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Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia
Open accessAbstract
The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid . This finding identifies a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.
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Cited by
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TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2and 12-Lipoxygenase
Shim, W.-S., Tak, M.-H., Lee, M.-H., Kim, M., Kim, M., Koo, J.-Y., Lee, C.-H., Kim, M., & Oh, U. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4643-06.2007 · Cited by 465
Self-citationTRPV1 Channels Mediate Long-Term Depression at Synapses on Hippocampal Interneurons
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Meyer, R. A., Ringkamp, M., Campbell, J. N., & Raja, S. N. (2006) · Wall and Melzack's Textbook of Pain · doi:10.1016/b0-443-07287-6/50006-0 · Cited by 317
Metadata
- Authors
- Shin, J., Cho, H., Hwang, S. W., Jung, J., Shin, C. Y., Lee, S.-Y., Kim, S. H., Lee, M. G., Choi, Y. H., Kim, J., Haber, N. A., Reichling, D. B., Khasar, S., Levine, J. D., & Oh, U.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-07-03
- Volume
- 99
- Issue
- 15
- Pages
- 10150-10155
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059398421
- Cited by
- 355
- References
- 0
- FWCI
- 16.17
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. https://app.cochat.ai/papers/10.1073/pnas.152002699
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- Shin, J., Cho, H., Hwang, S. W., Jung, J., Shin, C. Y., Lee, S.-Y., Kim, S. H., Lee, M. G., Choi, Y. H., Kim, J., Haber, N. A., Reichling, D. B., Khasar, S., Levine, J. D., & Oh, U. (2002). Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.152002699
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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