The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins
Abstract
Significance: This report describes an important new mechanism regulating protein degradation in mammalian cells through phosphorylation of the 26S proteasome. Treatments that raise cAMP and activate PKA cause phosphorylation of Rpn6/PSMD11, a subunit of the 19S regulatory complex. This modification enhances the proteasome’s capacity to hydrolyze ubiquitinated proteins, ATP, and small peptides, and in cells stimulates the degradation of aggregation-prone proteins, including ones that cause neurodegenerative diseases (tau, SOD1, TDP43, and FUS). Our related collaborative study demonstrated that raising cAMP in brain promotes the clearance of aggregated tau in a mouse tauopathy model. This enhancement of proteasome activity and breakdown of misfolded proteins represents a new function of the cAMP/PKA pathway that offers a promising approach to treat proteotoxic diseases.
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“UPS (re)activation delays Tau aggregation and neurodegeneration in vitro and in vivo (Han et al., 2014, Lokireddy et al., 2015, Myeku et al., 2016).”
From Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons (2019) · cites this paper as Lokireddy et al., 2015
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Cites
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Cited by
Sorted by citations
Roles of tau protein in health and disease
Guo, T., Noble, W., & Hanger, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1707-9 · Cited by 1,003
Mitochondrial metabolism promotes adaptation to proteotoxic stress
Tsvetkov, P., Detappe, A., Cai, K., Keys, H. R., Brune, Z., Ying, W., Thiru, P., Reidy, M., Kugener, G., Rossen, J., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0291-9 · Cited by 645
Regulation of proteasome assembly and activity in health and disease
Rousseau, A., & Bertolotti, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0040-z · Cited by 510
Myeku, N., Clelland, C. L., Emrani, S., Kukushkin, N. V., Yu, W. H., Goldberg, A. L., & Duff, K. E. (2016) · Nature Medicine · doi:10.1038/nm.4011 · Cited by 446
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Metadata
- Authors
- Lokireddy, S., Kukushkin, N. V., & Goldberg, A. L.
- Affiliations
- Department of Cell Biology, Harvard Medical School, Boston, MA 02115
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-12-15
- Volume
- 112
- Issue
- 52
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 228
- References
- 7
- Language
- en
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