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Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport

Morris, Shelli M., Tallquist, Michelle D., Rock, Charles O., Cooper, Jonathan A.·2002·The EMBO Journal
DOI 10.1093/emboj/21.7.1555
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  • The impact of Dab2 deletion on cardiac development is not notable.

    “though impact of Dab2 deletion on cardiac development is not notable (Morris et al., 2002b; Moore et al., 2013).”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Morris et al., 2002b

    The rescue section (page unavailable) reports that mice with Dab2 deleted from the embryo proper appeared normal, were born and survived, supporting no obvious developmental defect under that condition. It does not assess cardiac development specifically; complete Dab2 deletion instead caused early embryonic lethality, as reported in the targeting section (page unavailable). (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Dab2 is linked to megalin endocytosis in the kidney in vivo.

    “This links Dab2 to megalin endocytosis in the kidney in vivo.”

    From Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor (2002) · cites this paper as Morris et al., 2002b

  • No increased tumor incidence was reported in the characterization of a Dab2 conditional knockout line using Meox2-Cre.

    “though no increased tumor incidence was reported in the characterization of a Dab2 conditional knockout line (using Meox2-Cre; Morris et al., 2002b).”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Morris et al., 2002b

  • Conventional dab2 gene deletion in mice results in early embryonic death.

    “Conventional dab2 gene deletion in mice results in early embryonic death”

    From Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol (2016) · cites this paper as [27]

  • The phenotype of Dab2 nullizygous mice supports a role for Dab2 in endocytosis.

    “The phenotype of Dab2 nullizygous mice also supports a role for Dab2 in endocytosis.”

    From Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor (2002) · cites this paper as Morris et al., 2002b

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Metadata

Authors
Morris, S. M., Tallquist, M. D., Rock, C. O., & Cooper, J. A.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2002-04-01
Volume
21
Issue
7
Pages
1555-1564
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1093/emboj/21.7.1555
Cited by
186
References
0
Language
en
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