The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Design of a small molecule against an oncogenic noncoding RNA
Open accessAbstract
Significance: The goal of precision medicine is to identify selective drugs that modulate disease-causing biomolecules. This slow process often involves developing a high-throughput screen to test millions of potential drugs to find a few that affect the biomolecule. Here, we describe a facile approach using a disease-causing biomolecule’s sequence to enable design of specific drugs, eliminating arduous and time-consuming screens. By using the sequence of a non–protein-coding, oncogenic RNA, we designed a drug specifically targeting the RNA’s folded structure. In cells and animals, the drug inhibits its target, killing cancer cells while leaving healthy cells unaffected. Thus, a preclinical anticancer drug candidate can be quickly designed from sequence.
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Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922
In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features
Ding, Y., Tang, Y., Kwok, C. K., Zhang, Y., Bevilacqua, P. C., & Assmann, S. M. (2014) · Nature · doi:10.1038/nature12756 · Cited by 775
Progress in antisense technology
Crooke, S. T. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.104408 · Cited by 417
Cited by
Noncoding RNA therapeutics—Challenges and potential solutions
Winkle, M., El-Daly, S. M., Fabbri, M., & Calin, G. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00219-z · Cited by 1,551
Yan, H., & Bu, P. (2021) · Essays in Biochemistry · doi:10.1042/ebc20200032 · Cited by 667
Targeting RNA structures with small molecules
Childs-Disney, J. L., Yang, X., Gibaut, Q. M. R., Tong, Y., Batey, R. T., & Disney, M. D. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00521-4 · Cited by 587
Self-citationLong Noncoding RNA in Cancer: Wiring Signaling Circuitry
Lin, C., & Yang, L. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.11.008 · Cited by 488
Small Molecule Targeted Recruitment of a Nuclease to RNA
Costales, M. G., Matsumoto, Y., Velagapudi, S. P., & Disney, M. D. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b01233 · Cited by 212
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Metadata
- Authors
- Velagapudi, S. P., Cameron, M. D., Haga, C. L., Rosenberg, L. H., Lafitte, M., Duckett, D. R., Phinney, D. G., & Disney, M. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-05-11
- Volume
- 113
- Issue
- 21
- Pages
- 5898-5903
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2383467331
- Cited by
- 218
- References
- 4
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Velagapudi, S. P., Cameron, M. D., Haga, C. L., Rosenberg, L. H., Lafitte, M., Duckett, D. R., Phinney, D. G., & Disney, M. D. (2016). Design of a small molecule against an oncogenic noncoding RNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1523975113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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