Insights into the role of magnesium ions in affecting osteogenic differentiation of mesenchymal stem cells
Abstract
Bone marrow mesenchymal stem cells (MSCs) are multipotent stem cells with the ability to differentiate into bone-producing cells, which is essential for bone formation. Magnesium biomedical materials, such as biodegradable matters with osteoinductive properties, play a vital role in the osteogenic differentiation of MSCs. International and Chinese studies have shown that magnesium ions, which are produced by biodegradation, mainly achieve this effect by regulating the expression of genes and proteins associated with osteogenesis, activating multiple signal pathways, elevating autophagic activities, and adjusting the pH in the microenvironment. It is of great significance to study the regulatory mechanisms and identify the optimal conditions that how magnesium ions promote osteogenic differentiation of MSCs. In this study, we summarized the regulatory mechanisms noted above.
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Mg2+ formed by biodegradation promote osteogenic differentiation of MSCs by elevating autophagic activities.
“Studies have reported that Mg2+, which are formed by biodegradation, promote the osteogenic differentiation of MSCs by elevating autophagic activities [24].”
Cites
Magnesium and its alloys as orthopedic biomaterials: A review
Staiger, M. P., Pietak, A. M., Huadmai, J., & Dias, G. J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.10.003 · Cited by 4,460 · see citing works
In vivo corrosion of four magnesium alloys and the associated bone response
Witte, F., Kaese, V., Haferkamp, H., Switzer, E., Meyer‐Lindenberg, A., Wirth, C. J., & Windhagen, H. J. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.049 · Cited by 2,403 · see citing works
Magnesium in man: implications for health and disease
de Baaij, J. H. F., Hoenderop, J. G. J., & Bindels, R. J. M. (2015) · Physiological Reviews · doi:10.1152/physrev.00012.2014 · Cited by 1,726 · see citing works
Control of biodegradation of biocompatable magnesium alloys
Song, G. (2007) · Corrosion Science · doi:10.1016/j.corsci.2007.01.001 · Cited by 1,519 · see citing works
In vitro and in vivo corrosion measurements of magnesium alloys
Witte, F., Fischer, J., Nellesen, J., Crostack, H. ‐., Kaese, V., Pisch, A., Beckmann, F., & Windhagen, H. J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.07.037 · Cited by 1,389 · see citing works
Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
Vizoso, F., Eiro, N., Cid, S., Schneider, J., & Perez-Fernandez, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091852 · Cited by 1,363 · see citing works
Gnecchi, M., He, H., Noiseux, N., Liang, O. D., Zhang, L., Morello, F., Mu, H., Melo, L. G., Pratt, R. E., Ingwall, J. S., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5211com · Cited by 1,158 · see citing works
Atashi, F., Modarressi, A., & Pepper, M. S. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0484 · Cited by 655 · see citing works
Yoshizawa, S., Brown, A., Barchowsky, A., & Sfeir, C. S. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.02.002 · Cited by 578 · see citing works
Sicco, C. L., Reverberi, D., Balbi, C., Ulivi, V., Principi, E., Pascucci, L., Becherini, P., Bosco, M. C., Varesio, L., Franzin, C., et al. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0363 · Cited by 560 · see citing works
Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration
Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., Akimoto, T., Higashi, Y., & Ochi, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.03.031 · Cited by 511 · see citing works
Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy
Lee, J.-W., Han, H., Han, K., Park, J., Jeon, H., Ok, M., Seok, H., Ahn, J., Lee, K. E., Lee, D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518238113 · Cited by 480 · see citing works
Key transcription factors in the differentiation of mesenchymal stem cells
Almalki, S. G., & Agrawal, D. K. (2016) · Differentiation · doi:10.1016/j.diff.2016.02.005 · Cited by 422 · see citing works
Utech, S., & Boccaccini, A. R. (2015) · Journal of Materials Science · doi:10.1007/s10853-015-9382-5 · Cited by 362 · see citing works
Robinson, D. A., Griffith, R. W., Shechtman, D., Evans, R. B., & Conzemius, M. G. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.10.007 · Cited by 351 · see citing works
Cui, Y., Luan, J., Li, H., Zhou, X., & Han, J. (2016) · FEBS Letters · doi:10.1002/1873-3468.12024 · Cited by 292 · see citing works
Biodegradable Magnesium Alloys: A Review of Material Development and Applications
Persaud-Sharma, D., & McGoron, A. J. (2012) · Journal of Biomimetics Biomaterials and Tissue Engineering · doi:10.4028/www.scientific.net/jbbte.12.25 · Cited by 287 · see citing works
Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts.
Hallab, N., Vermes, C., Messina, C., Roebuck, K., Glant, T., & Jacobs, J. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10106 · Cited by 282 · see citing works
Koh, Y. G., Kwon, O., Kim, Y., Choi, Y., & Tak, D.-H. (2015) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2015.09.010 · Cited by 259 · see citing works
de Windt, T. S., Vonk, L. A., Slaper‐Cortenbach, I., van den Broek, M. P. H., Nizak, R., van Rijen, M. H. P., de Weger, R. A., Dhert, W. J. A., & Saris, D. B. F. (2016) · Stem Cells · doi:10.1002/stem.2475 · Cited by 242 · see citing works
Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer
Peng, W., Huang, J., Yang, L., Gong, A., & Mo, Y. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0727-3 · Cited by 237 · see citing works
Zhang, J., Ma, X., Lin, D., Shi, H., Yuan, Y., Tang, W. D., Zhou, H., Guo, H., Qian, J., & Liu, C. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.097 · Cited by 233 · see citing works
Zhang, X., Zu, H., Zhao, D., et al. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.08.051 · Cited by 183 · see citing works
Díaz‐Tocados, J. M., Herencia, C., Martinez-Moreno, J. M., de Oca, A. M., Rodríguez-Ortiz, M. E., Vergara, N., Blanco, A., Steppan, S., Almadén, Y., Rodríguez, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08379-y · Cited by 176 · see citing works
Wang, X., Omar, O., Vazirisani, F., Thomsen, P., & Ekström, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193059 · Cited by 176 · see citing works
de Oca, A. M., Guerrero, F., Martinez-Moreno, J. M., Madueño, J. A., Herencia, C., Peralta-Ramírez, A., Almadén, Y., Lopez, I., Aguilera‐Tejero, E., Gundlach, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089525 · Cited by 168 · see citing works
Gu, Y., Zhang, J., Zhang, X., Liang, G., Xu, T., & Niu, W. (2019) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-019-00192-0 · Cited by 168 · see citing works
Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials
Jeon, O. H., Panicker, L. M., Lu, Q., Chae, J. J., Feldman, R. A., & Elisseeff, J. H. (2016) · Scientific Reports · doi:10.1038/srep26761 · Cited by 152 · see citing works
High magnesium inhibits human osteoblast differentiation in vitro
Leidi, M., Dellera, F., Mariotti, M., & Maier, J. A. M. (2011) · Magnesium Research · doi:10.1684/mrh.2011.0271 · Cited by 148 · see citing works
Dual Function of Magnesium in Bone Biomineralization
Zhang, J., Tang, L., Qi, H., Zhao, Q. P., Liu, Y., & Zhang, Y. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201901030 · Cited by 148 · see citing works
Wang, J., Ma, X.-Y., Feng, Y., Ma, Z.-S., Ma, T., Zhang, Y., Li, X., Wang, L. Q., & Lei, W. (2017) · Biological Trace Element Research · doi:10.1007/s12011-017-0948-8 · Cited by 129 · see citing works
Monfoulet, L., Becquart, P., Marchat, D., et al. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0500 · Cited by 120 · see citing works
Chiang, E., Ma, H., Wang, J., Liu, C., Chen, T.-H., & Hung, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149835 · Cited by 115 · see citing works
Shimaya, M., Muneta, T., Ichinose, S., Tsuji, K., & Sekiya, I. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.06.005 · Cited by 106 · see citing works
Inhibition of Osteoclastogenesis by Mechanically Loaded Osteocytes: Involvement of MEPE
Kulkarni, R. N., Bakker, A. D., Everts, V. E., & Klein‐Nulend, J. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9407-7 · Cited by 103 · see citing works
A New Source of Mesenchymal Stem Cells for Articular Cartilage Repair
Fu, W., Zhou, C.-Y., & Yu, J. (2013) · The American Journal of Sports Medicine · doi:10.1177/0363546513512778 · Cited by 101 · see citing works
Yu, W., Zhao, H., Ding, Z., et al. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.10.037 · Cited by 101 · see citing works
Wang, J., Xu, J., Song, B., Chow, D. H. K., Yung, P. S., & Qin, L. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.09.018 · Cited by 96 · see citing works
Yang, C., Yuan, G., Zhang, J., Tang, Z., Zhang, X., & Dai, K. (2010) · Biomedical Materials · doi:10.1088/1748-6041/5/4/045005 · Cited by 92 · see citing works
Emerging Insights into Wnt/β-catenin Signaling in Head and Neck Cancer
Abalkhail, K. A., & Kukuruzinska, M. A. (2018) · Journal of Dental Research · doi:10.1177/0022034518771923 · Cited by 90 · see citing works
Versatile effects of magnesium hydroxide nanoparticles in PLGA scaffold–mediated chondrogenesis
Park, K., Kim, B., Lih, E., Park, W., Lee, S., Joung, Y. K., & Han, D. K. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.022 · Cited by 88 · see citing works
Wu, D., Liang, M., Dang, H., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.193 · Cited by 82 · see citing works
Cipriano, A. F., Sallee, A., Guan, R., et al. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.10.018 · Cited by 81 · see citing works
Wang, W., Jia, G., Wang, Q., Huang, H., Li, X., Zeng, H., Ding, W., Witte, F., Zhang, C., Jia, W., et al. (2020) · Materials & Design · doi:10.1016/j.matdes.2020.108514 · Cited by 81 · see citing works
Self-citationEffects of magnesium degradation products on mesenchymal stem cell fate and osteoblastogenesis
Luthringer-Feyerabend, B., & Willumeit‐Römer, R. (2015) · Gene · doi:10.1016/j.gene.2015.08.028 · Cited by 80 · see citing works
Li, R., Kirkland, N. T., Truong, J., et al. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35111 · Cited by 80 · see citing works
Kim, J. A., Yun, H., Choi, Y., Kim, J., Choi, S., Kwon, T., Kim, Y. K., Kwon, T., Bae, M. A., Kim, N. J., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.032 · Cited by 80 · see citing works
Johnson, I., Perchy, D., & Liu, H. H. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33290 · Cited by 78 · see citing works
Zinc Inhibits H2O2-Induced MC3T3-E1 Cells Apoptosis via MAPK and PI3K/AKT Pathways
Liang, D., Yang, M., Guo, B., Cao, J., Yang, L., Guo, X., Li, Y., & Gao, Z. (2012) · Biological Trace Element Research · doi:10.1007/s12011-012-9387-8 · Cited by 74 · see citing works
Kim, B., Kim, J. S., Park, Y. M., et al. (2012) · Materials Science and Engineering C · doi:10.1016/j.msec.2012.12.061 · Cited by 73 · see citing works
Omentin-1 Stimulates Human Osteoblast Proliferation through PI3K/Akt Signal Pathway
Wu, S., Liang, Q.-H., Liu, Y., Cui, R., Yuan, L., & Liao, E.-Y. (2013) · International Journal of Endocrinology · doi:10.1155/2013/368970 · Cited by 73 · see citing works
Jia, G., Hou, Y., Chen, C., Niu, J., Zhang, H., Huang, H., Xiong, M., & Yuan, G. (2017) · Materials & Design · doi:10.1016/j.matdes.2017.11.064 · Cited by 70 · see citing works
Zhang, L., Yang, C., Li, J., Zhu, Y., & Zhang, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.07.004 · Cited by 66 · see citing works
In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor
Zhao, D., Wang, T., Kuhlmann, J., et al. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.03.039 · Cited by 65 · see citing works
Galli, S., Stocchero, M., Andersson, M., Karlsson, J. E., He, W., Lilin, T., Wennerberg, A., & Jimbo, R. (2017) · Osteoporosis International · doi:10.1007/s00198-017-4004-5 · Cited by 63 · see citing works
Jia, G., Chen, C., Zhang, J., Wang, Y., Yue, R., Luthringer-Feyerabend, B., Willumeit‐Römer, R., Zhang, H., Xiong, M., Huang, H., et al. (2018) · Corrosion Science · doi:10.1016/j.corsci.2018.09.001 · Cited by 62 · see citing works
Rangaswami, H., Schwappacher, R., Tran, T. P., Chan, G., Zhuang, S., Boss, G. R., & Pilz, R. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.347245 · Cited by 61 · see citing works
Fliefel, R. M., Popov, C., Troeltzsch, M., Kühnisch, J., Ehrenfeld, M., & Otto, S. (2016) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2016.03.003 · Cited by 60 · see citing works
Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication
Niu, J., Yan, T., Guo, W., Wang, W., & Zhao, Z. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01232 · Cited by 56 · see citing works
Hussain, A., Bessho, K., Takahashi, K., et al. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0310 · Cited by 48 · see citing works
Li, Y., Wang, J., Yue, J., Wang, Y., Yang, C., & Cui, Q. (2017) · Cell Biology International · doi:10.1002/cbin.10888 · Cited by 46 · see citing works
Zhao, D., Brown, A., Wang, T., Yoshizawa, S., Sfeir, C. S., & Heineman, W. R. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.032 · Cited by 43 · see citing works
Battle in the New World: Helicoverpa armigera versus Helicoverpa zea (Lepidoptera: Noctuidae)
Bentivenha, J. P. F., de Paula-Moraes, S. V., Baldin, E. L. L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167182 · Cited by 42 · see citing works
Magnesium Silicate Bioceramics for Bone Regeneration: A Review
Devi, K. B., Nandi, S. K., & Roy, M. (2019) · Journal of the Indian Institute of Science · doi:10.1007/s41745-019-00119-7 · Cited by 41 · see citing works
Wu, C., Chen, P., Li, T., Fong, Y., & Tang, C. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-277 · Cited by 39 · see citing works
Reconstruction of radial bone defect in rat by calcium silicate biomaterials
Oryan, A., & Alidadi, S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.03.048 · Cited by 39 · see citing works
Dai, Y., Tang, Y., Xu, X., Luo, Z., Zhang, Y., Li, Z., Lin, Z., Zhao, S., Zeng, M., Sun, B., et al. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34344 · Cited by 30 · see citing works
TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro
Castiglioni, S., Romeo, V., Locatelli, L., Cazzaniga, A., & Maier, J. A. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-34324-8 · Cited by 28 · see citing works
Kang, Y. G., Wei, J., Shin, J. W., et al. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s157921 · Cited by 27 · see citing works
The effect of Mg–Ca–Sr alloy degradation products on human mesenchymal stem cells
Berglund, I. S., Dirr, E. W., Ramaswamy, V., et al. (2017) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33869 · Cited by 25 · see citing works
Hydrogen inhibits the osteoclastogenesis of mouse bone marrow mononuclear cells
Liu, Y., Wang, D., Huang, Y., Wang, T., & Zeng, H. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110640 · Cited by 22 · see citing works
Self-citationEffects of fluctuant magnesium concentration on phenotype of the primary chondrocytes
Dou, Y., Li, N., Zheng, Y., et al. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35113 · Cited by 21 · see citing works
Kim, J., & Gilbert, J. L. (2018) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34109 · Cited by 19 · see citing works
Önder, S., Koyuncu, A. C. Ç., Kazmanlı, K., et al. (2018) · Bio-Medical Materials and Engineering · doi:10.3233/bme-181000 · Cited by 19 · see citing works
Won, S., Huh, Y., Cho, L., et al. (2017) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-017-0028-3 · Cited by 18 · see citing works
Kang, Y. G., Wei, J., Kim, J. E., Wu, Y. R., Lee, E. J., Su, J., & Shin, J. (2018) · RSC Advances · doi:10.1039/c8ra06281a · Cited by 15 · see citing works
Wang, S., Li, S., Hu, M., & Huo, B. (2019) · Biomicrofluidics · doi:10.1063/1.5128696 · Cited by 15 · see citing works
Advances in Metallic Biomaterials with both Osteogenic and Anti-Infection Properties
Lin, X. Y., Ge, J. C., Wu, S., et al. (2017) · Acta Metallurgica Sinica · doi:10.11900/0412.1961.2017.000269 · Cited by 3 · see citing works
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- Authors
- Qi, T., Weng, J., Yu, F., Zhang, W., Li, G., Qin, H., Tan, Z., & Zeng, H.
- Affiliations
- Peking University Shenzhen Hospital (CN)
- Corresponding author
- Zeng, Hui
- Venue
- Biological Trace Element Research
- Published
- 2020-05-24
- Volume
- 199
- Issue
- 2
- Pages
- 559-567
- ISSN
- 0163-4984 (ISSN-L)
- 1559-0720
- OpenAlex
- W3028418725
- Cited by
- 115
- References
- 78
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 16 · 2023: 23 · 2022: 14 · 2021: 14 · 2020: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Trace Element Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- 'San-ming' Project of Medicine in Shenzhen (No. SZSM201612092)
- Research and Development Projects of Shenzhen (No. JCYJ20170307111755218)
- basic research project of Peking University Shenzhen hospital (NO.JCYJ2018004)
- Natural Science Foundation of Guangdong Province, China (2019A1515011290)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Keywords
- magnesium ions, osteogenic differentiation, mesenchymal stem cells, bone marrow-derived stem cells, osteoinduction, biodegradation, autophagy, signaling pathways, gene expression regulation
- MeSH terms
- Cell Differentiation, Cells, Cultured, Ions, Magnesium, Osteogenesis, Mesenchymal Stem Cells
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