The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling
Abstract
Significance: The directed differentiation of human embryonic stem cells into cardiomyocytes provides a tool for understanding human heart development and disease. During the process of cardiomyocyte differentiation, tight regulation of the WNT/β-catenin signaling pathway is required. Thus, understanding which proteins are involved in promoting or repressing the WNT/β-catenin signaling pathway is crucial for identifying positive and negative regulators of cardiac development. Here we measured protein expression during a time course of cardiomyocyte differentiation. We identified a regulator of cardiac development, Disabled 2, and found that in zebrafish embryos, it negatively regulates WNT/β-catenin signaling to promote cardiomyocyte differentiation. Thus, our work reveals a highly conserved, previously unidentified process relevant for human heart development.
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Deletion of Dab2 in zebrafish embryos through Cas9 mutagenesis resulted in a significant reduction in cardiomyocyte number.
“Deletion of Dab2 in zebrafish embryos through Cas9 mutagenesis resulted in a significant reduction in cardiomyocyte number (Hofsteen et al., 2016)”
From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Hofsteen et al., 2016
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Research works printed but not linked: 30
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Cited by
Sorted by citations
Bargehr, J., Ong, L. P., Colzani, M., Davaapil, H., Hofsteen, P., Bhandari, S., Gambardella, L., Le Novère, N., Iyer, D., Sampaziotis, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0197-9 · Cited by 195
Self-citationEndocytosis and Physiology: Insights from Disabled-2 Deficient Mice
Tao, W., Moore, R., Smith, E. R., & Xu, X.-X. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00129 · Cited by 43
Metadata
- Authors
- Hofsteen, P., Robitaille, A. M., Chapman, D. P., Moon, R. T., & Murry, C. E.
- Affiliations
- Department of Pathology, University of Washington, Seattle, WA 98109;
- Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-01-11
- Volume
- 113
- Issue
- 4
- Pages
- 1002-1007
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 50
- References
- 4
- Language
- en
- Funders
- HHS | NIH | National Heart, Lung, and Blood Institute (NIH T32 HL007312, U01 HL100405, R01 HL084642, P01 HL094374)
- HHS | NIH | National Institute of General Medical Sciences (P01 GM081619)
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