, K. E., Lee, D.-H., Yang, S.-J., Cho, S.-Y., Cha, P.-R., Kwon, H., Nam, T.-H., Han, J. H. L., Rho, H.-J., Lee, K.-S., Kim, Y.-C., & Mantovani, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-01-04
- Volume
- 113
- Issue
- 3
- Pages
- 716-721
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2225772248
- Cited by
- 480
- References
- 0
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, J.-W., Han, H.-S., Han, K.-J., Park, J., Jeon, H., Ok, M.-R., Seok, H.-K., Ahn, J.-P., Lee, K. E., Lee, D.-H., Yang, S.-J., Cho, S.-Y., Cha, P.-R., Kwon, H., Nam, T.-H., Han, J. H. L., Rho, H.-J., Lee, K.-S., Kim, Y.-C., & Mantovani, D. (2016). Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1518238113
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