The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2and 12-Lipoxygenase
Open accessAbstract
Histamine provokes itching and is a major skin disease complaint. Histamine is known to excite a subset of sensory neurons, predominantly C-fibers. Although histamine is pruritogenic, its signaling pathways that excite sensory neurons have not been identified. Because the metabolic products of lipoxygenases (LOs) activate transient receptor potential vanilloid receptor-1 (TRPV1) in sensory neurons, we hypothesized that histamine excites sensory neurons by activating TRPV1 via phospholipase A 2(PLA 2) and LO stimulation. In cultured sensory neurons, histamine evoked inward currents that were reduced by capsazepine, a TRPV1 blocker. Moreover, histamine provoked inward currents when histamine receptor subtype 1 (H1R) and TRPV1 were expressed heterologously, but not when H1R or TRPV1 was expressed alone. In addition, histamine caused Ca 2+influxes in sensory neurons in wild-type mice but not in TRPV1−/−mice. Furthermore, histamine caused a 2.5-fold increase in the production of 12-hydroxyeicosatetraenoic acid, a metabolite of LO, in cultured sensory neurons. When injected subcutaneously into the necks of mice, histamine caused bouts of scratching, which were greatly reduced by pretreatment with capsazepine, a TRPV1 blocker, and by inhibitors of PLA 2, LO, and H1R. Furthermore, mice lacking TRPV1 markedly reduced histamine-induced scratching compared with wild type. Together, these results indicate that TRPV1 plays a key role in mediating the pruritogenic action of histamine via the PLA 2/LO pathway.
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Cited by
The Cells and Circuitry for Itch Responses in Mice
Mishra, S. K., & Hoon, M. A. (2013) · Science · doi:10.1126/science.1233765 · Cited by 507
Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Mollanazar, N. K., Smith, P. K., & Yosipovitch, G. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8488-5 · Cited by 353
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Peripheral itch sensitization in atopic dermatitis
Tominaga, M., & Takamori, K. (2022) · Allergology International · doi:10.1016/j.alit.2022.04.003 · Cited by 160
Itch: Pathogenesis and treatment
Sutaria, N., Adawi, W., Goldberg, R., Roh, Y. S., Choi, J., & Kwatra, S. G. (2022) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2021.07.078 · Cited by 130
Metadata
- Authors
- Shim, W.-S., Tak, M.-H., Lee, M.-H., Kim, M., Kim, M., Koo, J.-Y., Lee, C.-H., Kim, M., & Oh, U.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-02-28
- Volume
- 27
- Issue
- 9
- Pages
- 2331-2337
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1997380538
- Cited by
- 465
- References
- 44
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shim, W.-S., Tak, M.-H., Lee, M.-H., Kim, M., Kim, M., Koo, J.-Y., Lee, C.-H., Kim, M., & Oh, U. (2007). TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2and 12-Lipoxygenase. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.4643-06.2007
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